Comparison of conjunctival impression cytology in primary open angle glaucoma, ocular hypertension and normal subjects
AIM: To compare the tear functions and the impression cytology scores of the patients with primary open angle glaucoma(POAG), ocular hypertension(OHT)and normal subjects with healthy ocular surface both functionally and clinically.<p>METHODS: Eleven eyes of 11 patients with POAG(mean age: 62.7...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Press of International Journal of Ophthalmology (IJO PRESS)
2015-05-01
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| Series: | Guoji Yanke Zazhi |
| Subjects: | |
| Online Access: | http://ies.ijo.cn/cn_publish/2015/5/201505001.pdf |
| _version_ | 1818886891455381504 |
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| author | Ufuk Elgin Mehmet Citirik Hulya Haksever Emine Sen Faruk Ozturk Huseyin Ustun |
| author_facet | Ufuk Elgin Mehmet Citirik Hulya Haksever Emine Sen Faruk Ozturk Huseyin Ustun |
| author_sort | Ufuk Elgin |
| collection | DOAJ |
| description | AIM: To compare the tear functions and the impression cytology scores of the patients with primary open angle glaucoma(POAG), ocular hypertension(OHT)and normal subjects with healthy ocular surface both functionally and clinically.<p>METHODS: Eleven eyes of 11 patients with POAG(mean age: 62.7±6.1y), 12 eyes of 12 patients(mean age: 62.8±6.4y)with OHT and 12 eyes of 12 normal subjects(mean age: 62.9±6.03y)were included to this prospective study. The patients with POAG and OHT had been recently diagnosed with these diseases and none of them had taken anti-glaucoma treatment before. In addition to conjunctival impression cytology, tear break-up time(TBUT)and basal Schirmer's tests(BST)were performed. Impression cytology specimens of each group were graded and scored in the range of 0-3 according to Nelson's method. Kruskal-Wallis analysis and Dunn's multiple comparison tests were used for statistical analysis.<p>RESULTS: The mean BST values were 10.4±1.3, 10.9±1.2 and 11.1±1.1 mm/5min of POAG, OHT and control groups respectively. The differences among the BST values of the POAG, OHT and control group were not statistically significant(<i>P</i>=0.33). The mean TBUT values were 11.2±1.1, 11.3±1.1 and 11.8±1.2s in POAG, OHT and normal subjects respectively. The differences among the BUT values of the POAG, OHT and control group were not statistically significant(<i>P</i>=0.35). Six eyes(54.5%)revealed grade 0 and 5 eyes(45.5%)revealed grade 1 impression cytology scores in POAG group. Six eyes(50%)revealed grade 0 and 6 eyes(50%)revealed grade 1 impression cytology scores in OHT group and 6 eyes(50%)revealed grade 0 and 6 eyes(50%)revealed grade 1 impression cytology scores in normal subjects(<i>P</i>=0.97).<p>CONCLUSION: Oxidative stress may cause glaucoma, ocular surface diseases, lacrimal gland malfunction and a decrease in mucus secretion ofgoblet cells in all of the body. There were no significant differences between the impression cytology scores of patients with POAG, OHT and normal subjects. |
| first_indexed | 2024-12-19T16:28:32Z |
| format | Article |
| id | doaj.art-a4d4e0ef04e8422eb3173b79cde490ba |
| institution | Directory Open Access Journal |
| issn | 1672-5123 1672-5123 |
| language | English |
| last_indexed | 2024-12-19T16:28:32Z |
| publishDate | 2015-05-01 |
| publisher | Press of International Journal of Ophthalmology (IJO PRESS) |
| record_format | Article |
| series | Guoji Yanke Zazhi |
