Comparison of the effects of silver nanoparticles and silver cobalt nanoparticles on function tests and liver tissue changes in adult male rats
Objective(s): This study aimed to compare impacts of silver nanoparticles and silver cobalt nanoparticles on the hepatic function tests and changes in liver tissues in adult male rats.Materials and Methods: This study was conducted on 49 adult male Wistar rats, each weighing approximately 180-220 gr...
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2019-04-01
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| Series: | Nanomedicine Journal |
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| Online Access: | http://nmj.mums.ac.ir/article_12298_32b92f818ff3f09e9b8c3583708190a0.pdf |
| _version_ | 1818872979622199296 |
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| author | Zohreh Parang Mojdeh Parsaeian Davood Moghadamnia |
| author_facet | Zohreh Parang Mojdeh Parsaeian Davood Moghadamnia |
| author_sort | Zohreh Parang |
| collection | DOAJ |
| description | Objective(s): This study aimed to compare impacts of silver nanoparticles and silver cobalt nanoparticles on the hepatic function tests and changes in liver tissues in adult male rats.Materials and Methods: This study was conducted on 49 adult male Wistar rats, each weighing approximately 180-220 gr. The rats were randomly assigned to seven groups of seven including one control group and six experimental groups. The experimental groups 1 and 2 respectively received 25 and 100 mg/kg of silver nanoparticles synthesized for 75 sec intraperitoneally for 14 days. Experimental group 3 received silver nanoparticles that were synthesized at 300 sec which were administered intraperitoneally in a 25 mg/kg dose for 14 days. The experimental groups 4 and 5 received silver cobalt nanoparticles, whereby silver nanoparticles were synthesized at 75 sec and were administered intraperitoneally in a 25 and 100 mg/kg dose for 14 days, respectively. Finally, experimental group 6 received a 25 mg/kg dose of silver cobalt nanoparticles, intraperitoneally for 14 days, with the silver nanoparticles synthesized for 300 sec. At the end of this period, the serum levels of hepatic enzymes, albumin, and total protein were measured and tissue changes were evaluated in this study.Results: The mean serum levels of AST, total protein, and albumin in the experimental groups 1 and 3 increased significantly compared to the control group. Similarly, the mean serum levels of ALT and ALP in the experimental group 3 showed a significant increase in comparison with the control group. The mean of liver weight in all experimental groups was significantly higher than the control group(P |
| first_indexed | 2024-12-19T12:47:25Z |
| format | Article |
| id | doaj.art-a4e9ec943f70425f98f336afcde4eb58 |
| institution | Directory Open Access Journal |
| issn | 2322-3049 2322-5904 |
| language | English |
| last_indexed | 2024-12-19T12:47:25Z |
| publishDate | 2019-04-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Nanomedicine Journal |
| spelling | doaj.art-a4e9ec943f70425f98f336afcde4eb582022-12-21T20:20:43ZengMashhad University of Medical SciencesNanomedicine Journal2322-30492322-59042019-04-016212813510.22038/nmj.2019.06.000712298Comparison of the effects of silver nanoparticles and silver cobalt nanoparticles on function tests and liver tissue changes in adult male ratsZohreh Parang0Mojdeh Parsaeian1Davood Moghadamnia2Department of Physics, Shiraz Branch, Islamic Azad University, Shiraz, IranDepartment of Physics, Shiraz Branch, Islamic Azad University, Shiraz, IranYoung Researchers and Elite Club, Shiraz Branch, Islamic Azad University, Shiraz, IranObjective(s): This study aimed to compare impacts of silver nanoparticles and silver cobalt nanoparticles on the hepatic function tests and changes in liver tissues in adult male rats.Materials and Methods: This study was conducted on 49 adult male Wistar rats, each weighing approximately 180-220 gr. The rats were randomly assigned to seven groups of seven including one control group and six experimental groups. The experimental groups 1 and 2 respectively received 25 and 100 mg/kg of silver nanoparticles synthesized for 75 sec intraperitoneally for 14 days. Experimental group 3 received silver nanoparticles that were synthesized at 300 sec which were administered intraperitoneally in a 25 mg/kg dose for 14 days. The experimental groups 4 and 5 received silver cobalt nanoparticles, whereby silver nanoparticles were synthesized at 75 sec and were administered intraperitoneally in a 25 and 100 mg/kg dose for 14 days, respectively. Finally, experimental group 6 received a 25 mg/kg dose of silver cobalt nanoparticles, intraperitoneally for 14 days, with the silver nanoparticles synthesized for 300 sec. At the end of this period, the serum levels of hepatic enzymes, albumin, and total protein were measured and tissue changes were evaluated in this study.Results: The mean serum levels of AST, total protein, and albumin in the experimental groups 1 and 3 increased significantly compared to the control group. Similarly, the mean serum levels of ALT and ALP in the experimental group 3 showed a significant increase in comparison with the control group. The mean of liver weight in all experimental groups was significantly higher than the control group(Phttp://nmj.mums.ac.ir/article_12298_32b92f818ff3f09e9b8c3583708190a0.pdfAlbuminHepatic enzymeRatSilver nanoparticlesSilver Cobalt Nanoparticles |
| spellingShingle | Zohreh Parang Mojdeh Parsaeian Davood Moghadamnia Comparison of the effects of silver nanoparticles and silver cobalt nanoparticles on function tests and liver tissue changes in adult male rats Nanomedicine Journal Albumin Hepatic enzyme Rat Silver nanoparticles Silver Cobalt Nanoparticles |
| title | Comparison of the effects of silver nanoparticles and silver cobalt nanoparticles on function tests and liver tissue changes in adult male rats |
| title_full | Comparison of the effects of silver nanoparticles and silver cobalt nanoparticles on function tests and liver tissue changes in adult male rats |
| title_fullStr | Comparison of the effects of silver nanoparticles and silver cobalt nanoparticles on function tests and liver tissue changes in adult male rats |
| title_full_unstemmed | Comparison of the effects of silver nanoparticles and silver cobalt nanoparticles on function tests and liver tissue changes in adult male rats |
| title_short | Comparison of the effects of silver nanoparticles and silver cobalt nanoparticles on function tests and liver tissue changes in adult male rats |
| title_sort | comparison of the effects of silver nanoparticles and silver cobalt nanoparticles on function tests and liver tissue changes in adult male rats |
| topic | Albumin Hepatic enzyme Rat Silver nanoparticles Silver Cobalt Nanoparticles |
| url | http://nmj.mums.ac.ir/article_12298_32b92f818ff3f09e9b8c3583708190a0.pdf |
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