Structural Brain Changes in Blepharospasm: A Cortical Thickness and Diffusion Tensor Imaging Study
White matter abnormalities in blepharospasm (BSP) have been evaluated using conventional intra-voxel metrics, and changes in patterns of cortical thickness in BSP remain controversial. We aimed to determine whether local diffusion homogeneity, an inter-voxel diffusivity metric, could be valuable in...
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Frontiers Media S.A.
2020-10-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2020.543802/full |
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| author | Yaomin Guo Kangqiang Peng Zilin Ou Linchang Zhong Ying Wang Chuanmiao Xie Jinsheng Zeng Weixi Zhang Gang Liu |
| author_facet | Yaomin Guo Kangqiang Peng Zilin Ou Linchang Zhong Ying Wang Chuanmiao Xie Jinsheng Zeng Weixi Zhang Gang Liu |
| author_sort | Yaomin Guo |
| collection | DOAJ |
| description | White matter abnormalities in blepharospasm (BSP) have been evaluated using conventional intra-voxel metrics, and changes in patterns of cortical thickness in BSP remain controversial. We aimed to determine whether local diffusion homogeneity, an inter-voxel diffusivity metric, could be valuable in detecting white matter abnormalities for BSP; whether these changes are related to disease features; and whether cortical thickness changes occur in BSP patients. Diffusion tensor and structural magnetic resonance imaging were collected for 29 patients with BSP and 30 healthy controls. Intergroup diffusion differences were compared using tract-based spatial statistics analysis and measures of cortical thickness were obtained. The relationship among cortical thickness, diffusion metric in significantly different regions, and behavioral measures were further assessed. There were no significant differences in cortical thickness and fractional anisotropy between the groups. Local diffusion homogeneity was higher in BSP patients than controls, primarily in the left superior longitudinal fasciculus, corpus callosum, left posterior corona radiata, and left posterior thalamic radiata (P < 0.05, family-wise error corrected). The local diffusion homogeneity values in these regions were positively correlated with the Jankovic rating scale (rs = 0.416, P = 0.031) and BSP disability index (rs = 0.453, P = 0.018) in BSP patients. These results suggest that intra- and inter-voxel diffusive parameters are differentially sensitive to detecting BSP-related white matter abnormalities and that local diffusion homogeneity might be useful in assessing disability in BSP patients. |
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| language | English |
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| publishDate | 2020-10-01 |
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| series | Frontiers in Neuroscience |
| spelling | doaj.art-a4d0df4b6d314ae7b8f9471d1cc7b0b72022-12-22T00:09:58ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2020-10-011410.3389/fnins.2020.543802543802Structural Brain Changes in Blepharospasm: A Cortical Thickness and Diffusion Tensor Imaging StudyYaomin Guo0Kangqiang Peng1Zilin Ou2Linchang Zhong3Ying Wang4Chuanmiao Xie5Jinsheng Zeng6Weixi Zhang7Gang Liu8Department of Neurology, The First Affiliated Hospital, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases, National Key Clinical Department and Key Discipline of Neurology, Guangzhou, ChinaDepartment of Medical Imaging, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in Southern China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, ChinaDepartment of Neurology, The First Affiliated Hospital, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases, National Key Clinical Department and Key Discipline of Neurology, Guangzhou, ChinaDepartment of Medical Imaging, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in Southern China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, ChinaDepartment of Neurology, The First Affiliated Hospital, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases, National Key Clinical Department and Key Discipline of Neurology, Guangzhou, ChinaDepartment of Medical Imaging, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in Southern China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, ChinaDepartment of Neurology, The First Affiliated Hospital, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases, National Key Clinical Department and Key Discipline of Neurology, Guangzhou, ChinaDepartment of Neurology, The First Affiliated Hospital, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases, National Key Clinical Department and Key Discipline of Neurology, Guangzhou, ChinaDepartment of Neurology, The First Affiliated Hospital, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases, National Key Clinical Department and Key Discipline of Neurology, Guangzhou, ChinaWhite matter abnormalities in blepharospasm (BSP) have been evaluated using conventional intra-voxel metrics, and changes in patterns of cortical thickness in BSP remain controversial. We aimed to determine whether local diffusion homogeneity, an inter-voxel diffusivity metric, could be valuable in detecting white matter abnormalities for BSP; whether these changes are related to disease features; and whether cortical thickness changes occur in BSP patients. Diffusion tensor and structural magnetic resonance imaging were collected for 29 patients with BSP and 30 healthy controls. Intergroup diffusion differences were compared using tract-based spatial statistics analysis and measures of cortical thickness were obtained. The relationship among cortical thickness, diffusion metric in significantly different regions, and behavioral measures were further assessed. There were no significant differences in cortical thickness and fractional anisotropy between the groups. Local diffusion homogeneity was higher in BSP patients than controls, primarily in the left superior longitudinal fasciculus, corpus callosum, left posterior corona radiata, and left posterior thalamic radiata (P < 0.05, family-wise error corrected). The local diffusion homogeneity values in these regions were positively correlated with the Jankovic rating scale (rs = 0.416, P = 0.031) and BSP disability index (rs = 0.453, P = 0.018) in BSP patients. These results suggest that intra- and inter-voxel diffusive parameters are differentially sensitive to detecting BSP-related white matter abnormalities and that local diffusion homogeneity might be useful in assessing disability in BSP patients.https://www.frontiersin.org/articles/10.3389/fnins.2020.543802/fullblepharospasmcortical thicknessdiffusion tensor imagingfractional anisotropylocal diffusion homogeneity |
| spellingShingle | Yaomin Guo Kangqiang Peng Zilin Ou Linchang Zhong Ying Wang Chuanmiao Xie Jinsheng Zeng Weixi Zhang Gang Liu Structural Brain Changes in Blepharospasm: A Cortical Thickness and Diffusion Tensor Imaging Study Frontiers in Neuroscience blepharospasm cortical thickness diffusion tensor imaging fractional anisotropy local diffusion homogeneity |
| title | Structural Brain Changes in Blepharospasm: A Cortical Thickness and Diffusion Tensor Imaging Study |
| title_full | Structural Brain Changes in Blepharospasm: A Cortical Thickness and Diffusion Tensor Imaging Study |
| title_fullStr | Structural Brain Changes in Blepharospasm: A Cortical Thickness and Diffusion Tensor Imaging Study |
| title_full_unstemmed | Structural Brain Changes in Blepharospasm: A Cortical Thickness and Diffusion Tensor Imaging Study |
| title_short | Structural Brain Changes in Blepharospasm: A Cortical Thickness and Diffusion Tensor Imaging Study |
| title_sort | structural brain changes in blepharospasm a cortical thickness and diffusion tensor imaging study |
| topic | blepharospasm cortical thickness diffusion tensor imaging fractional anisotropy local diffusion homogeneity |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2020.543802/full |
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