New insights into the roles of oligodendrocytes regulation in ischemic stroke recovery
Oligodendrocytes (OLs), the myelin-forming cells of the central nervous system, are integral to axonal integrity and function. Hypoxia-ischemia episodes can cause severe damage to these vulnerable cells through excitotoxicity, oxidative stress, inflammation, and mitochondrial dysfunction, leading to...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-08-01
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| Series: | Neurobiology of Disease |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0969996123002152 |
| _version_ | 1797755834870005760 |
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| author | Shuangfeng Huang Changhong Ren Yumin Luo Yuchuan Ding Xunming Ji Sijie Li |
| author_facet | Shuangfeng Huang Changhong Ren Yumin Luo Yuchuan Ding Xunming Ji Sijie Li |
| author_sort | Shuangfeng Huang |
| collection | DOAJ |
| description | Oligodendrocytes (OLs), the myelin-forming cells of the central nervous system, are integral to axonal integrity and function. Hypoxia-ischemia episodes can cause severe damage to these vulnerable cells through excitotoxicity, oxidative stress, inflammation, and mitochondrial dysfunction, leading to axonal dystrophy, neuronal dysfunction, and neurological impairments. OLs damage can result in demyelination and myelination disorders, severely impacting axonal function, structure, metabolism, and survival. Adult-onset stroke, periventricular leukomalacia, and post-stroke cognitive impairment primarily target OLs, making them a critical therapeutic target. Therapeutic strategies targeting OLs, myelin, and their receptors should be given more emphasis to attenuate ischemia injury and establish functional recovery after stroke. This review summarizes recent advances on the function of OLs in ischemic injury, as well as the present and emerging principles that serve as the foundation for protective strategies against OLs deaths. |
| first_indexed | 2024-03-12T17:51:47Z |
| format | Article |
| id | doaj.art-a4ca1768aba748f0b6db5b316b70e65d |
| institution | Directory Open Access Journal |
| issn | 1095-953X |
| language | English |
| last_indexed | 2024-03-12T17:51:47Z |
| publishDate | 2023-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Neurobiology of Disease |
| spelling | doaj.art-a4ca1768aba748f0b6db5b316b70e65d2023-08-03T04:22:45ZengElsevierNeurobiology of Disease1095-953X2023-08-01184106200New insights into the roles of oligodendrocytes regulation in ischemic stroke recoveryShuangfeng Huang0Changhong Ren1Yumin Luo2Yuchuan Ding3Xunming Ji4Sijie Li5Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China; Department of Emergency, Xuanwu Hospital, Capital Medical University, Beijing, ChinaBeijing Institute of Brain Disorders, Capital Medical University, Beijing, China; Beijing Key Laboratory of Hypoxic Conditioning Translational Medicine, Xuanwu Hospital, Capital Medical University, Beijing, ChinaBeijing Institute of Brain Disorders, Capital Medical University, Beijing, China; Institute of Cerebrovascular Diseases Research and Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, ChinaDepartment of Neurosurgery, Wayne State University, Detroit, MI, USABeijing Institute of Brain Disorders, Capital Medical University, Beijing, China; Beijing Key Laboratory of Hypoxic Conditioning Translational Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China; Xunming Ji, Beijing Institute of Brain Disorders, Capital Medical University, 10 Xitoutiao, Youanmenwai, Fengtai District, Beijing 100069, China.Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China; Department of Emergency, Xuanwu Hospital, Capital Medical University, Beijing, China; Beijing Institute of Brain Disorders, Capital Medical University, Beijing, China; Correspondence to:Sijie Li, Department of Emergency, Xuanwu Hospital, Capital Medical University, No 45, Changchun Street, Xicheng District, Beijing 100053, China.Oligodendrocytes (OLs), the myelin-forming cells of the central nervous system, are integral to axonal integrity and function. Hypoxia-ischemia episodes can cause severe damage to these vulnerable cells through excitotoxicity, oxidative stress, inflammation, and mitochondrial dysfunction, leading to axonal dystrophy, neuronal dysfunction, and neurological impairments. OLs damage can result in demyelination and myelination disorders, severely impacting axonal function, structure, metabolism, and survival. Adult-onset stroke, periventricular leukomalacia, and post-stroke cognitive impairment primarily target OLs, making them a critical therapeutic target. Therapeutic strategies targeting OLs, myelin, and their receptors should be given more emphasis to attenuate ischemia injury and establish functional recovery after stroke. This review summarizes recent advances on the function of OLs in ischemic injury, as well as the present and emerging principles that serve as the foundation for protective strategies against OLs deaths.http://www.sciencedirect.com/science/article/pii/S0969996123002152OligodendrocytesIschemic strokeWhite matter injuryRemyelinationTherapy |
| spellingShingle | Shuangfeng Huang Changhong Ren Yumin Luo Yuchuan Ding Xunming Ji Sijie Li New insights into the roles of oligodendrocytes regulation in ischemic stroke recovery Neurobiology of Disease Oligodendrocytes Ischemic stroke White matter injury Remyelination Therapy |
| title | New insights into the roles of oligodendrocytes regulation in ischemic stroke recovery |
| title_full | New insights into the roles of oligodendrocytes regulation in ischemic stroke recovery |
| title_fullStr | New insights into the roles of oligodendrocytes regulation in ischemic stroke recovery |
| title_full_unstemmed | New insights into the roles of oligodendrocytes regulation in ischemic stroke recovery |
| title_short | New insights into the roles of oligodendrocytes regulation in ischemic stroke recovery |
| title_sort | new insights into the roles of oligodendrocytes regulation in ischemic stroke recovery |
| topic | Oligodendrocytes Ischemic stroke White matter injury Remyelination Therapy |
| url | http://www.sciencedirect.com/science/article/pii/S0969996123002152 |
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