From Immunodeficiency to Humanization: The Contribution of Mouse Models to Explore HTLV-1 Leukemogenesis
The first discovered human retrovirus, Human T-Lymphotropic Virus type 1 (HTLV-1), is responsible for an aggressive form of T cell leukemia/lymphoma. Mouse models recapitulating the leukemogenesis process have been helpful for understanding the mechanisms underlying the pathogenesis of this retrovir...
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| Format: | Article |
| Language: | English |
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MDPI AG
2015-12-01
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| Series: | Viruses |
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| Online Access: | http://www.mdpi.com/1999-4915/7/12/2944 |
| _version_ | 1818960978212028416 |
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| author | Eléonore Pérès Eugénie Bagdassarian Sébastien This Julien Villaudy Dominique Rigal Louis Gazzolo Madeleine Duc Dodon |
| author_facet | Eléonore Pérès Eugénie Bagdassarian Sébastien This Julien Villaudy Dominique Rigal Louis Gazzolo Madeleine Duc Dodon |
| author_sort | Eléonore Pérès |
| collection | DOAJ |
| description | The first discovered human retrovirus, Human T-Lymphotropic Virus type 1 (HTLV-1), is responsible for an aggressive form of T cell leukemia/lymphoma. Mouse models recapitulating the leukemogenesis process have been helpful for understanding the mechanisms underlying the pathogenesis of this retroviral-induced disease. This review will focus on the recent advances in the generation of immunodeficient and human hemato-lymphoid system mice with a particular emphasis on the development of mouse models for HTLV-1-mediated pathogenesis, their present limitations and the challenges yet to be addressed. |
| first_indexed | 2024-12-20T12:06:07Z |
| format | Article |
| id | doaj.art-a4e668963d92413cadf451abd10caf7b |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-12-20T12:06:07Z |
| publishDate | 2015-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-a4e668963d92413cadf451abd10caf7b2022-12-21T19:41:23ZengMDPI AGViruses1999-49152015-12-017126371638610.3390/v7122944v7122944From Immunodeficiency to Humanization: The Contribution of Mouse Models to Explore HTLV-1 LeukemogenesisEléonore Pérès0Eugénie Bagdassarian1Sébastien This2Julien Villaudy3Dominique Rigal4Louis Gazzolo5Madeleine Duc Dodon6Laboratoire de Biologie Moléculaire de la Cellule, Unité Mixte de Recherche 5239, Centre National de la Recherche Scientifique, Ecole Normale Supérieure de Lyon, 69364 Lyon Cedex 7, FranceLaboratoire de Biologie Moléculaire de la Cellule, Unité Mixte de Recherche 5239, Centre National de la Recherche Scientifique, Ecole Normale Supérieure de Lyon, 69364 Lyon Cedex 7, FranceLaboratoire de Biologie Moléculaire de la Cellule, Unité Mixte de Recherche 5239, Centre National de la Recherche Scientifique, Ecole Normale Supérieure de Lyon, 69364 Lyon Cedex 7, FranceAIMM Therapeutics, Meibergdreef 59, 1105 BA Amsterdam Zuidoost, The NetherlandsEtablissement français du sang, 69007 Lyon, FranceLaboratoire de Biologie Moléculaire de la Cellule, Unité Mixte de Recherche 5239, Centre National de la Recherche Scientifique, Ecole Normale Supérieure de Lyon, 69364 Lyon Cedex 7, FranceLaboratoire de Biologie Moléculaire de la Cellule, Unité Mixte de Recherche 5239, Centre National de la Recherche Scientifique, Ecole Normale Supérieure de Lyon, 69364 Lyon Cedex 7, FranceThe first discovered human retrovirus, Human T-Lymphotropic Virus type 1 (HTLV-1), is responsible for an aggressive form of T cell leukemia/lymphoma. Mouse models recapitulating the leukemogenesis process have been helpful for understanding the mechanisms underlying the pathogenesis of this retroviral-induced disease. This review will focus on the recent advances in the generation of immunodeficient and human hemato-lymphoid system mice with a particular emphasis on the development of mouse models for HTLV-1-mediated pathogenesis, their present limitations and the challenges yet to be addressed.http://www.mdpi.com/1999-4915/7/12/2944adult T cell leukemia/lymphomaHTLV-1humanized mouse modelsoncogenesis |
| spellingShingle | Eléonore Pérès Eugénie Bagdassarian Sébastien This Julien Villaudy Dominique Rigal Louis Gazzolo Madeleine Duc Dodon From Immunodeficiency to Humanization: The Contribution of Mouse Models to Explore HTLV-1 Leukemogenesis Viruses adult T cell leukemia/lymphoma HTLV-1 humanized mouse models oncogenesis |
| title | From Immunodeficiency to Humanization: The Contribution of Mouse Models to Explore HTLV-1 Leukemogenesis |
| title_full | From Immunodeficiency to Humanization: The Contribution of Mouse Models to Explore HTLV-1 Leukemogenesis |
| title_fullStr | From Immunodeficiency to Humanization: The Contribution of Mouse Models to Explore HTLV-1 Leukemogenesis |
| title_full_unstemmed | From Immunodeficiency to Humanization: The Contribution of Mouse Models to Explore HTLV-1 Leukemogenesis |
| title_short | From Immunodeficiency to Humanization: The Contribution of Mouse Models to Explore HTLV-1 Leukemogenesis |
| title_sort | from immunodeficiency to humanization the contribution of mouse models to explore htlv 1 leukemogenesis |
| topic | adult T cell leukemia/lymphoma HTLV-1 humanized mouse models oncogenesis |
| url | http://www.mdpi.com/1999-4915/7/12/2944 |
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