A Narrative Review of Preventive Central Lymph Node Dissection in Patients With Papillary Thyroid Cancer - A Necessity or an Excess
ObjectiveThis review article summarises the latest evidence for preventive central lymph node dissection in patients with papillary thyroid cancer taking into account the possible complications and risk of recurrence.BackgroundPapillary thyroid cancer is the most frequent histological variant of mal...
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| Language: | English |
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Frontiers Media S.A.
2022-06-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.906695/full |
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| author | David D. Dolidze David D. Dolidze Alexey V. Shabunin Alexey V. Shabunin Robert B. Mumladze Robert B. Mumladze Arshak V. Vardanyan Arshak V. Vardanyan Serghei D. Covantsev Alexander M. Shulutko Vasiliy I. Semikov Khalid M. Isaev Airazat M. Kazaryan Airazat M. Kazaryan Airazat M. Kazaryan Airazat M. Kazaryan Airazat M. Kazaryan |
| author_facet | David D. Dolidze David D. Dolidze Alexey V. Shabunin Alexey V. Shabunin Robert B. Mumladze Robert B. Mumladze Arshak V. Vardanyan Arshak V. Vardanyan Serghei D. Covantsev Alexander M. Shulutko Vasiliy I. Semikov Khalid M. Isaev Airazat M. Kazaryan Airazat M. Kazaryan Airazat M. Kazaryan Airazat M. Kazaryan Airazat M. Kazaryan |
| author_sort | David D. Dolidze |
| collection | DOAJ |
| description | ObjectiveThis review article summarises the latest evidence for preventive central lymph node dissection in patients with papillary thyroid cancer taking into account the possible complications and risk of recurrence.BackgroundPapillary thyroid cancer is the most frequent histological variant of malignant neoplasms of the thyroid gland. It accounts for about 80-85% of all cases of thyroid cancer. Despite good postoperative results and an excellent survival rate in comparison with many other malignant diseases, tumor metastases to the cervical lymph nodes are frequent. Most researchers agree that the presence of obvious metastases in the lymph nodes requires careful lymph node dissection. It was suggested to perform preventive routine lymphadenectomy in all patients with malignant thyroid diseases referred to surgery.MethodsIt was performed the literature review using the “papillary thyroid cancer”, “central lymph node dissection”, “hypocalcemia”, “recurrent laryngeal nerve paresis”, “metastasis”, “cancer recurrence” along with the MESH terms. The reference list of the articles was carefully reviewed as a potential source of information. The search was based on Medline, Scopus, Google Scholar, eLibrary engines. Selected publications were analyzed and their synthesis was used to write the review and analyse the role of preventive central lymph node dissection in patients with papillary thyroid cancer.ConclusionsThe necessity of preventive central lymph node dissection in patients with differentiated papillary thyroid carcinoma is still controversial. There is much evidence that it increases the frequency of transient hypocalcemia. Due to the fact that this complication is temporary, its significance in clinical practice is debatable. It can also be assumed that an extant of surgery in the neck area is associated with an increased risk of recurrent laryngeal nerve injury. However, most studies indicate that this injury is associated more with thyroidectomy itself than with lymph node dissection. Recurrent laryngeal nerve dysfunction is also a temporary complication in the vast majority of cases. At the same time, a large amount of data shows that central lymph node dissection reduces the risk of thyroid cancer recurrence in two times. |
| first_indexed | 2024-12-12T07:16:33Z |
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| id | doaj.art-a4d1a00486624cac8bc2d501f7e6d112 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-12T07:16:33Z |
| publishDate | 2022-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-a4d1a00486624cac8bc2d501f7e6d1122022-12-22T00:33:30ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-06-011210.3389/fonc.2022.906695906695A Narrative Review of Preventive Central Lymph Node Dissection in Patients With Papillary Thyroid Cancer - A Necessity or an ExcessDavid D. Dolidze0David D. Dolidze1Alexey V. Shabunin2Alexey V. Shabunin3Robert B. Mumladze4Robert B. Mumladze5Arshak V. Vardanyan6Arshak V. Vardanyan7Serghei D. Covantsev8Alexander M. Shulutko9Vasiliy I. Semikov10Khalid M. Isaev11Airazat M. Kazaryan12Airazat M. Kazaryan13Airazat M. Kazaryan14Airazat M. Kazaryan15Airazat M. Kazaryan16Department of Surgery, Russian Medical Academy of Continuous Professional Education, Moscow, RussiaDepartment of Surgery, S.P. Botkin City Clinical Hospital, Moscow, RussiaDepartment of Surgery, Russian Medical Academy of Continuous Professional Education, Moscow, RussiaDepartment of Surgery, S.P. Botkin City Clinical Hospital, Moscow, RussiaDepartment of Surgery, Russian Medical Academy of Continuous Professional Education, Moscow, RussiaDepartment of Surgery, S.P. Botkin City Clinical Hospital, Moscow, RussiaDepartment of Surgery, Russian Medical