Synthesis of Cyclic Fragrances via Transformations of Alkenes, Alkynes and Enynes: Strategies and Recent Progress
With increasing demand for customized commodities and the greater insight and understanding of olfaction, the synthesis of fragrances with diverse structures and odor characters has become a core task. Recent progress in organic synthesis and catalysis enables the rapid construction of carbocycles a...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-06-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/27/11/3576 |
| _version_ | 1797492440290033664 |
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| author | Zhigeng Lin Baoying Huang Lufeng Ouyang Liyao Zheng |
| author_facet | Zhigeng Lin Baoying Huang Lufeng Ouyang Liyao Zheng |
| author_sort | Zhigeng Lin |
| collection | DOAJ |
| description | With increasing demand for customized commodities and the greater insight and understanding of olfaction, the synthesis of fragrances with diverse structures and odor characters has become a core task. Recent progress in organic synthesis and catalysis enables the rapid construction of carbocycles and heterocycles from readily available unsaturated molecular building blocks, with increased selectivity, atom economy, sustainability and product diversity. In this review, synthetic methods for creating cyclic fragrances, including both natural and synthetic ones, will be discussed, with a focus on the key transformations of alkenes, alkynes, dienes and enynes. Several strategies will be discussed, including cycloaddition, catalytic cyclization, ring-closing metathesis, intramolecular addition, and rearrangement reactions. Representative examples and the featured olfactory investigations will be highlighted, along with some perspectives on future developments in this area. |
| first_indexed | 2024-03-10T01:03:44Z |
| format | Article |
| id | doaj.art-a4d489ed51714b9484d82fbc07686ccf |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T01:03:44Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-a4d489ed51714b9484d82fbc07686ccf2023-11-23T14:31:00ZengMDPI AGMolecules1420-30492022-06-012711357610.3390/molecules27113576Synthesis of Cyclic Fragrances via Transformations of Alkenes, Alkynes and Enynes: Strategies and Recent ProgressZhigeng Lin0Baoying Huang1Lufeng Ouyang2Liyao Zheng3School of Chemistry and Chemical Engineering, Guangzhou University, Guangzhou 510006, ChinaSchool of Chemistry and Chemical Engineering, Guangzhou University, Guangzhou 510006, ChinaSchool of Chemistry and Chemical Engineering, Guangzhou University, Guangzhou 510006, ChinaSchool of Chemistry and Chemical Engineering, Guangzhou University, Guangzhou 510006, ChinaWith increasing demand for customized commodities and the greater insight and understanding of olfaction, the synthesis of fragrances with diverse structures and odor characters has become a core task. Recent progress in organic synthesis and catalysis enables the rapid construction of carbocycles and heterocycles from readily available unsaturated molecular building blocks, with increased selectivity, atom economy, sustainability and product diversity. In this review, synthetic methods for creating cyclic fragrances, including both natural and synthetic ones, will be discussed, with a focus on the key transformations of alkenes, alkynes, dienes and enynes. Several strategies will be discussed, including cycloaddition, catalytic cyclization, ring-closing metathesis, intramolecular addition, and rearrangement reactions. Representative examples and the featured olfactory investigations will be highlighted, along with some perspectives on future developments in this area.https://www.mdpi.com/1420-3049/27/11/3576cyclizationcycloadditioncarbocyclesheterocyclesunsaturated hydrocarbonsnatural fragrances |
| spellingShingle | Zhigeng Lin Baoying Huang Lufeng Ouyang Liyao Zheng Synthesis of Cyclic Fragrances via Transformations of Alkenes, Alkynes and Enynes: Strategies and Recent Progress Molecules cyclization cycloaddition carbocycles heterocycles unsaturated hydrocarbons natural fragrances |
| title | Synthesis of Cyclic Fragrances via Transformations of Alkenes, Alkynes and Enynes: Strategies and Recent Progress |
| title_full | Synthesis of Cyclic Fragrances via Transformations of Alkenes, Alkynes and Enynes: Strategies and Recent Progress |
| title_fullStr | Synthesis of Cyclic Fragrances via Transformations of Alkenes, Alkynes and Enynes: Strategies and Recent Progress |
| title_full_unstemmed | Synthesis of Cyclic Fragrances via Transformations of Alkenes, Alkynes and Enynes: Strategies and Recent Progress |
| title_short | Synthesis of Cyclic Fragrances via Transformations of Alkenes, Alkynes and Enynes: Strategies and Recent Progress |
| title_sort | synthesis of cyclic fragrances via transformations of alkenes alkynes and enynes strategies and recent progress |
| topic | cyclization cycloaddition carbocycles heterocycles unsaturated hydrocarbons natural fragrances |
| url | https://www.mdpi.com/1420-3049/27/11/3576 |
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