TNFR1-d2 carrying the p.(Thr79Met) pathogenic variant is a potential novel actor of TNFα/TNFR1 signalling regulation in the pathophysiology of TRAPS

TNFR1-d2 carrying the p.(Thr79Met) pathogenic variant is a potential novel actor of TNFα/TNFR1 signalling regulation in the pathophysiology of TRAPS

Abstract Binding of tumour necrosis factor α (TNFα) to its receptor (TNFR1) is critical for both survival and death cellular pathways. TNFα/TNFR1 signalling is complex and tightly regulated at different levels to control cell fate decisions. Previously, we identified TNFR1-d2, an exon 2-spliced tran...

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Main Authors: Cécile Rittore, Déborah Méchin, Elodie Sanchez, Léa Marinèche, Vuthy Ea, Stephan Soler, Marion Vereecke, Aude Mallavialle, Eric Richard, Isabelle Duroux-Richard, Florence Apparailly, Isabelle Touitou, Sylvie Grandemange
格式: Article
語言:English
出版: Nature Portfolio 2021-02-01
叢編:Scientific Reports
在線閱讀:https://doi.org/10.1038/s41598-021-83539-9

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https://doi.org/10.1038/s41598-021-83539-9

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