Neoadjuvant therapy with immune checkpoint blockade, antiangiogenesis, and chemotherapy for locally advanced gastric cancer
Immune checkpoint inhibitors and antiangiogenic agents have shown some activity in patients with late-stage gastric cancer. Here the authors report the results of a phase II trial of neoadjuvant anti-PD1 (camrelizumab), antiangiogenic agent (apatinib), and chemotherapy (S-1 ± Oxaliplatin) in stage T...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-35431-x |
| _version_ | 1797958588525707264 |
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| author | Song Li Wenbin Yu Fei Xie Haitao Luo Zhimin Liu Weiwei Lv Duanbo Shi Dexin Yu Peng Gao Cheng Chen Meng Wei Wenhao Zhou Jiaqian Wang Zhikun Zhao Xin Dai Qian Xu Xue Zhang Miao Huang Kai Huang Jian Wang Jisheng Li Lei Sheng Lian Liu |
| author_facet | Song Li Wenbin Yu Fei Xie Haitao Luo Zhimin Liu Weiwei Lv Duanbo Shi Dexin Yu Peng Gao Cheng Chen Meng Wei Wenhao Zhou Jiaqian Wang Zhikun Zhao Xin Dai Qian Xu Xue Zhang Miao Huang Kai Huang Jian Wang Jisheng Li Lei Sheng Lian Liu |
| author_sort | Song Li |
| collection | DOAJ |
| description | Immune checkpoint inhibitors and antiangiogenic agents have shown some activity in patients with late-stage gastric cancer. Here the authors report the results of a phase II trial of neoadjuvant anti-PD1 (camrelizumab), antiangiogenic agent (apatinib), and chemotherapy (S-1 ± Oxaliplatin) in stage T4a/bN + M0 gastric cancer patients. |
| first_indexed | 2024-04-11T00:22:10Z |
| format | Article |
| id | doaj.art-a4e190d3b92f4b949cc25d4b09eb4a42 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-11T00:22:10Z |
| publishDate | 2023-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-a4e190d3b92f4b949cc25d4b09eb4a422023-01-08T12:15:41ZengNature PortfolioNature Communications2041-17232023-01-0114111610.1038/s41467-022-35431-xNeoadjuvant therapy with immune checkpoint blockade, antiangiogenesis, and chemotherapy for locally advanced gastric cancerSong Li0Wenbin Yu1Fei Xie2Haitao Luo3Zhimin Liu4Weiwei Lv5Duanbo Shi6Dexin Yu7Peng Gao8Cheng Chen9Meng Wei10Wenhao Zhou11Jiaqian Wang12Zhikun Zhao13Xin Dai14Qian Xu15Xue Zhang16Miao Huang17Kai Huang18Jian Wang19Jisheng Li20Lei Sheng21Lian Liu22Department of Medical Oncology, Qilu Hospital, Cheeloo College of Medicine, Shandong UniversityDepartment of General Surgery, Qilu Hospital, Cheeloo College of Medicine, Shandong UniversityDepartment of Pharmacy, Qilu Hospital, Cheeloo College of Medicine, Shandong UniversityShenzhen Yucebio Technology Co., Ltd., ShenzhenDepartment of General Surgery, Zibo Municipal Central Hospital, Binzhou Medical CollegeDepartment of Radiology, Qilu Hospital, Cheeloo College of Medicine, Shandong UniversityDepartment of Pathology, Qilu Hospital, Cheeloo College of Medicine, Shandong UniversityDepartment of Radiology, Qilu Hospital, Cheeloo College of Medicine, Shandong UniversityDepartment of Pathology, Qilu Hospital, Cheeloo College of Medicine, Shandong UniversityDepartment of General Surgery, Qilu Hospital, Cheeloo College of Medicine, Shandong UniversityDepartment of General Surgery, Qilu Hospital, Cheeloo College of Medicine, Shandong UniversityShenzhen Yucebio Technology Co., Ltd., ShenzhenShenzhen Yucebio Technology Co., Ltd., ShenzhenShenzhen Yucebio Technology Co., Ltd., ShenzhenDepartment of Medical Oncology, Shandong Provincial Hospital of Traditional Chinese MedicineDepartment of Medical Oncology, Qilu Hospital, Cheeloo College of Medicine, Shandong UniversityDepartment of Medical Oncology, Qilu Hospital, Cheeloo College of Medicine, Shandong UniversityDepartment of Medical Oncology, Qilu Hospital, Cheeloo College of Medicine, Shandong UniversityDepartment of Medical Oncology, Qilu Hospital, Cheeloo College of Medicine, Shandong UniversityDepartment of Medical Oncology, Qilu Hospital, Cheeloo College of Medicine, Shandong UniversityDepartment of Medical Oncology, Qilu Hospital, Cheeloo College of Medicine, Shandong UniversityDepartment of General Surgery, Qilu Hospital, Cheeloo College of Medicine, Shandong UniversityDepartment of Medical Oncology, Qilu Hospital, Cheeloo College of Medicine, Shandong UniversityImmune checkpoint inhibitors and antiangiogenic agents have shown some activity in patients with late-stage gastric cancer. Here the authors report the results of a phase II trial of neoadjuvant anti-PD1 (camrelizumab), antiangiogenic agent (apatinib), and chemotherapy (S-1 ± Oxaliplatin) in stage T4a/bN + M0 gastric cancer patients.https://doi.org/10.1038/s41467-022-35431-x |
| spellingShingle | Song Li Wenbin Yu Fei Xie Haitao Luo Zhimin Liu Weiwei Lv Duanbo Shi Dexin Yu Peng Gao Cheng Chen Meng Wei Wenhao Zhou Jiaqian Wang Zhikun Zhao Xin Dai Qian Xu Xue Zhang Miao Huang Kai Huang Jian Wang Jisheng Li Lei Sheng Lian Liu Neoadjuvant therapy with immune checkpoint blockade, antiangiogenesis, and chemotherapy for locally advanced gastric cancer Nature Communications |
| title | Neoadjuvant therapy with immune checkpoint blockade, antiangiogenesis, and chemotherapy for locally advanced gastric cancer |
| title_full | Neoadjuvant therapy with immune checkpoint blockade, antiangiogenesis, and chemotherapy for locally advanced gastric cancer |
| title_fullStr | Neoadjuvant therapy with immune checkpoint blockade, antiangiogenesis, and chemotherapy for locally advanced gastric cancer |
| title_full_unstemmed | Neoadjuvant therapy with immune checkpoint blockade, antiangiogenesis, and chemotherapy for locally advanced gastric cancer |
| title_short | Neoadjuvant therapy with immune checkpoint blockade, antiangiogenesis, and chemotherapy for locally advanced gastric cancer |
| title_sort | neoadjuvant therapy with immune checkpoint blockade antiangiogenesis and chemotherapy for locally advanced gastric cancer |
| url | https://doi.org/10.1038/s41467-022-35431-x |
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