The prevalence, metabolic disturbances and clinical correlates of recent suicide attempts in Chinese inpatients with major depressive disorder
Abstract Background Metabolic disturbances have been correlated with suicidality, but little is known about the association between suicide risk and metabolic disturbances among individuals with depression. This study was to evaluate the prevalence and clinical correlations, especially cardio-metabo...
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| Format: | Article |
| Language: | English |
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BMC
2019-05-01
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| Series: | BMC Psychiatry |
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| Online Access: | http://link.springer.com/article/10.1186/s12888-019-2131-6 |
| _version_ | 1811294937104252928 |
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| author | Yue-Jiao Ma Dong-Fang Wang Ming Yuan Xiao-Jie Zhang Jiang Long Shu-Bao Chen Qiu-Xia Wu Xu-Yi Wang Marguerite Patel Christopher D. Verrico Tie-Qiao Liu Xiang-Yang Zhang |
| author_facet | Yue-Jiao Ma Dong-Fang Wang Ming Yuan Xiao-Jie Zhang Jiang Long Shu-Bao Chen Qiu-Xia Wu Xu-Yi Wang Marguerite Patel Christopher D. Verrico Tie-Qiao Liu Xiang-Yang Zhang |
| author_sort | Yue-Jiao Ma |
| collection | DOAJ |
| description | Abstract Background Metabolic disturbances have been correlated with suicidality, but little is known about the association between suicide risk and metabolic disturbances among individuals with depression. This study was to evaluate the prevalence and clinical correlations, especially cardio-metabolic associated factors of recent suicide attempts in Chinese patients with major depressive disorder (MDD). Methods A total of 288 MDD inpatients were recruited. Their clinical and demographic data together with plasma glucose, lipid and thyroid function parameters were collected. Self-Rating Depression Scale (SDS), Self-Rating Anxiety Scale (SAS) and Eysenck Personality Questionnaire (EPQ) were rated for most of the patients. Results Of these MDD inpatients, 20.14% had attempted suicide during the past 1 month. Compared to those who had not attempted suicide, the suicide attempters had a significantly longer duration of illness, lower low-density lipoprotein (LDL) cholesterol, lower total cholesterol, and more psychotic symptoms. However, all these significant results did not survive after the bonferroni correction (all p > 0.05). A logistic regression analysis indicated that suicide attempts were associated with the lower total cholesterol and more psychotic symptoms. Conclusions Our findings support the hypothesis of the association of low plasma cholesterol level and recent suicidal attempts in patients with MDD. |
| first_indexed | 2024-04-13T05:25:59Z |
| format | Article |
| id | doaj.art-a4db2b9d83f1489291a9d52762a80fff |
| institution | Directory Open Access Journal |
| issn | 1471-244X |
| language | English |
| last_indexed | 2024-04-13T05:25:59Z |
| publishDate | 2019-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Psychiatry |
| spelling | doaj.art-a4db2b9d83f1489291a9d52762a80fff2022-12-22T03:00:36ZengBMCBMC Psychiatry1471-244X2019-05-011911710.1186/s12888-019-2131-6The prevalence, metabolic disturbances and clinical correlates of recent suicide attempts in Chinese inpatients with major depressive disorderYue-Jiao Ma0Dong-Fang Wang1Ming Yuan2Xiao-Jie Zhang3Jiang Long4Shu-Bao Chen5Qiu-Xia Wu6Xu-Yi Wang7Marguerite Patel8Christopher D. Verrico9Tie-Qiao Liu10Xiang-Yang Zhang11Department of Psychiatry, The Second Xiangya Hospital, Central South University, The China National Clinical Research Center for Mental Health Disorders, Chinese National Technology Institute of Psychiatry, Key Laboratory of Psychiatry and Mental Health of Hunan ProvincePsychosomatic Health Institute of the Third Xiangya Hospital, Central South UniversityDepartment of Psychiatry, The Second Xiangya Hospital, Central South University, The China National Clinical Research Center for Mental Health Disorders, Chinese National Technology Institute of Psychiatry, Key Laboratory of Psychiatry and Mental Health of Hunan ProvinceDepartment of Psychiatry, The Second Xiangya Hospital, Central South University, The China National Clinical Research Center for Mental Health Disorders, Chinese National Technology Institute of Psychiatry, Key Laboratory of Psychiatry and Mental Health of Hunan ProvinceDepartment of Psychiatry, The Second Xiangya Hospital, Central South University, The China National Clinical Research Center for