PYK2 mediates the BRAF inhibitor (vermurafenib)-induced invadopodia formation and metastasis in melanomas

PYK2 mediates the BRAF inhibitor (vermurafenib)-induced invadopodia formation and metastasis in melanomas

Objective: The BRAF inhibitor, vemurafenib, has been widely used in the treatment of patients with melanoma-bearing BRAFV600E mutations. While the initial response to vemurafenib is usually excellent, the majority of patients eventually develop resistance and metastatic disease. However, the underly...

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Bibliographic Details
Main Authors: Junling Shen, Jilong Yang, Lei Sang, Rui Sun, Weiyu Bai, Chao Wang, Yan Sun, Jianwei Sun
Format: Article
Language:English
Published: China Anti-Cancer Association 2022-08-01
Series:Cancer Biology & Medicine
Subjects:
stim1
pyk2
invadopodia
invasion
melanoma
vemurafenib
Online Access:https://www.cancerbiomed.org/content/19/8/1211

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