A Multiscale View of the Mechanisms Underlying Ketamine’s Antidepressant Effects: An Update on Neuronal Calcium Signaling

A Multiscale View of the Mechanisms Underlying Ketamine’s Antidepressant Effects: An Update on Neuronal Calcium Signaling

Major depressive disorder (MDD) is a debilitating disease characterized by depressed mood, loss of interest or pleasure, suicidal ideation, and reduced motivation or hopelessness. Despite considerable research, mechanisms underlying MDD remain poorly understood, and current advances in treatment are...

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Bibliographic Details
Main Authors: Ayako Kawatake-Kuno, Toshiya Murai, Shusaku Uchida
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Behavioral Neuroscience
Subjects:
ketamine
antidepressant action
neuroplasticity
epigenetics
gene expression
stress
Online Access:https://www.frontiersin.org/articles/10.3389/fnbeh.2021.749180/full

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