| spelling | doaj.art-a4d4e0ef04e8422eb3173b79cde490ba2022-12-21T20:14:16ZengPress of International Journal of Ophthalmology (IJO PRESS)Guoji Yanke Zazhi1672-51231672-51232015-05-0115574574910.3980/j.issn.1672-5123.2015.5.01Comparison of conjunctival impression cytology in primary open angle glaucoma, ocular hypertension and normal subjectsUfuk Elgin0Mehmet Citirik1Hulya Haksever2Emine Sen3Faruk Ozturk4Huseyin Ustun5Department of Ophthalmology, Ankara Ulucanlar Eye Research Hospital, Ankara 06240, TurkeyDepartment of Ophthalmology, Ankara Ulucanlar Eye Research Hospital, Ankara 06240, TurkeyDepartment of Pathology, Ankara Training and Research Hospital, Ankara 06340, TurkeyDepartment of Ophthalmology, Ankara Ulucanlar Eye Research Hospital, Ankara 06240, TurkeyDepartment of Ophthalmology, Ankara Ulucanlar Eye Research Hospital, Ankara 06240, TurkeyDepartment of Pathology, Ankara Training and Research Hospital, Ankara 06340, TurkeyAIM: To compare the tear functions and the impression cytology scores of the patients with primary open angle glaucoma(POAG), ocular hypertension(OHT)and normal subjects with healthy ocular surface both functionally and clinically.<p>METHODS: Eleven eyes of 11 patients with POAG(mean age: 62.7±6.1y), 12 eyes of 12 patients(mean age: 62.8±6.4y)with OHT and 12 eyes of 12 normal subjects(mean age: 62.9±6.03y)were included to this prospective study. The patients with POAG and OHT had been recently diagnosed with these diseases and none of them had taken anti-glaucoma treatment before. In addition to conjunctival impression cytology, tear break-up time(TBUT)and basal Schirmer's tests(BST)were performed. Impression cytology specimens of each group were graded and scored in the range of 0-3 according to Nelson's method. Kruskal-Wallis analysis and Dunn's multiple comparison tests were used for statistical analysis.<p>RESULTS: The mean BST values were 10.4±1.3, 10.9±1.2 and 11.1±1.1 mm/5min of POAG, OHT and control groups respectively. The differences among the BST values of the POAG, OHT and control group were not statistically significant(<i>P</i>=0.33). The mean TBUT values were 11.2±1.1, 11.3±1.1 and 11.8±1.2s in POAG, OHT and normal subjects respectively. The differences among the BUT values of the POAG, OHT and control group were not statistically significant(<i>P</i>=0.35). Six eyes(54.5%)revealed grade 0 and 5 eyes(45.5%)revealed grade 1 impression cytology scores in POAG group. Six eyes(50%)revealed grade 0 and 6 eyes(50%)revealed grade 1 impression cytology scores in OHT group and 6 eyes(50%)revealed grade 0 and 6 eyes(50%)revealed grade 1 impression cytology scores in normal subjects(<i>P</i>=0.97).<p>CONCLUSION: Oxidative stress may cause glaucoma, ocular surface diseases, lacrimal gland malfunction and a decrease in mucus secretion ofgoblet cells in all of the body. There were no significant differences between the impression cytology scores of patients with POAG, OHT and normal subjects.http://ies.ijo.cn/cn_publish/2015/5/201505001.pdfconjunctival impression cytologyprimary open angle glaucomaocular hypertension |
| spellingShingle | Ufuk Elgin Mehmet Citirik Hulya Haksever Emine Sen Faruk Ozturk Huseyin Ustun Comparison of conjunctival impression cytology in primary open angle glaucoma, ocular hypertension and normal subjects Guoji Yanke Zazhi conjunctival impression cytology primary open angle glaucoma ocular hypertension |
| title | Comparison of conjunctival impression cytology in primary open angle glaucoma, ocular hypertension and normal subjects |
| title_full | Comparison of conjunctival impression cytology in primary open angle glaucoma, ocular hypertension and normal subjects |
| title_fullStr | Comparison of conjunctival impression cytology in primary open angle glaucoma, ocular hypertension and normal subjects |
| title_full_unstemmed | Comparison of conjunctival impression cytology in primary open angle glaucoma, ocular hypertension and normal subjects |
| title_short | Comparison of conjunctival impression cytology in primary open angle glaucoma, ocular hypertension and normal subjects |
| title_sort | comparison of conjunctival impression cytology in primary open angle glaucoma ocular hypertension and normal subjects |
| topic | conjunctival impression cytology primary open angle glaucoma ocular hypertension |
| url | http://ies.ijo.cn/cn_publish/2015/5/201505001.pdf |
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