Association of maternal pre-pregnancy body mass index with birth weight and preterm birth among singletons conceived after frozen-thawed embryo transfer
Abstract Background To explore the effect of pre-pregnancy body mass index (BMI) on neonatal outcomes among singletons born after frozen embryo transfer (FET). Methods This large retrospective cohort study included 18,683 singleton infants born after FET during the period from Jan 1, 2007 to Dec 31,...
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| Format: | Article |
| Language: | English |
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BMC
2022-06-01
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| Series: | Reproductive Biology and Endocrinology |
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| Online Access: | https://doi.org/10.1186/s12958-022-00957-8 |
| _version_ | 1811247969023819776 |
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| author | Jiaying Lin Haiyan Guo Bian Wang Qianqian Zhu |
| author_facet | Jiaying Lin Haiyan Guo Bian Wang Qianqian Zhu |
| author_sort | Jiaying Lin |
| collection | DOAJ |
| description | Abstract Background To explore the effect of pre-pregnancy body mass index (BMI) on neonatal outcomes among singletons born after frozen embryo transfer (FET). Methods This large retrospective cohort study included 18,683 singleton infants born after FET during the period from Jan 1, 2007 to Dec 31, 2019. The main outcomes were large for gestational age (LGA) and preterm birth. Logistic regression models with generalized estimating equations for clustering by patients to estimate odds ratios of LGA and preterm birth. Results Overweight was positively associated with LGA overall (adjusted OR 1.78 [95%CI 1.60-1.98]), and this association was consistent across age categories. The underweight was inversely associated with LGA among mothers younger than 35 years (adjusted OR 0.49 [95%CI 0.39-0.62] among mothers younger than 30 years; adjusted OR 0.47 [95%CI 0.37-0.60] among mothers aged 30-34 years), but this association was no significant among mothers 35 years or older. Overweight was positively and significantly associated with preterm birth overall (adjusted OR 1.52 [95%CI 1.30-1.77]) and consistently across age categories. The underweight mothers younger than 30 years had a decreased risk of preterm birth (adjusted OR 0.70 [95%CI 0.51-0.97]), but the underweight was no significantly associated with preterm birth among women aged 30 years of older. Conclusions The risks of LGA and preterm birth were increased in singletons born to overweight mothers, regardless of the maternal age. Underweight decreased the risk of LGA and preterm birth for younger mothers. These findings are important for providing preconceptional counseling to specifically targeted women at high risk of LGA and preterm birth. |
| first_indexed | 2024-04-12T15:18:41Z |
| format | Article |
| id | doaj.art-a4d7fe2314664795b9b08e19971caa1c |
| institution | Directory Open Access Journal |
| issn | 1477-7827 |
| language | English |
| last_indexed | 2024-04-12T15:18:41Z |
| publishDate | 2022-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Reproductive Biology and Endocrinology |
| spelling | doaj.art-a4d7fe2314664795b9b08e19971caa1c2022-12-22T03:27:32ZengBMCReproductive Biology and Endocrinology1477-78272022-06-0120111110.1186/s12958-022-00957-8Association of maternal pre-pregnancy body mass index with birth weight and preterm birth among singletons conceived after frozen-thawed embryo transferJiaying Lin0Haiyan Guo1Bian Wang2Qianqian Zhu3Department of Assisted Reproduction, Shanghai Ninth People’s Hospital affiliated to JiaoTong University School of MedicineDepartment of Assisted Reproduction, Shanghai Ninth People’s Hospital affiliated to JiaoTong University School of MedicineDepartment of Assisted Reproduction, Shanghai Ninth People’s Hospital affiliated to JiaoTong University School of MedicineDepartment of Assisted Reproduction, Shanghai Ninth People’s Hospital affiliated to JiaoTong University School of MedicineAbstract Background To explore the effect of pre-pregnancy body mass index (BMI) on neonatal outcomes among singletons born after frozen embryo transfer (FET). Methods This large retrospective cohort study included 18,683 singleton infants born after FET during the period from Jan 1, 2007 to Dec 31, 2019. The main outcomes were large for gestational age (LGA) and preterm birth. Logistic regression models with generalized estimating equations for clustering by patients to estimate odds ratios of LGA and preterm birth. Results Overweight was positively associated with LGA overall (adjusted OR 1.78 [95%CI 1.60-1.98]), and this association was consistent across age categories. The underweight was inversely associated with LGA among mothers younger than 35 years (adjusted OR 0.49 [95%CI 0.39-0.62] among mothers younger than 30 years; adjusted OR 0.47 [95%CI 0.37-0.60] among mothers aged 30-34 years), but this association was no significant among mothers 35 years or older. Overweight was positively and significantly associated with preterm birth overall (adjusted OR 1.52 [95%CI 1.30-1.77]) and consistently across age categories. The underweight mothers younger than 30 years had a decreased risk of preterm birth (adjusted OR 0.70 [95%CI 0.51-0.97]), but the underweight was no significantly associated with preterm birth among women aged 30 years of older. Conclusions The risks of LGA and preterm birth were increased in singletons born to overweight mothers, regardless of the maternal age. Underweight decreased the risk of LGA and preterm birth for younger mothers. These findings are important for providing preconceptional counseling to specifically targeted women at high risk of LGA and preterm birth.https://doi.org/10.1186/s12958-022-00957-8Body mass indexLarge for gestational agePreterm birthFrozen embryo transfer |
| spellingShingle | Jiaying Lin Haiyan Guo Bian Wang Qianqian Zhu Association of maternal pre-pregnancy body mass index with birth weight and preterm birth among singletons conceived after frozen-thawed embryo transfer Reproductive Biology and Endocrinology Body mass index Large for gestational age Preterm birth Frozen embryo transfer |
| title | Association of maternal pre-pregnancy body mass index with birth weight and preterm birth among singletons conceived after frozen-thawed embryo transfer |
| title_full | Association of maternal pre-pregnancy body mass index with birth weight and preterm birth among singletons conceived after frozen-thawed embryo transfer |
| title_fullStr | Association of maternal pre-pregnancy body mass index with birth weight and preterm birth among singletons conceived after frozen-thawed embryo transfer |
| title_full_unstemmed | Association of maternal pre-pregnancy body mass index with birth weight and preterm birth among singletons conceived after frozen-thawed embryo transfer |
| title_short | Association of maternal pre-pregnancy body mass index with birth weight and preterm birth among singletons conceived after frozen-thawed embryo transfer |
| title_sort | association of maternal pre pregnancy body mass index with birth weight and preterm birth among singletons conceived after frozen thawed embryo transfer |
| topic | Body mass index Large for gestational age Preterm birth Frozen embryo transfer |
| url | https://doi.org/10.1186/s12958-022-00957-8 |
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