Local forms of diclofenac in the treatment of acute and chronic pain
According to modern ideas, pain is a multidisciplinary problem with serious medical and socio-economic importance. The most common pain occurs in various structures of the musculoskeletal system. It is noted that the universal mechanism of acute and chronic pain is inflammation, which requires thera...
| Main Authors: | , , |
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| Format: | Article |
| Language: | Russian |
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Remedium Group LLC
2019-12-01
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| Series: | Медицинский совет |
| Subjects: | |
| Online Access: | https://www.med-sovet.pro/jour/article/view/4992 |
| _version_ | 1827961642229432320 |
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| author | G. R. Imametdinova E. V. Igolkina N. V. Chichasova |
| author_facet | G. R. Imametdinova E. V. Igolkina N. V. Chichasova |
| author_sort | G. R. Imametdinova |
| collection | DOAJ |
| description | According to modern ideas, pain is a multidisciplinary problem with serious medical and socio-economic importance. The most common pain occurs in various structures of the musculoskeletal system. It is noted that the universal mechanism of acute and chronic pain is inflammation, which requires therapy with nonsteroidal anti-inflammatory drugs (NSAIDs). Data on the effectiveness and good tolerability of local NSAIDs are presented. The latest recommendations of the international Committee ESCEO 2019 on the management of patients with osteoarthritis (OA), which confirms the effectiveness and safety of local forms of NSAIDs, in connection with which, ESCEO recommends their use in elderly patients, in patients with comorbid conditions and at high risk of adverse reactions. It is also envisaged to use these drugs for the treatment of OA before the appointment of systemic NSAIDs. The results of randomized clinical trials (RCTS) and meta-analyses confirming clinical efficacy and safety in the treatment of acute and chronic pain by one of the representatives of local NSAIDs-diclofenac sodium gel are presented. Diclofenac sodium gel has been shown to be more effective than placebo in the treatment of acute and chronic pain. Good tolerability of the drug was observed in patients in different age groups, including patients older than 65 years, and in patients with comorbid conditions. The results obtained indicate the effectiveness and good tolerability of diclofenac sodium gel, including long-term, and allow the drug to be widely used as symptomatic therapy for the treatment of acute and chronic pain, including in elderly patients and patients with comorbid conditions. |
| first_indexed | 2024-04-09T16:29:53Z |
| format | Article |
| id | doaj.art-a4e603e50d0f4c35aa26906aee3e54e7 |
| institution | Directory Open Access Journal |
| issn | 2079-701X 2658-5790 |
| language | Russian |
| last_indexed | 2024-04-09T16:29:53Z |
| publishDate | 2019-12-01 |
| publisher | Remedium Group LLC |
| record_format | Article |
| series | Медицинский совет |
| spelling | doaj.art-a4e603e50d0f4c35aa26906aee3e54e72023-04-23T06:57:10ZrusRemedium Group LLCМедицинский совет2079-701X2658-57902019-12-0101810410810.21518/2079-701X-2019-18-104-1084530Local forms of diclofenac in the treatment of acute and chronic painG. R. Imametdinova0E. V. Igolkina1N. V. Chichasova2Federal State Budgetary Institution «Research Institute of Rheumatology named after V.A. Nasonova»Federal State Budgetary Institution «Research Institute of Rheumatology named after V.A. Nasonova»Federal State Budgetary Institution «Research Institute of Rheumatology named after V.A. Nasonova»According to modern ideas, pain is a multidisciplinary problem with serious medical and socio-economic importance. The most common pain occurs in various structures of the musculoskeletal system. It is noted that the universal mechanism of acute and chronic pain is inflammation, which requires therapy with nonsteroidal anti-inflammatory drugs (NSAIDs). Data on the effectiveness and good tolerability of local NSAIDs are presented. The latest recommendations of the international Committee ESCEO 2019 on the management of patients with osteoarthritis (OA), which confirms the effectiveness and safety of local forms of NSAIDs, in connection with which, ESCEO recommends their use in elderly patients, in patients with comorbid conditions and at high risk of adverse reactions. It is also envisaged to use these drugs for the treatment of OA before the appointment of systemic NSAIDs. The results of randomized clinical trials (RCTS) and meta-analyses confirming clinical efficacy and safety in the treatment of acute and chronic pain by one of the representatives of local NSAIDs-diclofenac sodium gel are presented. Diclofenac sodium gel has been shown to be more effective than placebo in the treatment of acute and chronic pain. Good tolerability of the drug was observed in patients in different age groups, including patients older than 65 years, and in patients with comorbid conditions. The results obtained indicate the effectiveness and good tolerability of diclofenac sodium gel, including long-term, and allow the drug to be widely used as symptomatic therapy for the treatment of acute and chronic pain, including in elderly patients and patients with comorbid conditions.https://www.med-sovet.pro/jour/article/view/4992local forms of nonsteroidal anti-inflammatory drugsacute painchronic paindiclofenacdiclofenac sodium gel |
| spellingShingle | G. R. Imametdinova E. V. Igolkina N. V. Chichasova Local forms of diclofenac in the treatment of acute and chronic pain Медицинский совет local forms of nonsteroidal anti-inflammatory drugs acute pain chronic pain diclofenac diclofenac sodium gel |
| title | Local forms of diclofenac in the treatment of acute and chronic pain |
| title_full | Local forms of diclofenac in the treatment of acute and chronic pain |
| title_fullStr | Local forms of diclofenac in the treatment of acute and chronic pain |
| title_full_unstemmed | Local forms of diclofenac in the treatment of acute and chronic pain |
| title_short | Local forms of diclofenac in the treatment of acute and chronic pain |
| title_sort | local forms of diclofenac in the treatment of acute and chronic pain |
| topic | local forms of nonsteroidal anti-inflammatory drugs acute pain chronic pain diclofenac diclofenac sodium gel |
| url | https://www.med-sovet.pro/jour/article/view/4992 |
| work_keys_str_mv | AT grimametdinova localformsofdiclofenacinthetreatmentofacuteandchronicpain AT evigolkina localformsofdiclofenacinthetreatmentofacuteandchronicpain AT nvchichasova localformsofdiclofenacinthetreatmentofacuteandchronicpain |