Specific features of the course of duodenal ulcer in bronchial asthma (clinical and pathomorphological aspects)
Aim. To study incidence of gastroduodenal ulcer (GDU) in bronchial asthma and clinicomorphological features of ulcer disease in BA in long-term use of systemic corticosteroids (SCS) and without SCS. Material and methods. The trial covered 297 BA patients. They have undergone clinicoendoscopic examin...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
"Consilium Medicum" Publishing house
2004-01-01
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| Series: | Терапевтический архив |
| Subjects: | |
| Online Access: | https://ter-arkhiv.ru/0040-3660/article/view/29772 |
| _version_ | 1828389272098439168 |
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| author | G M Chernyavskaya R I Pleshko E I Beloborodova I V Sukhodolo E V Plekhanova |
| author_facet | G M Chernyavskaya R I Pleshko E I Beloborodova I V Sukhodolo E V Plekhanova |
| author_sort | G M Chernyavskaya |
| collection | DOAJ |
| description | Aim. To study incidence of gastroduodenal ulcer (GDU) in bronchial asthma and clinicomorphological features of ulcer disease in BA in long-term use of systemic corticosteroids (SCS) and without SCS. Material and methods. The trial covered 297 BA patients. They have undergone clinicoendoscopic examination of the gastroduodenal zone (GDZ) for duodenal ulcer with assessment of clinical gastroenterological symptoms and morphological analysis of bipsies of gastric and duodenal mucosa using histological, histochemical and morphometric methods.
Results. BA patients were found to have high incidence of duodenal ulcer (21.9%). Morphologically, they had active immune inflammation with hyperergic component.
The results of the study did not confirm the opinion about a key role of SCS in development of GDU in BA. Small doses of SCS in patients with BA and GDU do not deteriorate ulcerogenesis. Conclusion. One of the factors determining combination of ulcer disease with В A may be chronic hyperergic inflammation of GDZ mucosa stimulating realization of predisposition to ulcer and its chronic recurrent course. |
| first_indexed | 2024-12-10T06:28:25Z |
| format | Article |
| id | doaj.art-a4c852ef19254342b1d0e93def1de1a7 |
| institution | Directory Open Access Journal |
| issn | 0040-3660 2309-5342 |
| language | Russian |
| last_indexed | 2024-12-10T06:28:25Z |
| publishDate | 2004-01-01 |
| publisher | "Consilium Medicum" Publishing house |
| record_format | Article |
| series | Терапевтический архив |
| spelling | doaj.art-a4c852ef19254342b1d0e93def1de1a72022-12-22T01:59:10Zrus"Consilium Medicum" Publishing houseТерапевтический архив0040-36602309-53422004-01-01791586226800Specific features of the course of duodenal ulcer in bronchial asthma (clinical and pathomorphological aspects)G M ChernyavskayaR I PleshkoE I BeloborodovaI V SukhodoloE V PlekhanovaAim. To study incidence of gastroduodenal ulcer (GDU) in bronchial asthma and clinicomorphological features of ulcer disease in BA in long-term use of systemic corticosteroids (SCS) and without SCS. Material and methods. The trial covered 297 BA patients. They have undergone clinicoendoscopic examination of the gastroduodenal zone (GDZ) for duodenal ulcer with assessment of clinical gastroenterological symptoms and morphological analysis of bipsies of gastric and duodenal mucosa using histological, histochemical and morphometric methods. Results. BA patients were found to have high incidence of duodenal ulcer (21.9%). Morphologically, they had active immune inflammation with hyperergic component. The results of the study did not confirm the opinion about a key role of SCS in development of GDU in BA. Small doses of SCS in patients with BA and GDU do not deteriorate ulcerogenesis. Conclusion. One of the factors determining combination of ulcer disease with В A may be chronic hyperergic inflammation of GDZ mucosa stimulating realization of predisposition to ulcer and its chronic recurrent course.https://ter-arkhiv.ru/0040-3660/article/view/29772bronchial asthmagastroduodenal zoneulcer diseaseinfiltration of gastric mucosasystemic glucocorticosteroids |
| spellingShingle | G M Chernyavskaya R I Pleshko E I Beloborodova I V Sukhodolo E V Plekhanova Specific features of the course of duodenal ulcer in bronchial asthma (clinical and pathomorphological aspects) Терапевтический архив bronchial asthma gastroduodenal zone ulcer disease infiltration of gastric mucosa systemic glucocorticosteroids |
| title | Specific features of the course of duodenal ulcer in bronchial asthma (clinical and pathomorphological aspects) |
| title_full | Specific features of the course of duodenal ulcer in bronchial asthma (clinical and pathomorphological aspects) |
| title_fullStr | Specific features of the course of duodenal ulcer in bronchial asthma (clinical and pathomorphological aspects) |
| title_full_unstemmed | Specific features of the course of duodenal ulcer in bronchial asthma (clinical and pathomorphological aspects) |
| title_short | Specific features of the course of duodenal ulcer in bronchial asthma (clinical and pathomorphological aspects) |
| title_sort | specific features of the course of duodenal ulcer in bronchial asthma clinical and pathomorphological aspects |
| topic | bronchial asthma gastroduodenal zone ulcer disease infiltration of gastric mucosa systemic glucocorticosteroids |
| url | https://ter-arkhiv.ru/0040-3660/article/view/29772 |
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