Metabolomics and Gene Expression Analysis Reveal Down-regulation of the Citric Acid (TCA) Cycle in Non-diabetic CKD Patients

Metabolomics and Gene Expression Analysis Reveal Down-regulation of the Citric Acid (TCA) Cycle in Non-diabetic CKD Patients

Chronic kidney disease (CKD) is a public health problem with very high prevalence and mortality. Yet, there is a paucity of effective treatment options, partly due to insufficient knowledge of underlying pathophysiology. We combined metabolomics (GCMS) with kidney gene expression studies to identify...

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Bibliographic Details
Main Authors: Stein Hallan, Maryam Afkarian, Leila R. Zelnick, Bryan Kestenbaum, Shoba Sharma, Rintaro Saito, Manjula Darshi, Gregory Barding, Daniel Raftery, Wenjun Ju, Matthias Kretzler, Kumar Sharma, Ian H. de Boer
Format: Article
Language:English
Published: Elsevier 2017-12-01
Series:EBioMedicine
Subjects:
Citric acid cycle
Chronic kidney disease
Metabolomics
Gene expression
Mitochondria
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396417304267

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