Preventive Gabapentin versus Pregabalin to Decrease Postoperative Pain after Lumbar Microdiscectomy: A Randomized Controlled Trial
Study DesignRandomized controlled trial.PurposeThe purpose of this study was to compare pregabalin and gabapentin for mean postoperative visual analog score (VAS) for pain in patients undergoing single-level lumbar microdiscectomy for intervertebral disc prolapse at a tertiary care hospital.Overview...
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| Format: | Article |
| Language: | English |
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Korean Spine Society
2017-02-01
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| Series: | Asian Spine Journal |
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| Online Access: | http://www.asianspinejournal.org/upload/pdf/asj-11-93.pdf |
| _version_ | 1811270316455886848 |
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| author | Mohsin Qadeer Muhammad Waqas Muhammad Jawad Rashid Syed Ather Enam Salman Sharif Ghulam Murtaza |
| author_facet | Mohsin Qadeer Muhammad Waqas Muhammad Jawad Rashid Syed Ather Enam Salman Sharif Ghulam Murtaza |
| author_sort | Mohsin Qadeer |
| collection | DOAJ |
| description | Study DesignRandomized controlled trial.PurposeThe purpose of this study was to compare pregabalin and gabapentin for mean postoperative visual analog score (VAS) for pain in patients undergoing single-level lumbar microdiscectomy for intervertebral disc prolapse at a tertiary care hospital.Overview of LiteraturePregabalin has a superior pharmacokinetic profile and analgesic effect at lower doses than gabapentin; however, analgesic efficacy must be established during the perioperative period after lumbar spine surgery.MethodsThis randomized controlled trial was carried out at our institute from February to October 2011 on 78 patients, with 39 participants in each study group. Patients undergoing lumbar microdiscectomy were randomized to group A (gabapentin) or group B (pregabalin) and started on trial medicines one week before surgery. The VAS for pain was recorded at 24 hours and one week postoperatively.ResultsBoth groups had similar baseline variables, with mean ages of 42 and 39 years in groups A and B, respectively, and a majority of male patients in each group. The mean VAS values for pain at 24 hours for gabapentin vs. pregabalin were comparable (1.97±0.84 vs. 1.6±0.87, respectively; p=0.087) as were the results at one week after surgery (0.27±0.45 vs. 0.3±0.46, respectively; p=0.79). None of the patients required additional analgesia postoperatively. After adjusting for age and sex, the VAS value for group B patients was 0.028 points lower than for group A patients, but this difference was not statistically significant (p=0.817, R2=0.018).ConclusionsPregabalin is equivalent to gabapentin for the relief of postoperative pain at a lower dose in patients undergoing lumbar microdiscectomy. Therefore, other factors, such as dose, frequency, cost, pharmacokinetics, and side effects of these medicines, should be taken into account whenever it is prescribed. |
| first_indexed | 2024-04-12T21:59:12Z |
| format | Article |
| id | doaj.art-a4e229590dcb41a39d0f17f0b9a3e216 |
| institution | Directory Open Access Journal |
| issn | 1976-1902 1976-7846 |
| language | English |
| last_indexed | 2024-04-12T21:59:12Z |
| publishDate | 2017-02-01 |
| publisher | Korean Spine Society |
| record_format | Article |
| series | Asian Spine Journal |
| spelling | doaj.art-a4e229590dcb41a39d0f17f0b9a3e2162022-12-22T03:15:11ZengKorean Spine SocietyAsian Spine Journal1976-19021976-78462017-02-01111939810.4184/asj.2017.11.1.93310Preventive Gabapentin versus Pregabalin to Decrease Postoperative Pain after Lumbar Microdiscectomy: A Randomized Controlled TrialMohsin Qadeer0Muhammad Waqas1Muhammad Jawad Rashid2Syed Ather Enam3Salman Sharif4Ghulam Murtaza5The Aga Khan University Hospital, Karachi, Pakistan.The Aga Khan University Hospital, Karachi, Pakistan.Baqai Medical College, Karachi, Pakistan.The Aga Khan University Hospital, Karachi, Pakistan.Liaquat National Hospital, Karachi, Pakistan.Patel Hospital, Karachi, Pakistan.Study DesignRandomized controlled trial.PurposeThe purpose of this study was to compare pregabalin and gabapentin for mean postoperative visual analog score (VAS) for pain in patients undergoing single-level lumbar microdiscectomy for intervertebral disc prolapse at a tertiary care hospital.Overview of LiteraturePregabalin has a superior pharmacokinetic profile and analgesic effect at lower doses than gabapentin; however, analgesic efficacy must be established during the perioperative period after lumbar spine surgery.MethodsThis randomized controlled trial was carried out at our institute from February to October 2011 on 78 patients, with 39 participants in each study group. Patients undergoing lumbar microdiscectomy were randomized to group A (gabapentin) or group B (pregabalin) and started on trial medicines one week before surgery. The VAS for pain was recorded at 24 hours and one week postoperatively.ResultsBoth groups had similar baseline variables, with mean ages of 42 and 39 years in groups A and B, respectively, and a majority of male patients in each group. The mean VAS values for pain at 24 hours for gabapentin vs. pregabalin were comparable (1.97±0.84 vs. 1.6±0.87, respectively; p=0.087) as were the results at one week after surgery (0.27±0.45 vs. 0.3±0.46, respectively; p=0.79). None of the patients required additional analgesia postoperatively. After adjusting for age and sex, the VAS value for group B patients was 0.028 points lower than for group A patients, but this difference was not statistically significant (p=0.817, R2=0.018).ConclusionsPregabalin is equivalent to gabapentin for the relief of postoperative pain at a lower dose in patients undergoing lumbar microdiscectomy. Therefore, other factors, such as dose, frequency, cost, pharmacokinetics, and side effects of these medicines, should be taken into account whenever it is prescribed.http://www.asianspinejournal.org/upload/pdf/asj-11-93.pdfIntervertebral disc displacementLumbar vertebraePregabalinGabapentinPostoperative pain |
| spellingShingle | Mohsin Qadeer Muhammad Waqas Muhammad Jawad Rashid Syed Ather Enam Salman Sharif Ghulam Murtaza Preventive Gabapentin versus Pregabalin to Decrease Postoperative Pain after Lumbar Microdiscectomy: A Randomized Controlled Trial Asian Spine Journal Intervertebral disc displacement Lumbar vertebrae Pregabalin Gabapentin Postoperative pain |
| title | Preventive Gabapentin versus Pregabalin to Decrease Postoperative Pain after Lumbar Microdiscectomy: A Randomized Controlled Trial |
| title_full | Preventive Gabapentin versus Pregabalin to Decrease Postoperative Pain after Lumbar Microdiscectomy: A Randomized Controlled Trial |
| title_fullStr | Preventive Gabapentin versus Pregabalin to Decrease Postoperative Pain after Lumbar Microdiscectomy: A Randomized Controlled Trial |
| title_full_unstemmed | Preventive Gabapentin versus Pregabalin to Decrease Postoperative Pain after Lumbar Microdiscectomy: A Randomized Controlled Trial |
| title_short | Preventive Gabapentin versus Pregabalin to Decrease Postoperative Pain after Lumbar Microdiscectomy: A Randomized Controlled Trial |
| title_sort | preventive gabapentin versus pregabalin to decrease postoperative pain after lumbar microdiscectomy a randomized controlled trial |
| topic | Intervertebral disc displacement Lumbar vertebrae Pregabalin Gabapentin Postoperative pain |
| url | http://www.asianspinejournal.org/upload/pdf/asj-11-93.pdf |
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