Different evasion strategies in multiple myeloma
Multiple myeloma is the second most common malignant hematologic malignancy which evolved different strategies for immune escape from the host immune surveillance and drug resistance, including uncontrolled proliferation of malignant plasma cells in the bone marrow, genetic mutations, or deletion of...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-02-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1346211/full |
| _version_ | 1797299775870074880 |
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| author | Chaofan Wang Wanting Wang Moran Wang Jun Deng Chunyan Sun Yu Hu Shanshan Luo |
| author_facet | Chaofan Wang Wanting Wang Moran Wang Jun Deng Chunyan Sun Yu Hu Shanshan Luo |
| author_sort | Chaofan Wang |
| collection | DOAJ |
| description | Multiple myeloma is the second most common malignant hematologic malignancy which evolved different strategies for immune escape from the host immune surveillance and drug resistance, including uncontrolled proliferation of malignant plasma cells in the bone marrow, genetic mutations, or deletion of tumor antigens to escape from special targets and so. Therefore, it is a big challenge to efficiently treat multiple myeloma patients. Despite recent applications of immunomodulatory drugs (IMiDS), protease inhibitors (PI), targeted monoclonal antibodies (mAb), and even hematopoietic stem cell transplantation (HSCT), it remains hardly curable. Summarizing the possible evasion strategies can help design specific drugs for multiple myeloma treatment. This review aims to provide an integrative overview of the intrinsic and extrinsic evasion mechanisms as well as recently discovered microbiota utilized by multiple myeloma for immune evasion and drug resistance, hopefully providing a theoretical basis for the rational design of specific immunotherapies or drug combinations to prevent the uncontrolled proliferation of MM, overcome drug resistance and improve patient survival. |
| first_indexed | 2024-03-07T22:56:31Z |
| format | Article |
| id | doaj.art-a4e9cec05b774b4f95e7db096864e22f |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-03-07T22:56:31Z |
| publishDate | 2024-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-a4e9cec05b774b4f95e7db096864e22f2024-02-23T04:22:26ZengFrontiers Media S.A.Frontiers in Immunology1664-32242024-02-011510.3389/fimmu.2024.13462111346211Different evasion strategies in multiple myelomaChaofan WangWanting WangMoran WangJun DengChunyan SunYu HuShanshan LuoMultiple myeloma is the second most common malignant hematologic malignancy which evolved different strategies for immune escape from the host immune surveillance and drug resistance, including uncontrolled proliferation of malignant plasma cells in the bone marrow, genetic mutations, or deletion of tumor antigens to escape from special targets and so. Therefore, it is a big challenge to efficiently treat multiple myeloma patients. Despite recent applications of immunomodulatory drugs (IMiDS), protease inhibitors (PI), targeted monoclonal antibodies (mAb), and even hematopoietic stem cell transplantation (HSCT), it remains hardly curable. Summarizing the possible evasion strategies can help design specific drugs for multiple myeloma treatment. This review aims to provide an integrative overview of the intrinsic and extrinsic evasion mechanisms as well as recently discovered microbiota utilized by multiple myeloma for immune evasion and drug resistance, hopefully providing a theoretical basis for the rational design of specific immunotherapies or drug combinations to prevent the uncontrolled proliferation of MM, overcome drug resistance and improve patient survival.https://www.frontiersin.org/articles/10.3389/fimmu.2024.1346211/fullmultiple myelomaevasionextrinsic mechanismintrinsic mechanismimmunology |
| spellingShingle | Chaofan Wang Wanting Wang Moran Wang Jun Deng Chunyan Sun Yu Hu Shanshan Luo Different evasion strategies in multiple myeloma Frontiers in Immunology multiple myeloma evasion extrinsic mechanism intrinsic mechanism immunology |
| title | Different evasion strategies in multiple myeloma |
| title_full | Different evasion strategies in multiple myeloma |
| title_fullStr | Different evasion strategies in multiple myeloma |
| title_full_unstemmed | Different evasion strategies in multiple myeloma |
| title_short | Different evasion strategies in multiple myeloma |
| title_sort | different evasion strategies in multiple myeloma |
| topic | multiple myeloma evasion extrinsic mechanism intrinsic mechanism immunology |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1346211/full |
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