The role of surface functionalization of silica nanoparticles for bioimaging
Among the several types of inorganic nanoparticles available, silica nanoparticles (SNP) have earned their relevance in biological applications namely, as bioimaging agents. In fact, fluorescent SNP (FSNP) have been explored in this field as protective nanocarriers, overcoming some limitations prese...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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World Scientific Publishing
2016-07-01
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| Series: | Journal of Innovative Optical Health Sciences |
| Subjects: | |
| Online Access: | http://www.worldscientific.com/doi/pdf/10.1142/S1793545816300056 |
| _version_ | 1818172084540407808 |
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| author | Maria C. Gomes Ângela Cunha Tito Trindade João P. C. Tomé |
| author_facet | Maria C. Gomes Ângela Cunha Tito Trindade João P. C. Tomé |
| author_sort | Maria C. Gomes |
| collection | DOAJ |
| description | Among the several types of inorganic nanoparticles available, silica nanoparticles (SNP) have earned their relevance in biological applications namely, as bioimaging agents. In fact, fluorescent SNP (FSNP) have been explored in this field as protective nanocarriers, overcoming some limitations presented by conventional organic dyes such as high photobleaching rates. A crucial aspect on the use of fluorescent SNP relates to their surface properties, since it determines the extent of interaction between nanoparticles and biological systems, namely in terms of colloidal stability in water, cellular recognition and internalization, tracking, biodistribution and specificity, among others. Therefore, it is imperative to understand the mechanisms underlying the interaction between biosystems and the SNP surfaces, making surface functionalization a relevant step in order to take full advantage of particle properties. The versatility of the surface chemistry on silica platforms, together with the intrinsic hydrophilicity and biocompatibility, make these systems suitable for bioimaging applications, such as those mentioned in this review. |
| first_indexed | 2024-12-11T19:06:59Z |
| format | Article |
| id | doaj.art-a4d002f62d9f4820bfc510560f0840df |
| institution | Directory Open Access Journal |
| issn | 1793-5458 1793-7205 |
| language | English |
| last_indexed | 2024-12-11T19:06:59Z |
| publishDate | 2016-07-01 |
| publisher | World Scientific Publishing |
| record_format | Article |
| series | Journal of Innovative Optical Health Sciences |
| spelling | doaj.art-a4d002f62d9f4820bfc510560f0840df2022-12-22T00:53:52ZengWorld Scientific PublishingJournal of Innovative Optical Health Sciences1793-54581793-72052016-07-01941630005-11630005-1610.1142/S179354581630005610.1142/S1793545816300056The role of surface functionalization of silica nanoparticles for bioimagingMaria C. Gomes0Ângela Cunha1Tito Trindade2João P. C. Tomé3QOPNA and Department of Chemistry, University of Aveiro, 3810-193 Aveiro, PortugalCESAM and Department of Biology, University of Aveiro, 3810-193 Aveiro, PortugalCICECO and Department of Chemistry, University of Aveiro, 3810-193 Aveiro, PortugalQOPNA and Department of Chemistry, University of Aveiro, 3810-193 Aveiro, PortugalAmong the several types of inorganic nanoparticles available, silica nanoparticles (SNP) have earned their relevance in biological applications namely, as bioimaging agents. In fact, fluorescent SNP (FSNP) have been explored in this field as protective nanocarriers, overcoming some limitations presented by conventional organic dyes such as high photobleaching rates. A crucial aspect on the use of fluorescent SNP relates to their surface properties, since it determines the extent of interaction between nanoparticles and biological systems, namely in terms of colloidal stability in water, cellular recognition and internalization, tracking, biodistribution and specificity, among others. Therefore, it is imperative to understand the mechanisms underlying the interaction between biosystems and the SNP surfaces, making surface functionalization a relevant step in order to take full advantage of particle properties. The versatility of the surface chemistry on silica platforms, together with the intrinsic hydrophilicity and biocompatibility, make these systems suitable for bioimaging applications, such as those mentioned in this review.http://www.worldscientific.com/doi/pdf/10.1142/S1793545816300056Fluorescent silica nanoparticlesbioimagingsurface functionalizationnanoparticle-cell interactions |
| spellingShingle | Maria C. Gomes Ângela Cunha Tito Trindade João P. C. Tomé The role of surface functionalization of silica nanoparticles for bioimaging Journal of Innovative Optical Health Sciences Fluorescent silica nanoparticles bioimaging surface functionalization nanoparticle-cell interactions |
| title | The role of surface functionalization of silica nanoparticles for bioimaging |
| title_full | The role of surface functionalization of silica nanoparticles for bioimaging |
| title_fullStr | The role of surface functionalization of silica nanoparticles for bioimaging |
| title_full_unstemmed | The role of surface functionalization of silica nanoparticles for bioimaging |
| title_short | The role of surface functionalization of silica nanoparticles for bioimaging |
| title_sort | role of surface functionalization of silica nanoparticles for bioimaging |
| topic | Fluorescent silica nanoparticles bioimaging surface functionalization nanoparticle-cell interactions |
| url | http://www.worldscientific.com/doi/pdf/10.1142/S1793545816300056 |
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