Longitudinal visual field archetypal analysis of optic neuritis treated in a clinical setting
Background/aims We previously used archetypal analysis (AA) to create a model that quantified patterns (archetypes (ATs)) of visual field (VF) loss that can predict recovery and reveal residual VF deficits from eyes in the Optic Neuritis Treatment Trial (ONTT). We hypothesised that AA could produce...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2022-11-01
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| Series: | BMJ Open Ophthalmology |
| Online Access: | https://bmjophth.bmj.com/content/7/1/e001136.full |
| _version_ | 1811220169148596224 |
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| author | Mark J Kupersmith Louis R Pasquale Randy Kardon Tobias Elze Joseph Branco Jui-Kai Wang Mona K Garvin |
| author_facet | Mark J Kupersmith Louis R Pasquale Randy Kardon Tobias Elze Joseph Branco Jui-Kai Wang Mona K Garvin |
| author_sort | Mark J Kupersmith |
| collection | DOAJ |
| description | Background/aims We previously used archetypal analysis (AA) to create a model that quantified patterns (archetypes (ATs)) of visual field (VF) loss that can predict recovery and reveal residual VF deficits from eyes in the Optic Neuritis Treatment Trial (ONTT). We hypothesised that AA could produce similar results for ON VFs collected in clinical practice.Methods We applied AA to a retrospective data set of 486 VFs collected in 1 neuro-ophthalmology service from 141 eyes with acute ON and typical VF defects, to create a clinic-derived AT model. We also used the ONTT-derived AT model to analyse this new dataset. We compared the findings of both models by decomposing VFs into component ATs of varying per cent weight (PW), correlating presentation AT PW with mean deviation (MD) at final visits for each eye and identifying residual deficits in VFs considered normal.Results Both models, each with 16 ATs, decomposed each presentation VF into 0–6 abnormal ATs representative of known patterns of ON-related VF loss. AT1, the normal pattern in both models, correlated strongly with MD for VFs collected at presentation (r=0.82; p<0.001) and the final visit (r=0.81, p<0.001). The presentation AT1 PW was associated with improvement in MD over time. 67% of VFs considered ‘normal’ at final visit had 1.2±0.4 abnormal ATs, and both models revealed similar patterns of regional VF loss.Conclusions AA is a quantitative method to measure change and outcome of ON VFs. Presentation AT features are associated with MD at final visit. AA identifies residual VF deficits not otherwise indicated by MD. |
| first_indexed | 2024-04-12T07:36:57Z |
| format | Article |
| id | doaj.art-a4d7a61a7a614ecba7fd6bfc58544446 |
| institution | Directory Open Access Journal |
| issn | 2397-3269 |
| language | English |
| last_indexed | 2024-04-12T07:36:57Z |
| publishDate | 2022-11-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open Ophthalmology |
| spelling | doaj.art-a4d7a61a7a614ecba7fd6bfc585444462022-12-22T03:41:54ZengBMJ Publishing GroupBMJ Open Ophthalmology2397-32692022-11-017110.1136/bmjophth-2022-001136Longitudinal visual field archetypal analysis of optic neuritis treated in a clinical settingMark J Kupersmith0Louis R Pasquale1Randy Kardon2Tobias Elze3Joseph Branco4Jui-Kai Wang5Mona K Garvin65 New York Eye and Ear Infirmary and Icahn School of Medicine at Mount Sinai, New York, New York, USAOphthalmology, Icahn School of Medicine at Mount Sinai, New York, New York, USA1 Department of Ophthalmology and Visual Sciences, University of Iowa Hospitals & Clinics, Iowa City, Iowa, USASchepens Eye Research Institute of Massachusetts Eye and Ear, Boston, MA, USANew York Medical College, Valhalla, New York, USAOphthalmology, University of Iowa Hospitals and Clinics Pathology, Iowa City, Iowa, USABioengineering, University of Iowa Hospitals and Clinics Pathology, Iowa City, Iowa, USABackground/aims We previously used archetypal analysis (AA) to create a model that quantified patterns (archetypes (ATs)) of visual field (VF) loss that can predict recovery and reveal residual VF deficits from eyes in the Optic Neuritis Treatment Trial (ONTT). We hypothesised that AA could produce similar results for ON VFs collected in clinical practice.Methods We applied AA to a retrospective data set of 486 VFs collected in 1 neuro-ophthalmology service from 141 eyes with acute ON and typical VF defects, to create a clinic-derived AT model. We also used the ONTT-derived AT model to analyse this new dataset. We compared the findings of both models by decomposing VFs into component ATs of varying per cent weight (PW), correlating presentation AT PW with mean deviation (MD) at final visits for each eye and identifying residual deficits in VFs considered normal.Results Both models, each with 16 ATs, decomposed each presentation VF into 0–6 abnormal ATs representative of known patterns of ON-related VF loss. AT1, the normal pattern in both models, correlated strongly with MD for VFs collected at presentation (r=0.82; p<0.001) and the final visit (r=0.81, p<0.001). The presentation AT1 PW was associated with improvement in MD over time. 67% of VFs considered ‘normal’ at final visit had 1.2±0.4 abnormal ATs, and both models revealed similar patterns of regional VF loss.Conclusions AA is a quantitative method to measure change and outcome of ON VFs. Presentation AT features are associated with MD at final visit. AA identifies residual VF deficits not otherwise indicated by MD.https://bmjophth.bmj.com/content/7/1/e001136.full |
| spellingShingle | Mark J Kupersmith Louis R Pasquale Randy Kardon Tobias Elze Joseph Branco Jui-Kai Wang Mona K Garvin Longitudinal visual field archetypal analysis of optic neuritis treated in a clinical setting BMJ Open Ophthalmology |
| title | Longitudinal visual field archetypal analysis of optic neuritis treated in a clinical setting |
| title_full | Longitudinal visual field archetypal analysis of optic neuritis treated in a clinical setting |
| title_fullStr | Longitudinal visual field archetypal analysis of optic neuritis treated in a clinical setting |
| title_full_unstemmed | Longitudinal visual field archetypal analysis of optic neuritis treated in a clinical setting |
| title_short | Longitudinal visual field archetypal analysis of optic neuritis treated in a clinical setting |
| title_sort | longitudinal visual field archetypal analysis of optic neuritis treated in a clinical setting |
| url | https://bmjophth.bmj.com/content/7/1/e001136.full |
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