The Prevalence of Anemia and Hemoglobinopathies in the Hematologic Clinics of the Kermanshah Province, Western Iran
Hemoglobinopathies are the most common single gene disorders worldwide with a considerable frequency in certain area particularly Mediterranean and Middle Eastern countries. Hemoglobinopathies include structural variants of hemoglobin (Hb S, Hb C, HbE,…) and thalassaemias which are inherited defects...
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| Format: | Article |
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Tehran University of Medical Sciences
2014-06-01
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| Series: | International Journal of Hematology-Oncology and Stem Cell Research |
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| Online Access: | https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/422 |
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| author | Mehrdad Payandeh Zohreh Rahimi Mohammad Erfan Zare Atefeh Nasir Kansestani Farzad Gohardehi Amir Hossein Hashemian |
| author_facet | Mehrdad Payandeh Zohreh Rahimi Mohammad Erfan Zare Atefeh Nasir Kansestani Farzad Gohardehi Amir Hossein Hashemian |
| author_sort | Mehrdad Payandeh |
| collection | DOAJ |
| description | Hemoglobinopathies are the most common single gene disorders worldwide with a considerable frequency in certain area particularly Mediterranean and Middle Eastern countries. Hemoglobinopathies include structural variants of hemoglobin (Hb S, Hb C, HbE,…) and thalassaemias which are inherited defects in the globin chains synthesis. The present study was conducted to determine the prevalence of hemoglobinopathies in western Iranian patients. A total of 344 patients (151 males and 193 females) with abnormal CBC and/or hemoglobin electrophoresis were enrolled in the present study. Cellulose acetate gel electrophoresis was performed for all patients and abnormal bands were identified by citrate agar gel electrophoresis and PCR based methods. Iron deficiency anemia (IDA) was present in 156 (45.3%) individuals. Thirty four (9.8%) patients had both iron deficiency anemia and α-thalassemia trait trait, 41(11.9%) patients were with both iron deficiency anemia and minor β-thalassemia. There were 31(9%) patients with α-thalassemia trait and 5 (2.2%) patients with Hb H disease. Fifty six (16.2%) patients had minor β-thalassemia. Also, there were 10 (2.9%) individuals homozygous for hemoglobin D-Punjab and one patient with hemoglobin G (0.3%). There was one sample with hemoglobin C. Further, we found 3 patients (0.9%) with sickle cell trait and more 3 patients (0.8%) with S/ β +-thalassemia. Our results indicated that the most frequent cause of hypochromic and/or microcytic anemia in our population was IDA and the minor β-thalassemia was the second cause that needs to more attention in screening programs. |
| first_indexed | 2024-03-12T08:57:58Z |
| format | Article |
| id | doaj.art-a4e24afa5c9f43a8bb9175888333b1ec |
| institution | Directory Open Access Journal |
| issn | 2008-2207 |
| language | English |
| last_indexed | 2024-03-12T08:57:58Z |
| publishDate | 2014-06-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | International Journal of Hematology-Oncology and Stem Cell Research |
| spelling | doaj.art-a4e24afa5c9f43a8bb9175888333b1ec2023-09-02T15:53:06ZengTehran University of Medical SciencesInternational Journal of Hematology-Oncology and Stem Cell Research2008-22072014-06-0182408The Prevalence of Anemia and Hemoglobinopathies in the Hematologic Clinics of the Kermanshah Province, Western IranMehrdad Payandeh0Zohreh Rahimi1Mohammad Erfan Zare2Atefeh Nasir Kansestani3Farzad Gohardehi4Amir Hossein Hashemian5Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran. AND Nosocomial Infection Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran. AND Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran.Student Research Committee, Mazandaran University of Medical Sciences, Mazandaran, Iran.Department of Biostatistics, Faculty of Public Health, Kermanshah University of Medical Science, Kermanshah, Iran.Hemoglobinopathies are the most common single gene disorders worldwide with a considerable frequency in certain area particularly Mediterranean and Middle Eastern countries. Hemoglobinopathies include structural variants of hemoglobin (Hb S, Hb C, HbE,…) and thalassaemias which are inherited defects in the globin chains synthesis. The present study was conducted to determine the prevalence of hemoglobinopathies in western Iranian patients. A total of 344 patients (151 males and 193 females) with abnormal CBC and/or hemoglobin electrophoresis were enrolled in the present study. Cellulose acetate gel electrophoresis was performed for all patients and abnormal bands were identified by citrate agar gel electrophoresis and PCR based methods. Iron deficiency anemia (IDA) was present in 156 (45.3%) individuals. Thirty four (9.8%) patients had both iron deficiency anemia and α-thalassemia trait trait, 41(11.9%) patients were with both iron deficiency anemia and minor β-thalassemia. There were 31(9%) patients with α-thalassemia trait and 5 (2.2%) patients with Hb H disease. Fifty six (16.2%) patients had minor β-thalassemia. Also, there were 10 (2.9%) individuals homozygous for hemoglobin D-Punjab and one patient with hemoglobin G (0.3%). There was one sample with hemoglobin C. Further, we found 3 patients (0.9%) with sickle cell trait and more 3 patients (0.8%) with S/ β +-thalassemia. Our results indicated that the most frequent cause of hypochromic and/or microcytic anemia in our population was IDA and the minor β-thalassemia was the second cause that needs to more attention in screening programs.https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/422AnemiaHemoglobinopathiesIron deficiency anemiaα-thalassemiaβ-thalassemia |
| spellingShingle | Mehrdad Payandeh Zohreh Rahimi Mohammad Erfan Zare Atefeh Nasir Kansestani Farzad Gohardehi Amir Hossein Hashemian The Prevalence of Anemia and Hemoglobinopathies in the Hematologic Clinics of the Kermanshah Province, Western Iran International Journal of Hematology-Oncology and Stem Cell Research Anemia Hemoglobinopathies Iron deficiency anemia α-thalassemia β-thalassemia |
| title | The Prevalence of Anemia and Hemoglobinopathies in the Hematologic Clinics of the Kermanshah Province, Western Iran |
| title_full | The Prevalence of Anemia and Hemoglobinopathies in the Hematologic Clinics of the Kermanshah Province, Western Iran |
| title_fullStr | The Prevalence of Anemia and Hemoglobinopathies in the Hematologic Clinics of the Kermanshah Province, Western Iran |
| title_full_unstemmed | The Prevalence of Anemia and Hemoglobinopathies in the Hematologic Clinics of the Kermanshah Province, Western Iran |
| title_short | The Prevalence of Anemia and Hemoglobinopathies in the Hematologic Clinics of the Kermanshah Province, Western Iran |
| title_sort | prevalence of anemia and hemoglobinopathies in the hematologic clinics of the kermanshah province western iran |
| topic | Anemia Hemoglobinopathies Iron deficiency anemia α-thalassemia β-thalassemia |
| url | https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/422 |
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