Different associations of white matter lesions with depression and cognition
<p>Abstract</p> <p>Background</p> <p>To test the hypothesis that white matter lesions (WML) are primarily associated with regional frontal cortical volumes, and to determine the mediating effects of these regional frontal cortices on the associations of WML with depress...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2012-08-01
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| Series: | BMC Neurology |
| Subjects: | |
| Online Access: | http://www.biomedcentral.com/1471-2377/12/83 |
| _version_ | 1818806341571969024 |
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| author | Lee Jun-Young Insel Philip Mackin R Schuff Norbert Chui Helena DeCarli Charles Park Kee Mueller Susanne G Weiner Michael W |
| author_facet | Lee Jun-Young Insel Philip Mackin R Schuff Norbert Chui Helena DeCarli Charles Park Kee Mueller Susanne G Weiner Michael W |
| author_sort | Lee Jun-Young |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>To test the hypothesis that white matter lesions (WML) are primarily associated with regional frontal cortical volumes, and to determine the mediating effects of these regional frontal cortices on the associations of WML with depressive symptoms and cognitive dysfunction.</p> <p>Methods</p> <p>Structural brains MRIs were performed on 161 participants: cognitively normal, cognitive impaired but not demented, and demented participants. Lobar WML volumes, regional frontal cortical volumes, depressive symptom severity, and cognitive abilities were measured. Multiple linear regression analyses were used to identify WML volume effects on frontal cortical volume. Structural equation modeling was used to determine the MRI-depression and the MRI-cognition path relationships.</p> <p>Results</p> <p>WML predicted frontal cortical volume, particularly in medial orbirtofrontal cortex, irrespective of age, gender, education, and group status. WML directly predicted depressive score, and this relationship was not mediated by regional frontal cortices. In contrast, the association between WML and cognitive function was indirect and mediated by regional frontal cortices.</p> <p>Conclusions</p> <p>These findings suggest that the neurobiological mechanisms underpinning depressive symptoms and cognitive dysfunction in older adults may differ.</p> |
| first_indexed | 2024-12-18T19:08:14Z |
| format | Article |
| id | doaj.art-a4c7d7bca66846aa8eeebec6501ed852 |
| institution | Directory Open Access Journal |
| issn | 1471-2377 |
| language | English |
| last_indexed | 2024-12-18T19:08:14Z |
| publishDate | 2012-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Neurology |
| spelling | doaj.art-a4c7d7bca66846aa8eeebec6501ed8522022-12-21T20:56:22ZengBMCBMC Neurology1471-23772012-08-011218310.1186/1471-2377-12-83Different associations of white matter lesions with depression and cognitionLee Jun-YoungInsel PhilipMackin RSchuff NorbertChui HelenaDeCarli CharlesPark KeeMueller Susanne GWeiner Michael W<p>Abstract</p> <p>Background</p> <p>To test the hypothesis that white matter lesions (WML) are primarily associated with regional frontal cortical volumes, and to determine the mediating effects of these regional frontal cortices on the associations of WML with depressive symptoms and cognitive dysfunction.</p> <p>Methods</p> <p>Structural brains MRIs were performed on 161 participants: cognitively normal, cognitive impaired but not demented, and demented participants. Lobar WML volumes, regional frontal cortical volumes, depressive symptom severity, and cognitive abilities were measured. Multiple linear regression analyses were used to identify WML volume effects on frontal cortical volume. Structural equation modeling was used to determine the MRI-depression and the MRI-cognition path relationships.</p> <p>Results</p> <p>WML predicted frontal cortical volume, particularly in medial orbirtofrontal cortex, irrespective of age, gender, education, and group status. WML directly predicted depressive score, and this relationship was not mediated by regional frontal cortices. In contrast, the association between WML and cognitive function was indirect and mediated by regional frontal cortices.</p> <p>Conclusions</p> <p>These findings suggest that the neurobiological mechanisms underpinning depressive symptoms and cognitive dysfunction in older adults may differ.</p>http://www.biomedcentral.com/1471-2377/12/83LeukoaraiosisDepressionCognitionFrontal lobeMediation |
| spellingShingle | Lee Jun-Young Insel Philip Mackin R Schuff Norbert Chui Helena DeCarli Charles Park Kee Mueller Susanne G Weiner Michael W Different associations of white matter lesions with depression and cognition BMC Neurology Leukoaraiosis Depression Cognition Frontal lobe Mediation |
| title | Different associations of white matter lesions with depression and cognition |
| title_full | Different associations of white matter lesions with depression and cognition |
| title_fullStr | Different associations of white matter lesions with depression and cognition |
| title_full_unstemmed | Different associations of white matter lesions with depression and cognition |
| title_short | Different associations of white matter lesions with depression and cognition |
| title_sort | different associations of white matter lesions with depression and cognition |
| topic | Leukoaraiosis Depression Cognition Frontal lobe Mediation |
| url | http://www.biomedcentral.com/1471-2377/12/83 |
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