Clinicopathological profile of colorectal carcinoma in a tertiary care teaching hospital in Pokhara, Nepal
Introduction: Colorectal cancer is the most common malignancy of the gastrointestinal tract. They are common after 50 years of age and present with bleeding per rectum, altered bowel habits, anemia, pain abdomen, and weight loss. The objective of this study was to evaluate the demographic profile, c...
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| Format: | Article |
| Language: | English |
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Gandaki Medical College Teaching Hospital & Research Centre Pvt. Ltd.
2021-07-01
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| Series: | Journal of Gandaki Medical College |
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| Online Access: | https://www.nepjol.info/index.php/JGMCN/article/view/30966 |
| _version_ | 1797449579321360384 |
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| author | Subash Bhattarai Om Bahadur Karki Merina Gyawali Sudeep Regmi |
| author_facet | Subash Bhattarai Om Bahadur Karki Merina Gyawali Sudeep Regmi |
| author_sort | Subash Bhattarai |
| collection | DOAJ |
| description | Introduction: Colorectal cancer is the most common malignancy of the gastrointestinal tract. They are common after 50 years of age and present with bleeding per rectum, altered bowel habits, anemia, pain abdomen, and weight loss. The objective of this study was to evaluate the demographic profile, clinical presentation, colonoscopy and histopathology findings of colorectal cancer.
Methods: A descriptive cross-sectional study was conducted. Cases were studied from the departmental records. Clinical presentation, CT abdomen, colonoscopy, and histopathology findings of colorectal carcinoma were studied. Data entry was done in SPSS version 20.
Results: The mean age of subjects was 56 ± 11.42 years (range of 34 – 80 years) with male predominance (M: F=3:2). Changes in bowel habits (92.3%), chronic abdominal pain (84.6%), generalized weakness (80.7%), rectal bleeding (46.2%), and significant weight loss (42.3%) were the most common presenting symptoms. Rectal carcinoma was the most common (35%) followed by carcinomas of ascending colon (14%) and descending colon (10 %). The most common morphology was proliferative growth (61.5%). All colorectal carcinomas were adenocarcinoma, and the majority was moderately differentiated (51.9%).
Conclusion: Colorectal cancers are seen above 50 years of age and common in males. Changes in bowel habits, chronic abdominal pain, generalized weakness, rectal bleeding, and weight loss are the most common form of presentations. These patients usually present late with advanced disease and unfavorable histopathology. Screening colonoscopy >50 years is strongly recommended. |
| first_indexed | 2024-03-09T14:28:02Z |
| format | Article |
| id | doaj.art-a4de71cfbe15477689650ae18c04c563 |
| institution | Directory Open Access Journal |
| issn | 2070-4240 2070-4259 |
| language | English |
| last_indexed | 2024-03-09T14:28:02Z |
| publishDate | 2021-07-01 |
| publisher | Gandaki Medical College Teaching Hospital & Research Centre Pvt. Ltd. |
| record_format | Article |
| series | Journal of Gandaki Medical College |
| spelling | doaj.art-a4de71cfbe15477689650ae18c04c5632023-11-28T05:02:16ZengGandaki Medical College Teaching Hospital & Research Centre Pvt. Ltd.Journal of Gandaki Medical College2070-42402070-42592021-07-01141141810.3126/jgmcn.v14i1.3096630966Clinicopathological profile of colorectal carcinoma in a tertiary care teaching hospital in Pokhara, NepalSubash Bhattarai0Om Bahadur Karki1Merina Gyawali2Sudeep Regmi3Manipal College of Medical Sciences and Teaching Hospital,Pokhara NepalDepartment of Surgery, Manipal College of Medical Sciences and Teaching Hospital, Pokhara, NepalDepartment of Radio diagnosis and Imaging, Manipal College of Medical Sciences and Teaching Hospital, Pokhara, NepalDepartment of Pathology, Manipal College of Medical Sciences and Teaching Hospital, Pokhara, NepalIntroduction: Colorectal cancer is the most common malignancy of the gastrointestinal tract. They are common after 50 years of age and present with bleeding per rectum, altered bowel habits, anemia, pain abdomen, and weight loss. The objective of this study was to evaluate the demographic profile, clinical presentation, colonoscopy and histopathology findings of colorectal cancer. Methods: A descriptive cross-sectional study was conducted. Cases were studied from the departmental records. Clinical presentation, CT abdomen, colonoscopy, and histopathology findings of colorectal carcinoma were studied. Data entry was done in SPSS version 20. Results: The mean age of subjects was 56 ± 11.42 years (range of 34 – 80 years) with male predominance (M: F=3:2). Changes in bowel habits (92.3%), chronic abdominal pain (84.6%), generalized weakness (80.7%), rectal bleeding (46.2%), and significant weight loss (42.3%) were the most common presenting symptoms. Rectal carcinoma was the most common (35%) followed by carcinomas of ascending colon (14%) and descending colon (10 %). The most common morphology was proliferative growth (61.5%). All colorectal carcinomas were adenocarcinoma, and the majority was moderately differentiated (51.9%). Conclusion: Colorectal cancers are seen above 50 years of age and common in males. Changes in bowel habits, chronic abdominal pain, generalized weakness, rectal bleeding, and weight loss are the most common form of presentations. These patients usually present late with advanced disease and unfavorable histopathology. Screening colonoscopy >50 years is strongly recommended.https://www.nepjol.info/index.php/JGMCN/article/view/30966colorectal carcinomacolonoscopyclinical presentationhistopathology |
| spellingShingle | Subash Bhattarai Om Bahadur Karki Merina Gyawali Sudeep Regmi Clinicopathological profile of colorectal carcinoma in a tertiary care teaching hospital in Pokhara, Nepal Journal of Gandaki Medical College colorectal carcinoma colonoscopy clinical presentation histopathology |
| title | Clinicopathological profile of colorectal carcinoma in a tertiary care teaching hospital in Pokhara, Nepal |
| title_full | Clinicopathological profile of colorectal carcinoma in a tertiary care teaching hospital in Pokhara, Nepal |
| title_fullStr | Clinicopathological profile of colorectal carcinoma in a tertiary care teaching hospital in Pokhara, Nepal |
| title_full_unstemmed | Clinicopathological profile of colorectal carcinoma in a tertiary care teaching hospital in Pokhara, Nepal |
| title_short | Clinicopathological profile of colorectal carcinoma in a tertiary care teaching hospital in Pokhara, Nepal |
| title_sort | clinicopathological profile of colorectal carcinoma in a tertiary care teaching hospital in pokhara nepal |
| topic | colorectal carcinoma colonoscopy clinical presentation histopathology |
| url | https://www.nepjol.info/index.php/JGMCN/article/view/30966 |
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