Functionalization of electrospun PLA fibers using amphiphilic block copolymers for use in carboxy-methyl-cellulose hydrogel composites
Carboxy-methyl-cellulose (CMC) hydrogels, prepared in the presence of a crosslinker and photoinitiator, were reinforced with 3.7 wt% electrospun PLA fibers to create CMC hydrogel composites. To improve fiber-matrix adhesion, electrospun fiber mats based on hybrids of PLA and amphiphilic block copoly...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2020-07-01
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| Series: | Nanocomposites |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/20550324.2020.1784600 |
| _version_ | 1818401424063594496 |
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| author | Xi Zhang William Megone Ton Peijs Julien E. Gautrot |
| author_facet | Xi Zhang William Megone Ton Peijs Julien E. Gautrot |
| author_sort | Xi Zhang |
| collection | DOAJ |
| description | Carboxy-methyl-cellulose (CMC) hydrogels, prepared in the presence of a crosslinker and photoinitiator, were reinforced with 3.7 wt% electrospun PLA fibers to create CMC hydrogel composites. To improve fiber-matrix adhesion, electrospun fiber mats based on hybrids of PLA and amphiphilic block copolymer (BCP) poly(D,L-lactide)-block-poly[2-(dimethylamino)ethyl methacrylate] (PLA-b-PDMAEMA) were produced. The presence of PDMAEMA at the fiber surface induced hydrophilic surface properties, which could be controlled by varying the PDMAEMA chain length. PDMAEMA was quaternized and co-electrospun with PLA fibers, which further enhanced the interaction between fibers and hydrogel matrix via ionic interactions. Physicochemical properties of the electrospun fiber mats and their CMC hydrogel based composites were assessed and revealed a nearly two orders of magnitude increase in modulus. Continuous electrospun fiber mats were chopped into discontinuous fibers to create short fiber reinforced CMC hydrogels. Rheological properties of these reinforced hydrogels incorporating 0.5 wt% discontinuous fibers were evaluated and showed potential as injectable composite systems for biomedical applications. |
| first_indexed | 2024-12-14T07:52:15Z |
| format | Article |
| id | doaj.art-a4e9d12f9749489d8b966f0584ffcf0e |
| institution | Directory Open Access Journal |
| issn | 2055-0332 |
| language | English |
| last_indexed | 2024-12-14T07:52:15Z |
| publishDate | 2020-07-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Nanocomposites |
| spelling | doaj.art-a4e9d12f9749489d8b966f0584ffcf0e2022-12-21T23:10:41ZengTaylor & Francis GroupNanocomposites2055-03322020-07-0163859810.1080/20550324.2020.17846001784600Functionalization of electrospun PLA fibers using amphiphilic block copolymers for use in carboxy-methyl-cellulose hydrogel compositesXi Zhang0William Megone1Ton Peijs2Julien E. Gautrot3School of Engineering and Materials Science, Queen Mary University of LondonSchool of Engineering and Materials Science, Queen Mary University of LondonWMG, Materials Engineering Centre, University of WarwickSchool of Engineering and Materials Science, Queen Mary University of LondonCarboxy-methyl-cellulose (CMC) hydrogels, prepared in the presence of a crosslinker and photoinitiator, were reinforced with 3.7 wt% electrospun PLA fibers to create CMC hydrogel composites. To improve fiber-matrix adhesion, electrospun fiber mats based on hybrids of PLA and amphiphilic block copolymer (BCP) poly(D,L-lactide)-block-poly[2-(dimethylamino)ethyl methacrylate] (PLA-b-PDMAEMA) were produced. The presence of PDMAEMA at the fiber surface induced hydrophilic surface properties, which could be controlled by varying the PDMAEMA chain length. PDMAEMA was quaternized and co-electrospun with PLA fibers, which further enhanced the interaction between fibers and hydrogel matrix via ionic interactions. Physicochemical properties of the electrospun fiber mats and their CMC hydrogel based composites were assessed and revealed a nearly two orders of magnitude increase in modulus. Continuous electrospun fiber mats were chopped into discontinuous fibers to create short fiber reinforced CMC hydrogels. Rheological properties of these reinforced hydrogels incorporating 0.5 wt% discontinuous fibers were evaluated and showed potential as injectable composite systems for biomedical applications.http://dx.doi.org/10.1080/20550324.2020.1784600electrospun fiberspoly(lactide acid)hydrogelscompositesbiomaterials |
| spellingShingle | Xi Zhang William Megone Ton Peijs Julien E. Gautrot Functionalization of electrospun PLA fibers using amphiphilic block copolymers for use in carboxy-methyl-cellulose hydrogel composites Nanocomposites electrospun fibers poly(lactide acid) hydrogels composites biomaterials |
| title | Functionalization of electrospun PLA fibers using amphiphilic block copolymers for use in carboxy-methyl-cellulose hydrogel composites |
| title_full | Functionalization of electrospun PLA fibers using amphiphilic block copolymers for use in carboxy-methyl-cellulose hydrogel composites |
| title_fullStr | Functionalization of electrospun PLA fibers using amphiphilic block copolymers for use in carboxy-methyl-cellulose hydrogel composites |
| title_full_unstemmed | Functionalization of electrospun PLA fibers using amphiphilic block copolymers for use in carboxy-methyl-cellulose hydrogel composites |
| title_short | Functionalization of electrospun PLA fibers using amphiphilic block copolymers for use in carboxy-methyl-cellulose hydrogel composites |
| title_sort | functionalization of electrospun pla fibers using amphiphilic block copolymers for use in carboxy methyl cellulose hydrogel composites |
| topic | electrospun fibers poly(lactide acid) hydrogels composites biomaterials |
| url | http://dx.doi.org/10.1080/20550324.2020.1784600 |
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