Propranolol versus Other Selected Drugs in the Treatment of Various Types of Anxiety or Stress, with Particular Reference to Stage Fright and Post-Traumatic Stress Disorder
Propranolol, a non-cardioselective β<sub>1,2</sub> blocker, is most commonly recognised for its application in the therapy of various cardiovascular conditions, such as hypertension, coronary artery disease, and tachyarrhythmias. However, due to its ability to cross the blood–brain barri...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-09-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/17/10099 |
| _version_ | 1797494950831587328 |
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| author | Łukasz Szeleszczuk Dawid Frączkowski |
| author_facet | Łukasz Szeleszczuk Dawid Frączkowski |
| author_sort | Łukasz Szeleszczuk |
| collection | DOAJ |
| description | Propranolol, a non-cardioselective β<sub>1,2</sub> blocker, is most commonly recognised for its application in the therapy of various cardiovascular conditions, such as hypertension, coronary artery disease, and tachyarrhythmias. However, due to its ability to cross the blood–brain barrier and affinity towards multiple macromolecules, not only adrenoreceptors, it has also found application in other fields. For example, it is one of the very few medications successfully applied in the treatment of stage fright. This review focuses on the application of propranolol in the treatment of various types of anxiety and stress, with particular reference to stage fright and post-traumatic stress disorder (PTSD). Both mechanisms of action as well as comparison with other therapies are presented. As those indications for propranolol are, in most countries, considered off-label, this review aims to gather information that can be useful while making a decision about the choice of propranolol as a drug in the treatment of those mental conditions. |
| first_indexed | 2024-03-10T01:41:36Z |
| format | Article |
| id | doaj.art-a4c9707de1d94f8e9a1c4312a3a35509 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T01:41:36Z |
| publishDate | 2022-09-01 |
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| series | International Journal of Molecular Sciences |
| spelling | doaj.art-a4c9707de1d94f8e9a1c4312a3a355092023-11-23T13:22:51ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-09-0123171009910.3390/ijms231710099Propranolol versus Other Selected Drugs in the Treatment of Various Types of Anxiety or Stress, with Particular Reference to Stage Fright and Post-Traumatic Stress DisorderŁukasz Szeleszczuk0Dawid Frączkowski1Department of Physical Chemistry, Chair and Department of Physical Pharmacy and Bioanalysis, Faculty of Pharmacy, Medical University of Warsaw, Banacha 1 Street, 02-093 Warsaw, PolandDepartment of Physical Chemistry, Chair and Department of Physical Pharmacy and Bioanalysis, Faculty of Pharmacy, Medical University of Warsaw, Banacha 1 Street, 02-093 Warsaw, PolandPropranolol, a non-cardioselective β<sub>1,2</sub> blocker, is most commonly recognised for its application in the therapy of various cardiovascular conditions, such as hypertension, coronary artery disease, and tachyarrhythmias. However, due to its ability to cross the blood–brain barrier and affinity towards multiple macromolecules, not only adrenoreceptors, it has also found application in other fields. For example, it is one of the very few medications successfully applied in the treatment of stage fright. This review focuses on the application of propranolol in the treatment of various types of anxiety and stress, with particular reference to stage fright and post-traumatic stress disorder (PTSD). Both mechanisms of action as well as comparison with other therapies are presented. As those indications for propranolol are, in most countries, considered off-label, this review aims to gather information that can be useful while making a decision about the choice of propranolol as a drug in the treatment of those mental conditions.https://www.mdpi.com/1422-0067/23/17/10099propranololanxietystage frightPTSDpost-traumatic stress disorder |
| spellingShingle | Łukasz Szeleszczuk Dawid Frączkowski Propranolol versus Other Selected Drugs in the Treatment of Various Types of Anxiety or Stress, with Particular Reference to Stage Fright and Post-Traumatic Stress Disorder International Journal of Molecular Sciences propranolol anxiety stage fright PTSD post-traumatic stress disorder |
| title | Propranolol versus Other Selected Drugs in the Treatment of Various Types of Anxiety or Stress, with Particular Reference to Stage Fright and Post-Traumatic Stress Disorder |
| title_full | Propranolol versus Other Selected Drugs in the Treatment of Various Types of Anxiety or Stress, with Particular Reference to Stage Fright and Post-Traumatic Stress Disorder |
| title_fullStr | Propranolol versus Other Selected Drugs in the Treatment of Various Types of Anxiety or Stress, with Particular Reference to Stage Fright and Post-Traumatic Stress Disorder |
| title_full_unstemmed | Propranolol versus Other Selected Drugs in the Treatment of Various Types of Anxiety or Stress, with Particular Reference to Stage Fright and Post-Traumatic Stress Disorder |
| title_short | Propranolol versus Other Selected Drugs in the Treatment of Various Types of Anxiety or Stress, with Particular Reference to Stage Fright and Post-Traumatic Stress Disorder |
| title_sort | propranolol versus other selected drugs in the treatment of various types of anxiety or stress with particular reference to stage fright and post traumatic stress disorder |
| topic | propranolol anxiety stage fright PTSD post-traumatic stress disorder |
| url | https://www.mdpi.com/1422-0067/23/17/10099 |
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