A retrospective observational study of intraductal breast papilloma and its coexisting lesions: A real‐world experience
Abstract Background Breast intraductal papilloma is a heterogeneous group. The aim of the study is to investigate the intraductal breast papilloma and its coexisting lesions retrospectively in real‐world practice. Methods We retrospectively identified 4450 intraductal breast papilloma and its coexis...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-10-01
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| Series: | Cancer Medicine |
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| Online Access: | https://doi.org/10.1002/cam4.3308 |
| _version_ | 1818402447578628096 |
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| author | Xiaona Li Huan Wang Zhe Sun Chuifeng Fan Feng Jin Xiaoyun Mao |
| author_facet | Xiaona Li Huan Wang Zhe Sun Chuifeng Fan Feng Jin Xiaoyun Mao |
| author_sort | Xiaona Li |
| collection | DOAJ |
| description | Abstract Background Breast intraductal papilloma is a heterogeneous group. The aim of the study is to investigate the intraductal breast papilloma and its coexisting lesions retrospectively in real‐world practice. Methods We retrospectively identified 4450 intraductal breast papilloma and its coexisting lesions. Results About 18.36% of intraductal papilloma coexisted with malignant lesions of the breast, 37.33% coexisted with atypia hyperplasia (AH), 25.24% coexisted with benign lesions, and only 19.10% coexisted without concomitant lesions. In addition, 36.80% of intraductal breast papilloma had nipple discharge, 51.46% had a palpable breast mass, and 16.45% had both nipple discharge and a palpable breast mass. About 28.18% experienced discomfort or were asymptomatic. Furthermore, 98.99% had ultrasound abnormalities, and 53.06% had intraductal hypoechogenicity upon ultrasound. 31.89% had mammographic distortion, and 14.45% had microcalcification upon mammography. Intraductal breast papilloma with malignancy had significant correlations with clinical manifestations. Conclusion Coexisting malignancy was also related to ultrasound abnormality (BIRADS 4C and 5), mammographic distortion, and microcalcification upon mammography but was not related to the intraductal hypoechoic upon ultrasound. Coexisting atypical hyperplasia correlated with nipple discharge but not palpable mass, mammographic distortion, or intraductal hypoechoic upon ultrasound. The coexisting AH was also related to abnormality upon ultrasound or microcalcification compared with the benign lesions. The intraductal papilloma coexists with malignancy or AH accounted for more than 50%, and the clinical information on papilloma and its coexisting lesions is nonspecific. We recommended surgical treatment for benign intraductal papillary lesions. |
| first_indexed | 2024-12-14T08:08:31Z |
| format | Article |
| id | doaj.art-a4e9ac8a91c94325b08fc5914e20c076 |
| institution | Directory Open Access Journal |
| issn | 2045-7634 |
| language | English |
| last_indexed | 2024-12-14T08:08:31Z |
| publishDate | 2020-10-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Medicine |
| spelling | doaj.art-a4e9ac8a91c94325b08fc5914e20c0762022-12-21T23:10:07ZengWileyCancer Medicine2045-76342020-10-019207751776210.1002/cam4.3308A retrospective observational study of intraductal breast papilloma and its coexisting lesions: A real‐world experienceXiaona Li0Huan Wang1Zhe Sun2Chuifeng Fan3Feng Jin4Xiaoyun Mao5Department of Breast Surgery The First Affiliated Hospital of China Medical University & School of Fundamental Science China Medical University Shenyang People’s Republic of ChinaDepartment of Gynecology The First Affiliated Hospital of China Medical University Shenyang People’s Republic of ChinaDepartment of Breast Surgery The First Affiliated Hospital of China Medical University Shenyang People’s Republic of ChinaDepartment of Pathology The First Affiliated Hospital and College of Basic Medical Sciences of China Medical University Shenyang People’s Republic of ChinaDepartment of Breast Surgery The First Affiliated Hospital of China Medical University Shenyang People’s Republic of ChinaDepartment of Breast Surgery The First Affiliated Hospital of China Medical University Shenyang People’s Republic of ChinaAbstract Background Breast intraductal papilloma is a heterogeneous group. The aim of the study is to investigate the intraductal breast papilloma and its coexisting lesions retrospectively in real‐world practice. Methods We retrospectively identified 4450 intraductal breast papilloma and its coexisting lesions. Results About 18.36% of intraductal papilloma coexisted with malignant lesions of the breast, 37.33% coexisted with atypia hyperplasia (AH), 25.24% coexisted with benign lesions, and only 19.10% coexisted without concomitant lesions. In addition, 36.80% of intraductal breast papilloma had nipple discharge, 51.46% had a palpable breast mass, and 16.45% had both nipple discharge and a palpable breast mass. About 28.18% experienced discomfort or were asymptomatic. Furthermore, 98.99% had ultrasound abnormalities, and 53.06% had intraductal hypoechogenicity upon ultrasound. 31.89% had mammographic distortion, and 14.45% had microcalcification upon mammography. Intraductal breast papilloma with malignancy had significant correlations with clinical manifestations. Conclusion Coexisting malignancy was also related to ultrasound abnormality (BIRADS 4C and 5), mammographic distortion, and microcalcification upon mammography but was not related to the intraductal hypoechoic upon ultrasound. Coexisting atypical hyperplasia correlated with nipple discharge but not palpable mass, mammographic distortion, or intraductal hypoechoic upon ultrasound. The coexisting AH was also related to abnormality upon ultrasound or microcalcification compared with the benign lesions. The intraductal papilloma coexists with malignancy or AH accounted for more than 50%, and the clinical information on papilloma and its coexisting lesions is nonspecific. We recommended surgical treatment for benign intraductal papillary lesions.https://doi.org/10.1002/cam4.3308breast cancerintraductal breast papillomareal‐world experience |
| spellingShingle | Xiaona Li Huan Wang Zhe Sun Chuifeng Fan Feng Jin Xiaoyun Mao A retrospective observational study of intraductal breast papilloma and its coexisting lesions: A real‐world experience Cancer Medicine breast cancer intraductal breast papilloma real‐world experience |
| title | A retrospective observational study of intraductal breast papilloma and its coexisting lesions: A real‐world experience |
| title_full | A retrospective observational study of intraductal breast papilloma and its coexisting lesions: A real‐world experience |
| title_fullStr | A retrospective observational study of intraductal breast papilloma and its coexisting lesions: A real‐world experience |
| title_full_unstemmed | A retrospective observational study of intraductal breast papilloma and its coexisting lesions: A real‐world experience |
| title_short | A retrospective observational study of intraductal breast papilloma and its coexisting lesions: A real‐world experience |
| title_sort | retrospective observational study of intraductal breast papilloma and its coexisting lesions a real world experience |
| topic | breast cancer intraductal breast papilloma real‐world experience |
| url | https://doi.org/10.1002/cam4.3308 |
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