Androgen deprivation therapy may reduce the risk of primary open-angle glaucoma in patients with prostate cancer: a nationwide population-based cohort study
Background: We evaluated the risk of developing primary open-angle glaucoma (POAG) according to androgen deprivation therapy (ADT) status in patients with prostate cancer. Materials and methods: From the nationwide claims database in South Korea, 218,203 men with prostate cancer were identified betw...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-12-01
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| Series: | Prostate International |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2287888221000258 |
| _version_ | 1827849540354441216 |
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| author | Hyun Kyu Ahn Hye Sun Lee Ju-Young Park Do Kyung Kim Min Kim Ho Sik Hwang Jong Won Kim Jee Soo Ha Kang Su Cho |
| author_facet | Hyun Kyu Ahn Hye Sun Lee Ju-Young Park Do Kyung Kim Min Kim Ho Sik Hwang Jong Won Kim Jee Soo Ha Kang Su Cho |
| author_sort | Hyun Kyu Ahn |
| collection | DOAJ |
| description | Background: We evaluated the risk of developing primary open-angle glaucoma (POAG) according to androgen deprivation therapy (ADT) status in patients with prostate cancer. Materials and methods: From the nationwide claims database in South Korea, 218,203 men with prostate cancer were identified between 2008 and 2017. After applying the inclusion and exclusion criteria, a total of 170,701 patients (42,877 in the ADT and non-ADT groups and 127,824 in the non-ADT group) were included in the analysis. To adjust for comorbidities between cohorts, exact matching was performed. Cox proportional hazard regression models were used to estimate adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) of POAG associated with ADT after controlling for potential confounding factors. Results: In the matched cohort, the ADT group had a lower proportion of newly developed POAG than the non-ADT group (2.10% vs. 2.88%, respectively; P < 0.0001). Multivariable analysis revealed that the ADT group had a significantly lower risk of POAG than the non-ADT group (HR, 0.808; 95% CI, 0.739–0.884; P < 0.0001). The risk of POAG was lower in patients who underwent ADT for less than 2 years (HR, 0.782; 95% CI, 0.690–0.886; P = 0.0001) and in those receiving ADT for over 2 years (HR, 0.825; 95% CI, 0.744–0.916; P = 0.0003) compared with the non-ADT group. Conclusions: The use of ADT was associated with a decreased risk of POAG in Korean patients with prostate cancer. Our findings suggest that testosterone may be involved in the pathophysiology of POAG, and this should be confirmed through further studies. |
| first_indexed | 2024-03-12T10:07:36Z |
| format | Article |
| id | doaj.art-a4eae11fef4b4dcc93de86ac01aa48d7 |
| institution | Directory Open Access Journal |
| issn | 2287-8882 |
| language | English |
| last_indexed | 2024-03-12T10:07:36Z |
| publishDate | 2021-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Prostate International |
| spelling | doaj.art-a4eae11fef4b4dcc93de86ac01aa48d72023-09-02T11:10:50ZengElsevierProstate International2287-88822021-12-0194197202Androgen deprivation therapy may reduce the risk of primary open-angle glaucoma in patients with prostate cancer: a nationwide population-based cohort studyHyun Kyu Ahn0Hye Sun Lee1Ju-Young Park2Do Kyung Kim3Min Kim4Ho Sik Hwang5Jong Won Kim6Jee Soo Ha7Kang Su Cho8Department of Urology, College of Medicine, Ewha Womans University, Seoul, KoreaBiostatistics Collaboration Unit, Yonsei University College of Medicine, Seoul, KoreaDepartment of Statistics and Data Science, Yonsei University, Seoul, KoreaDepartment of Urology, Soonchunhyang University Hospital, Soonchunhyang University College of Medicine, Seoul, KoreaDepartment of Ophthalmology, Institute of Vision Research, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, KoreaDepartment of Ophthalmology, Yeouido St. Mary's Hospital, The Catholic University of Korea, Seoul, KoreaDepartment of Urology, Inha University School of Medicine, Incheon, KoreaDepartment of Urology, Prostate Cancer Center, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, KoreaDepartment of Urology, Prostate Cancer Center, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea; Corresponding author. Departments of Urology, Gangnam Severance Hospital, Urological Science Institute, Yonsei University College of Medicine, 211 Eonju-ro, Gangnam-gu, Seoul, 06273, Korea.Background: We evaluated the risk of developing primary open-angle glaucoma (POAG) according to androgen deprivation therapy (ADT) status in patients with prostate cancer. Materials and methods: From the nationwide claims database in South Korea, 218,203 men with prostate cancer were identified between 2008 and 2017. After applying the inclusion and exclusion criteria, a total of 170,701 patients (42,877 in the ADT and non-ADT groups and 127,824 in the non-ADT group) were included in the analysis. To adjust for comorbidities between cohorts, exact matching was performed. Cox proportional hazard regression models were used to estimate adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) of POAG associated with ADT after controlling for potential confounding factors. Results: In the matched cohort, the ADT group had a lower proportion of newly developed POAG than the non-ADT group (2.10% vs. 2.88%, respectively; P < 0.0001). Multivariable analysis revealed that the ADT group had a significantly lower risk of POAG than the non-ADT group (HR, 0.808; 95% CI, 0.739–0.884; P < 0.0001). The risk of POAG was lower in patients who underwent ADT for less than 2 years (HR, 0.782; 95% CI, 0.690–0.886; P = 0.0001) and in those receiving ADT for over 2 years (HR, 0.825; 95% CI, 0.744–0.916; P = 0.0003) compared with the non-ADT group. Conclusions: The use of ADT was associated with a decreased risk of POAG in Korean patients with prostate cancer. Our findings suggest that testosterone may be involved in the pathophysiology of POAG, and this should be confirmed through further studies.http://www.sciencedirect.com/science/article/pii/S2287888221000258GlaucomaProstate cancerTestosterone |
| spellingShingle | Hyun Kyu Ahn Hye Sun Lee Ju-Young Park Do Kyung Kim Min Kim Ho Sik Hwang Jong Won Kim Jee Soo Ha Kang Su Cho Androgen deprivation therapy may reduce the risk of primary open-angle glaucoma in patients with prostate cancer: a nationwide population-based cohort study Prostate International Glaucoma Prostate cancer Testosterone |
| title | Androgen deprivation therapy may reduce the risk of primary open-angle glaucoma in patients with prostate cancer: a nationwide population-based cohort study |
| title_full | Androgen deprivation therapy may reduce the risk of primary open-angle glaucoma in patients with prostate cancer: a nationwide population-based cohort study |
| title_fullStr | Androgen deprivation therapy may reduce the risk of primary open-angle glaucoma in patients with prostate cancer: a nationwide population-based cohort study |
| title_full_unstemmed | Androgen deprivation therapy may reduce the risk of primary open-angle glaucoma in patients with prostate cancer: a nationwide population-based cohort study |
| title_short | Androgen deprivation therapy may reduce the risk of primary open-angle glaucoma in patients with prostate cancer: a nationwide population-based cohort study |
| title_sort | androgen deprivation therapy may reduce the risk of primary open angle glaucoma in patients with prostate cancer a nationwide population based cohort study |
| topic | Glaucoma Prostate cancer Testosterone |
| url | http://www.sciencedirect.com/science/article/pii/S2287888221000258 |
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