Causes of microcephaly in human—theoretical considerations
As is evident from the theme of the Research Topic “Small Size, Big Problem: Understanding the Molecular Orchestra of Brain Development from Microcephaly,” the pathomechanisms leading to mirocephaly in human are at best partially understood. As molecular cell biologists and developmental neurobiolog...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-11-01
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| Series: | Frontiers in Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2023.1306166/full |
| _version_ | 1797506326181445632 |
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| author | Michael Heide Wieland B. Huttner |
| author_facet | Michael Heide Wieland B. Huttner |
| author_sort | Michael Heide |
| collection | DOAJ |
| description | As is evident from the theme of the Research Topic “Small Size, Big Problem: Understanding the Molecular Orchestra of Brain Development from Microcephaly,” the pathomechanisms leading to mirocephaly in human are at best partially understood. As molecular cell biologists and developmental neurobiologists, we present here a treatise with theoretical considerations that systematically dissect possible causes of microcephaly, which we believe is timely. Our considerations address the cell types affected in microcephaly, that is, the cortical stem and progenitor cells as well as the neurons and macroglial cell generated therefrom. We discuss issues such as progenitor cell types, cell lineages, modes of cell division, cell proliferation and cell survival. We support our theoretical considerations by discussing selected examples of factual cases of microcephaly, in order to point out that there is a much larger range of possible pathomechanisms leading to microcephaly in human than currently known. |
| first_indexed | 2024-03-10T04:31:04Z |
| format | Article |
| id | doaj.art-a4cf26ef57b5413a98dfc44f1df59344 |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-03-10T04:31:04Z |
| publishDate | 2023-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-a4cf26ef57b5413a98dfc44f1df593442023-11-23T04:45:06ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2023-11-011710.3389/fnins.2023.13061661306166Causes of microcephaly in human—theoretical considerationsMichael Heide0Wieland B. Huttner1German Primate Center, Leibniz Institute for Primate Research, Göttingen, GermanyMax Planck Institute of Molecular Cell Biology and Genetics, Dresden, GermanyAs is evident from the theme of the Research Topic “Small Size, Big Problem: Understanding the Molecular Orchestra of Brain Development from Microcephaly,” the pathomechanisms leading to mirocephaly in human are at best partially understood. As molecular cell biologists and developmental neurobiologists, we present here a treatise with theoretical considerations that systematically dissect possible causes of microcephaly, which we believe is timely. Our considerations address the cell types affected in microcephaly, that is, the cortical stem and progenitor cells as well as the neurons and macroglial cell generated therefrom. We discuss issues such as progenitor cell types, cell lineages, modes of cell division, cell proliferation and cell survival. We support our theoretical considerations by discussing selected examples of factual cases of microcephaly, in order to point out that there is a much larger range of possible pathomechanisms leading to microcephaly in human than currently known.https://www.frontiersin.org/articles/10.3389/fnins.2023.1306166/fullbasal progenitorscortical stem and progenitor cellscell lineagescell divisionZika virus |
| spellingShingle | Michael Heide Wieland B. Huttner Causes of microcephaly in human—theoretical considerations Frontiers in Neuroscience basal progenitors cortical stem and progenitor cells cell lineages cell division Zika virus |
| title | Causes of microcephaly in human—theoretical considerations |
| title_full | Causes of microcephaly in human—theoretical considerations |
| title_fullStr | Causes of microcephaly in human—theoretical considerations |
| title_full_unstemmed | Causes of microcephaly in human—theoretical considerations |
| title_short | Causes of microcephaly in human—theoretical considerations |
| title_sort | causes of microcephaly in human theoretical considerations |
| topic | basal progenitors cortical stem and progenitor cells cell lineages cell division Zika virus |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2023.1306166/full |
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