Thromboembolic Prophylaxis for Total Knee Arthroplasty in Asian Patients: A Randomised Controlled Trial
Purpose. To compare the efficacy and safety of different modes of thromboembolic prophylaxis for elective total knee arthroplasty (TKA) in Asian patients. Methods. 440 low-risk patients undergoing TKA were randomised into 4 equal groups: (1) no prophylaxis (control), (2) graduated compression stocki...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2009-04-01
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| Series: | Journal of Orthopaedic Surgery |
| Online Access: | https://doi.org/10.1177/230949900901700101 |
| _version_ | 1818160043458035712 |
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| author | PL Chin MS Amin KY Yang SJ Yeo NN Lo |
| author_facet | PL Chin MS Amin KY Yang SJ Yeo NN Lo |
| author_sort | PL Chin |
| collection | DOAJ |
| description | Purpose. To compare the efficacy and safety of different modes of thromboembolic prophylaxis for elective total knee arthroplasty (TKA) in Asian patients. Methods. 440 low-risk patients undergoing TKA were randomised into 4 equal groups: (1) no prophylaxis (control), (2) graduated compression stockings (GCS), (3) intermittent pneumatic compression (IPC), and (4) low-molecular-weight heparin (enoxaparin). Duplex ultrasonography was used as an assessment tool. Results. The deep vein thrombosis point prevalence was highest in the control group (22%), which was significantly higher than in patients receiving IPC (8%, p=0.032) or enoxaparin (6%, p=0.001). One patient each in the control and GCS groups developed a non-fatal pulmonary embolism. Patients on enoxaparin received more blood transfusions and 2 of them had major bleeding complications. Conclusion. IPC is the preferred method of thromboprophylaxis for TKA in Asian patients. |
| first_indexed | 2024-12-11T15:55:36Z |
| format | Article |
| id | doaj.art-a4cf4c18a90d4f3487b6fc7ffc7e7d1b |
| institution | Directory Open Access Journal |
| issn | 2309-4990 |
| language | English |
| last_indexed | 2024-12-11T15:55:36Z |
| publishDate | 2009-04-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of Orthopaedic Surgery |
| spelling | doaj.art-a4cf4c18a90d4f3487b6fc7ffc7e7d1b2022-12-22T00:59:27ZengSAGE PublishingJournal of Orthopaedic Surgery2309-49902009-04-011710.1177/230949900901700101Thromboembolic Prophylaxis for Total Knee Arthroplasty in Asian Patients: A Randomised Controlled TrialPL ChinMS AminKY YangSJ YeoNN LoPurpose. To compare the efficacy and safety of different modes of thromboembolic prophylaxis for elective total knee arthroplasty (TKA) in Asian patients. Methods. 440 low-risk patients undergoing TKA were randomised into 4 equal groups: (1) no prophylaxis (control), (2) graduated compression stockings (GCS), (3) intermittent pneumatic compression (IPC), and (4) low-molecular-weight heparin (enoxaparin). Duplex ultrasonography was used as an assessment tool. Results. The deep vein thrombosis point prevalence was highest in the control group (22%), which was significantly higher than in patients receiving IPC (8%, p=0.032) or enoxaparin (6%, p=0.001). One patient each in the control and GCS groups developed a non-fatal pulmonary embolism. Patients on enoxaparin received more blood transfusions and 2 of them had major bleeding complications. Conclusion. IPC is the preferred method of thromboprophylaxis for TKA in Asian patients.https://doi.org/10.1177/230949900901700101 |
| spellingShingle | PL Chin MS Amin KY Yang SJ Yeo NN Lo Thromboembolic Prophylaxis for Total Knee Arthroplasty in Asian Patients: A Randomised Controlled Trial Journal of Orthopaedic Surgery |
| title | Thromboembolic Prophylaxis for Total Knee Arthroplasty in Asian Patients: A Randomised Controlled Trial |
| title_full | Thromboembolic Prophylaxis for Total Knee Arthroplasty in Asian Patients: A Randomised Controlled Trial |
| title_fullStr | Thromboembolic Prophylaxis for Total Knee Arthroplasty in Asian Patients: A Randomised Controlled Trial |
| title_full_unstemmed | Thromboembolic Prophylaxis for Total Knee Arthroplasty in Asian Patients: A Randomised Controlled Trial |
| title_short | Thromboembolic Prophylaxis for Total Knee Arthroplasty in Asian Patients: A Randomised Controlled Trial |
| title_sort | thromboembolic prophylaxis for total knee arthroplasty in asian patients a randomised controlled trial |
| url | https://doi.org/10.1177/230949900901700101 |
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