Comparison of azithromycin and metronidazole in a quadruple-therapy regimen for <i>Helicobacter pylori</i> eradication in dyspepsia
<b>Background/Aim: </b><i>Helicobacter pylori</i> (<i>H pylori</i>)<b> </b> plays an important role in the pathogenesis of chronic gastritis, peptic ulcer disease, and gastric neoplasms<b> . </b> Therefore, it is necessary to<b> <...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2009-01-01
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| Series: | The Saudi Journal of Gastroenterology |
| Subjects: | |
| Online Access: | http://www.saudijgastro.com/article.asp?issn=1319-3767;year=2009;volume=15;issue=4;spage=225;epage=228;aulast=Agah |
| _version_ | 1811195477877587968 |
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| author | Agah Shahram Shazad Babak Abbaszadeh Babak |
| author_facet | Agah Shahram Shazad Babak Abbaszadeh Babak |
| author_sort | Agah Shahram |
| collection | DOAJ |
| description | <b>Background/Aim: </b><i>Helicobacter pylori</i> (<i>H pylori</i>)<b> </b> plays an important role in the pathogenesis of chronic gastritis, peptic ulcer disease, and gastric neoplasms<b> . </b> Therefore, it is necessary to<b> </b> select an effective regimen for <i>H pylori</i> eradication<b> . </b> The aim of this study was to<b> </b> compare the efficacy of two quadruple-therapy regimens-one with<b> </b> azithromycin and the other with metronidazole-for <i>H pylori</i> eradication in patients with dyspepsia.<b> Materials and Methods: </b> In this double-blind randomized clinical trial conducted in Rasoule-Akram Hospital in 2006, we included 60 patients (aged 15-70 years) who had dyspepsia and <i>H pylori</i> infection as diagnosed by upper gastrointestinal endoscopy and rapid urease test. Patients were randomly assigned to receive a quadruple-therapy regimen for 2 weeks: 1) the MAO-B group (<i>n </i>= 30) received metronidazole 500 mg b.i.d, amoxicillin 1g b.i.d, omeprazole 20 mg b.i.d, and bismuth 240 mg b.i.d and 2) the AAO-B group (<i>n</i> = 30) received azithromycin 500 mg once daily for 1 week and amoxicillin 1g b.i.d, omeprazole 20 mg b.i.d, and bismuth 240 mg b.i.d for 2 weeks). <i>H pylori</i> eradication was assessed by the rapid urease test (RUT) 2 months after the cessation of treatment<b> . Results: </b><i>H pylori</i> was eradicated in 68% and 69% of patients in the MAO-B and AAO-B groups, respectively. There was no significant difference in <i>H pylori</i> eradication rates between the two groups (<i>P</i> = 0.939).<b> Conclusion: </b> No significant difference exists between the two quadruple-therapy regimens that were tested. |
| first_indexed | 2024-04-12T00:43:55Z |
| format | Article |
| id | doaj.art-a4c6cc58345b41828270ce4cc5154c7b |
| institution | Directory Open Access Journal |
| issn | 1319-3767 1998-4049 |
| language | English |
| last_indexed | 2024-04-12T00:43:55Z |
| publishDate | 2009-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | The Saudi Journal of Gastroenterology |
| spelling | doaj.art-a4c6cc58345b41828270ce4cc5154c7b2022-12-22T03:54:55ZengWolters Kluwer Medknow PublicationsThe Saudi Journal of Gastroenterology1319-37671998-40492009-01-01154225228Comparison of azithromycin and metronidazole in a quadruple-therapy regimen for <i>Helicobacter pylori</i> eradication in dyspepsiaAgah ShahramShazad BabakAbbaszadeh Babak<b>Background/Aim: </b><i>Helicobacter pylori</i> (<i>H pylori</i>)<b> </b> plays an important role in the pathogenesis of chronic gastritis, peptic ulcer disease, and gastric neoplasms<b> . </b> Therefore, it is necessary to<b> </b> select an effective regimen for <i>H pylori</i> eradication<b> . </b> The aim of this study was to<b> </b> compare the efficacy of two quadruple-therapy regimens-one with<b> </b> azithromycin and the other with metronidazole-for <i>H pylori</i> eradication in patients with dyspepsia.<b> Materials and Methods: </b> In this double-blind randomized clinical trial conducted in Rasoule-Akram Hospital in 2006, we included 60 patients (aged 15-70 years) who had dyspepsia and <i>H pylori</i> infection as diagnosed by upper gastrointestinal endoscopy and rapid urease test. Patients were randomly assigned to receive a quadruple-therapy regimen for 2 weeks: 1) the MAO-B group (<i>n </i>= 30) received metronidazole 500 mg b.i.d, amoxicillin 1g b.i.d, omeprazole 20 mg b.i.d, and bismuth 240 mg b.i.d and 2) the AAO-B group (<i>n</i> = 30) received azithromycin 500 mg once daily for 1 week and amoxicillin 1g b.i.d, omeprazole 20 mg b.i.d, and bismuth 240 mg b.i.d for 2 weeks). <i>H pylori</i> eradication was assessed by the rapid urease test (RUT) 2 months after the cessation of treatment<b> . Results: </b><i>H pylori</i> was eradicated in 68% and 69% of patients in the MAO-B and AAO-B groups, respectively. There was no significant difference in <i>H pylori</i> eradication rates between the two groups (<i>P</i> = 0.939).<b> Conclusion: </b> No significant difference exists between the two quadruple-therapy regimens that were tested.http://www.saudijgastro.com/article.asp?issn=1319-3767;year=2009;volume=15;issue=4;spage=225;epage=228;aulast=AgahAzithromycin<b> </b><i>Helicobacter pylori</i><b> </b> metronidazole<b> </b> quadruple-therapy regimens |
| spellingShingle | Agah Shahram Shazad Babak Abbaszadeh Babak Comparison of azithromycin and metronidazole in a quadruple-therapy regimen for <i>Helicobacter pylori</i> eradication in dyspepsia The Saudi Journal of Gastroenterology Azithromycin <b> </b><i>Helicobacter pylori</i> <b> </b> metronidazole <b> </b> quadruple-therapy regimens |
| title | Comparison of azithromycin and metronidazole in a quadruple-therapy regimen for <i>Helicobacter pylori</i> eradication in dyspepsia |
| title_full | Comparison of azithromycin and metronidazole in a quadruple-therapy regimen for <i>Helicobacter pylori</i> eradication in dyspepsia |
| title_fullStr | Comparison of azithromycin and metronidazole in a quadruple-therapy regimen for <i>Helicobacter pylori</i> eradication in dyspepsia |
| title_full_unstemmed | Comparison of azithromycin and metronidazole in a quadruple-therapy regimen for <i>Helicobacter pylori</i> eradication in dyspepsia |
| title_short | Comparison of azithromycin and metronidazole in a quadruple-therapy regimen for <i>Helicobacter pylori</i> eradication in dyspepsia |
| title_sort | comparison of azithromycin and metronidazole in a quadruple therapy regimen for i helicobacter pylori i eradication in dyspepsia |
| topic | Azithromycin <b> </b><i>Helicobacter pylori</i> <b> </b> metronidazole <b> </b> quadruple-therapy regimens |
| url | http://www.saudijgastro.com/article.asp?issn=1319-3767;year=2009;volume=15;issue=4;spage=225;epage=228;aulast=Agah |
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