Plasmodial Kinase Inhibitors Targeting Malaria: Recent Developments
Recent progress in reducing malaria cases and ensuing deaths is threatened by factors like mutations that induce resistance to artemisinin derivatives. Multiple drugs are currently in clinical trials for malaria treatment, including some with novel mechanisms of action. One of these, MMV390048, is a...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-12-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/25/24/5949 |
| _version_ | 1797544560622043136 |
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| author | Romain Mustière Patrice Vanelle Nicolas Primas |
| author_facet | Romain Mustière Patrice Vanelle Nicolas Primas |
| author_sort | Romain Mustière |
| collection | DOAJ |
| description | Recent progress in reducing malaria cases and ensuing deaths is threatened by factors like mutations that induce resistance to artemisinin derivatives. Multiple drugs are currently in clinical trials for malaria treatment, including some with novel mechanisms of action. One of these, MMV390048, is a plasmodial kinase inhibitor. This review lists the recently developed molecules which target plasmodial kinases. A systematic review of the literature was performed using CAPLUS and MEDLINE databases from 2005 to 2020. It covers a total of 60 articles and describes about one hundred compounds targeting 22 plasmodial kinases. This work highlights the strong potential of compounds targeting plasmodial kinases for future drug therapies. However, the majority of the <i>Plasmodium</i> kinome remains to be explored. |
| first_indexed | 2024-03-10T14:03:09Z |
| format | Article |
| id | doaj.art-a4d77204dbf2470ab8a6407337625c08 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T14:03:09Z |
| publishDate | 2020-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-a4d77204dbf2470ab8a6407337625c082023-11-21T00:58:27ZengMDPI AGMolecules1420-30492020-12-012524594910.3390/molecules25245949Plasmodial Kinase Inhibitors Targeting Malaria: Recent DevelopmentsRomain Mustière0Patrice Vanelle1Nicolas Primas2Aix Marseille Univ, CNRS, ICR UMR 7273, Equipe Pharmaco-Chimie Radicalaire, Faculté de Pharmacie, 13385 Marseille CEDEX 05, FranceAix Marseille Univ, CNRS, ICR UMR 7273, Equipe Pharmaco-Chimie Radicalaire, Faculté de Pharmacie, 13385 Marseille CEDEX 05, FranceAix Marseille Univ, CNRS, ICR UMR 7273, Equipe Pharmaco-Chimie Radicalaire, Faculté de Pharmacie, 13385 Marseille CEDEX 05, FranceRecent progress in reducing malaria cases and ensuing deaths is threatened by factors like mutations that induce resistance to artemisinin derivatives. Multiple drugs are currently in clinical trials for malaria treatment, including some with novel mechanisms of action. One of these, MMV390048, is a plasmodial kinase inhibitor. This review lists the recently developed molecules which target plasmodial kinases. A systematic review of the literature was performed using CAPLUS and MEDLINE databases from 2005 to 2020. It covers a total of 60 articles and describes about one hundred compounds targeting 22 plasmodial kinases. This work highlights the strong potential of compounds targeting plasmodial kinases for future drug therapies. However, the majority of the <i>Plasmodium</i> kinome remains to be explored.https://www.mdpi.com/1420-3049/25/24/5949kinase inhibitor<i>Plasmodium</i>malariaSARmedicinal chemistry |
| spellingShingle | Romain Mustière Patrice Vanelle Nicolas Primas Plasmodial Kinase Inhibitors Targeting Malaria: Recent Developments Molecules kinase inhibitor <i>Plasmodium</i> malaria SAR medicinal chemistry |
| title | Plasmodial Kinase Inhibitors Targeting Malaria: Recent Developments |
| title_full | Plasmodial Kinase Inhibitors Targeting Malaria: Recent Developments |
| title_fullStr | Plasmodial Kinase Inhibitors Targeting Malaria: Recent Developments |
| title_full_unstemmed | Plasmodial Kinase Inhibitors Targeting Malaria: Recent Developments |
| title_short | Plasmodial Kinase Inhibitors Targeting Malaria: Recent Developments |
| title_sort | plasmodial kinase inhibitors targeting malaria recent developments |
| topic | kinase inhibitor <i>Plasmodium</i> malaria SAR medicinal chemistry |
| url | https://www.mdpi.com/1420-3049/25/24/5949 |
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