Academy of Continuous Professional Education, Moscow, RussiaDepartment of Surgery, S.P. Botkin City Clinical Hospital, Moscow, RussiaDepartment of Surgery, S.P. Botkin City Clinical Hospital, Moscow, RussiaDepartment of Faculty Surgery №2, I.M.Sechenov First Moscow State Medical University, Moscow, RussiaDepartment of Faculty Surgery №2, I.M.Sechenov First Moscow State Medical University, Moscow, RussiaDepartment of Surgery, Russian Medical Academy of Continuous Professional Education, Moscow, RussiaDepartment of Faculty Surgery №2, I.M.Sechenov First Moscow State Medical University, Moscow, RussiaDepartment of Gastrointestinal Surgery, Østfold Hospital Trust, Grålum, NorwayDepartment of Surgery, Fonna Hospital Trust, Odda, NorwayIntervention Centre, Oslo University Hospital – Rikshospitalet, Oslo, NorwayDepartment of Surgery №1, Yerevan State Medical University after M.Heratsi, Yerevan, ArmeniaObjectiveThis review article summarises the latest evidence for preventive central lymph node dissection in patients with papillary thyroid cancer taking into account the possible complications and risk of recurrence.BackgroundPapillary thyroid cancer is the most frequent histological variant of malignant neoplasms of the thyroid gland. It accounts for about 80-85% of all cases of thyroid cancer. Despite good postoperative results and an excellent survival rate in comparison with many other malignant diseases, tumor metastases to the cervical lymph nodes are frequent. Most researchers agree that the presence of obvious metastases in the lymph nodes requires careful lymph node dissection. It was suggested to perform preventive routine lymphadenectomy in all patients with malignant thyroid diseases referred to surgery.MethodsIt was performed the literature review using the “papillary thyroid cancer”, “central lymph node dissection”, “hypocalcemia”, “recurrent laryngeal nerve paresis”, “metastasis”, “cancer recurrence” along with the MESH terms. The reference list of the articles was carefully reviewed as a potential source of information. The search was based on Medline, Scopus, Google Scholar, eLibrary engines. Selected publications were analyzed and their synthesis was used to write the review and analyse the role of preventive central lymph node dissection in patients with papillary thyroid cancer.ConclusionsThe necessity of preventive central lymph node dissection in patients with differentiated papillary thyroid carcinoma is still controversial. There is much evidence that it increases the frequency of transient hypocalcemia. Due to the fact that this complication is temporary, its significance in clinical practice is debatable. It can also be assumed that an extant of surgery in the neck area is associated with an increased risk of recurrent laryngeal nerve injury. However, most studies indicate that this injury is associated more with thyroidectomy itself than with lymph node dissection. Recurrent laryngeal nerve dysfunction is also a temporary complication in the vast majority of cases. At the same time, a large amount of data shows that central lymph node dissection reduces the risk of thyroid cancer recurrence in two times.https://www.frontiersin.org/articles/10.3389/fonc.2022.906695/fullpapillary thyroid cancerpreventive central lymph node dissectionhypocalcemiarecurrent laryngeal nerve paresismetastasiscancer recurrence |
| spellingShingle | David D. Dolidze David D. Dolidze Alexey V. Shabunin Alexey V. Shabunin Robert B. Mumladze Robert B. Mumladze Arshak V. Vardanyan Arshak V. Vardanyan Serghei D. Covantsev Alexander M. Shulutko Vasiliy I. Semikov Khalid M. Isaev Airazat M. Kazaryan Airazat M. Kazaryan Airazat M. Kazaryan Airazat M. Kazaryan Airazat M. Kazaryan A Narrative Review of Preventive Central Lymph Node Dissection in Patients With Papillary Thyroid Cancer - A Necessity or an Excess Frontiers in Oncology papillary thyroid cancer preventive central lymph node dissection hypocalcemia recurrent laryngeal nerve paresis metastasis cancer recurrence |
| title | A Narrative Review of Preventive Central Lymph Node Dissection in Patients With Papillary Thyroid Cancer - A Necessity or an Excess |
| title_full | A Narrative Review of Preventive Central Lymph Node Dissection in Patients With Papillary Thyroid Cancer - A Necessity or an Excess |
| title_fullStr | A Narrative Review of Preventive Central Lymph Node Dissection in Patients With Papillary Thyroid Cancer - A Necessity or an Excess |
| title_full_unstemmed | A Narrative Review of Preventive Central Lymph Node Dissection in Patients With Papillary Thyroid Cancer - A Necessity or an Excess |
| title_short | A Narrative Review of Preventive Central Lymph Node Dissection in Patients With Papillary Thyroid Cancer - A Necessity or an Excess |
| title_sort | narrative review of preventive central lymph node dissection in patients with papillary thyroid cancer a necessity or an excess |
| topic | papillary thyroid cancer preventive central lymph node dissection hypocalcemia recurrent laryngeal nerve paresis metastasis cancer recurrence |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.906695/full |
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