Population Pharmacokinetic Analysis Proves Superiority of Continuous Infusion in PK/PD Target Attainment with Oxacillin in Staphylococcal Infections

Population Pharmacokinetic Analysis Proves Superiority of Continuous Infusion in PK/PD Target Attainment with Oxacillin in Staphylococcal Infections

Considering its very short elimination half-life, the approved oxacillin dosage might not be sufficient to maintain the pharmacokinetic/pharmacodynamics (PK/PD) target of time-dependent antibiotics. This study aimed to describe the population pharmacokinetics of oxacillin and to explore the probabil...

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Bibliographic Details
Main Authors: Irena Murínová, Martin Švidrnoch, Tomáš Gucký, Jan Hlaváč, Pavel Michálek, Ondřej Slanař, Martin Šíma
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Antibiotics
Subjects:
antibiotics
nonlinear mixed-effects modeling
glomerular filtration rate
dosing regimen
oxacillin
Monte Carlo simulations
Online Access:https://www.mdpi.com/2079-6382/11/12/1736

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