Humanized tau antibodies promote tau uptake by human microglia without any increase of inflammation

Humanized tau antibodies promote tau uptake by human microglia without any increase of inflammation

Abstract Immunotherapies targeting pathological tau have recently emerged as a promising approach for treatment of neurodegenerative disorders. We have previously showed that the mouse antibody DC8E8 discriminates between healthy and pathological tau, reduces tau pathology in murine tauopathy models...

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Bibliographic Details
Main Authors: Monika Zilkova, Anna Nolle, Branislav Kovacech, Eva Kontsekova, Petronela Weisova, Peter Filipcik, Rostislav Skrabana, Michal Prcina, Tomas Hromadka, Ondrej Cehlar, Gabriela Paulikova Rolkova, Denisa Maderova, Michal Novak, Norbert Zilka, Jeroen J. M. Hoozemans
Format: Article
Language:English
Published: BMC 2020-05-01
Series:Acta Neuropathologica Communications
Subjects:
Tau immunotherapy
Humanized antibody
Human microglia
Tau uptake
Online Access:http://link.springer.com/article/10.1186/s40478-020-00948-z

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