Mental Health Disorders, Chinese National Technology Institute of Psychiatry, Key Laboratory of Psychiatry and Mental Health of Hunan ProvinceDepartment of Psychiatry, The Second Xiangya Hospital, Central South University, The China National Clinical Research Center for Mental Health Disorders, Chinese National Technology Institute of Psychiatry, Key Laboratory of Psychiatry and Mental Health of Hunan ProvinceDepartment of Psychiatry, The Second Xiangya Hospital, Central South University, The China National Clinical Research Center for Mental Health Disorders, Chinese National Technology Institute of Psychiatry, Key Laboratory of Psychiatry and Mental Health of Hunan ProvinceDepartment of Psychiatry, The Second Xiangya Hospital, Central South University, The China National Clinical Research Center for Mental Health Disorders, Chinese National Technology Institute of Psychiatry, Key Laboratory of Psychiatry and Mental Health of Hunan ProvinceDepartment of Psychiatry and Behavioral Sciences, Baylor College of MedicineDepartment of Psychiatry and Behavioral Sciences, Baylor College of MedicineDepartment of Psychiatry, The Second Xiangya Hospital, Central South University, The China National Clinical Research Center for Mental Health Disorders, Chinese National Technology Institute of Psychiatry, Key Laboratory of Psychiatry and Mental Health of Hunan ProvinceInstitute of Psychology, Chinese Academy of SciencesAbstract Background Metabolic disturbances have been correlated with suicidality, but little is known about the association between suicide risk and metabolic disturbances among individuals with depression. This study was to evaluate the prevalence and clinical correlations, especially cardio-metabolic associated factors of recent suicide attempts in Chinese patients with major depressive disorder (MDD). Methods A total of 288 MDD inpatients were recruited. Their clinical and demographic data together with plasma glucose, lipid and thyroid function parameters were collected. Self-Rating Depression Scale (SDS), Self-Rating Anxiety Scale (SAS) and Eysenck Personality Questionnaire (EPQ) were rated for most of the patients. Results Of these MDD inpatients, 20.14% had attempted suicide during the past 1 month. Compared to those who had not attempted suicide, the suicide attempters had a significantly longer duration of illness, lower low-density lipoprotein (LDL) cholesterol, lower total cholesterol, and more psychotic symptoms. However, all these significant results did not survive after the bonferroni correction (all p > 0.05). A logistic regression analysis indicated that suicide attempts were associated with the lower total cholesterol and more psychotic symptoms. Conclusions Our findings support the hypothesis of the association of low plasma cholesterol level and recent suicidal attempts in patients with MDD.http://link.springer.com/article/10.1186/s12888-019-2131-6DepressionSuicide attemptPrevalenceClinical correlatesMetabolic disturbance |
| spellingShingle | Yue-Jiao Ma Dong-Fang Wang Ming Yuan Xiao-Jie Zhang Jiang Long Shu-Bao Chen Qiu-Xia Wu Xu-Yi Wang Marguerite Patel Christopher D. Verrico Tie-Qiao Liu Xiang-Yang Zhang The prevalence, metabolic disturbances and clinical correlates of recent suicide attempts in Chinese inpatients with major depressive disorder BMC Psychiatry Depression Suicide attempt Prevalence Clinical correlates Metabolic disturbance |
| title | The prevalence, metabolic disturbances and clinical correlates of recent suicide attempts in Chinese inpatients with major depressive disorder |
| title_full | The prevalence, metabolic disturbances and clinical correlates of recent suicide attempts in Chinese inpatients with major depressive disorder |
| title_fullStr | The prevalence, metabolic disturbances and clinical correlates of recent suicide attempts in Chinese inpatients with major depressive disorder |
| title_full_unstemmed | The prevalence, metabolic disturbances and clinical correlates of recent suicide attempts in Chinese inpatients with major depressive disorder |
| title_short | The prevalence, metabolic disturbances and clinical correlates of recent suicide attempts in Chinese inpatients with major depressive disorder |
| title_sort | prevalence metabolic disturbances and clinical correlates of recent suicide attempts in chinese inpatients with major depressive disorder |
| topic | Depression Suicide attempt Prevalence Clinical correlates Metabolic disturbance |
| url | http://link.springer.com/article/10.1186/s12888-019-2131-6 |
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