Antimicrobial susceptibility of urinary Klebsiella pneumoniae and the emergence of carbapenem-resistant strains: A retrospective study from a university hospital in Morocco, North Africa
Introduction: Urinary tract infections (UTIs) due to multi-drug resistant Klebsiella pneumoniae (K. pneumoniae) strains are increasing worldwide and have become a major public health problem. Objectives: The aim of this study was to determine the current and local antimicrobial susceptibility of uri...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2015-03-01
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| Series: | African Journal of Urology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S111057041500003X |
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| author | M.C. El Bouamri L. Arsalane Y. El Kamouni S. Zouhair |
| author_facet | M.C. El Bouamri L. Arsalane Y. El Kamouni S. Zouhair |
| author_sort | M.C. El Bouamri |
| collection | DOAJ |
| description | Introduction: Urinary tract infections (UTIs) due to multi-drug resistant Klebsiella pneumoniae (K. pneumoniae) strains are increasing worldwide and have become a major public health problem.
Objectives: The aim of this study was to determine the current and local antimicrobial susceptibility of urinary K. pneumoniae isolated from inpatients and outpatients in a university hospital.
Subjects and methods: A retrospective study was carried out, covering a 3-year period from January 2010 to December 2012. It focused on all the K. pneumoniae strains isolated from the urine samples analyzed at the microbiology laboratory of the Avicenne Teaching Hospital, Marrakech, Morocco, North Africa.
Results: K. pneumoniae represented 22% of all the urinary Enterobacteriaceae isolated during the study period. The bacterial resistance rates of K. pneumoniae isolates not producing extended-spectrum β-lactamase (ESBL) were as follows: trimethoprim–sulfamethoxazole “T/S” (61%), amoxicillin/clavulanic acid (51%), ciprofloxacin (32%), gentamicin (21%) and amikacin (11%). ESBL-producing K. pneumoniae strains accounted for 25.5% of all the urinary K. pneumoniae isolates and showed resistance to T/S (89%), gentamicin (89%), ciprofloxacin (84%) and amikacin (50%). For the first time in our region, we also noted the emergence of carbapenem-resistant strains that accounted for 7% of all the urinary ESBL-producing K. pneumoniae isolates.
Conclusions: Antimicrobial susceptibility testing of urinary K. pneumoniae isolates showed a significantly high resistance to commonly used antimicrobial agents. These data highlight the need for regular surveillance of microbial resistance to improve infection control and guide the use of antimicrobial agents. |
| first_indexed | 2024-12-10T23:28:14Z |
| format | Article |
| id | doaj.art-a4ede663940e4ef98115e8155fba4796 |
| institution | Directory Open Access Journal |
| issn | 1110-5704 |
| language | English |
| last_indexed | 2024-12-10T23:28:14Z |
| publishDate | 2015-03-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | African Journal of Urology |
| spelling | doaj.art-a4ede663940e4ef98115e8155fba47962022-12-22T01:29:29ZengSpringerOpenAfrican Journal of Urology1110-57042015-03-01211364010.1016/j.afju.2014.10.004Antimicrobial susceptibility of urinary Klebsiella pneumoniae and the emergence of carbapenem-resistant strains: A retrospective study from a university hospital in Morocco, North AfricaM.C. El Bouamri0L. Arsalane1Y. El Kamouni2S. Zouhair3The Microbiology Laboratory of the Avicenne Military Teaching Hospital of Marrakech, MoroccoThe Microbiology Laboratory of the Avicenne Military Teaching Hospital of Marrakech, MoroccoThe Microbiology Laboratory of the Avicenne Military Teaching Hospital of Marrakech, MoroccoThe Microbiology Laboratory of the Avicenne Military Teaching Hospital of Marrakech, MoroccoIntroduction: Urinary tract infections (UTIs) due to multi-drug resistant Klebsiella pneumoniae (K. pneumoniae) strains are increasing worldwide and have become a major public health problem. Objectives: The aim of this study was to determine the current and local antimicrobial susceptibility of urinary K. pneumoniae isolated from inpatients and outpatients in a university hospital. Subjects and methods: A retrospective study was carried out, covering a 3-year period from January 2010 to December 2012. It focused on all the K. pneumoniae strains isolated from the urine samples analyzed at the microbiology laboratory of the Avicenne Teaching Hospital, Marrakech, Morocco, North Africa. Results: K. pneumoniae represented 22% of all the urinary Enterobacteriaceae isolated during the study period. The bacterial resistance rates of K. pneumoniae isolates not producing extended-spectrum β-lactamase (ESBL) were as follows: trimethoprim–sulfamethoxazole “T/S” (61%), amoxicillin/clavulanic acid (51%), ciprofloxacin (32%), gentamicin (21%) and amikacin (11%). ESBL-producing K. pneumoniae strains accounted for 25.5% of all the urinary K. pneumoniae isolates and showed resistance to T/S (89%), gentamicin (89%), ciprofloxacin (84%) and amikacin (50%). For the first time in our region, we also noted the emergence of carbapenem-resistant strains that accounted for 7% of all the urinary ESBL-producing K. pneumoniae isolates. Conclusions: Antimicrobial susceptibility testing of urinary K. pneumoniae isolates showed a significantly high resistance to commonly used antimicrobial agents. These data highlight the need for regular surveillance of microbial resistance to improve infection control and guide the use of antimicrobial agents.http://www.sciencedirect.com/science/article/pii/S111057041500003XUrinaryKlebsiella pneumoniaeAntimicrobial resistance |
| spellingShingle | M.C. El Bouamri L. Arsalane Y. El Kamouni S. Zouhair Antimicrobial susceptibility of urinary Klebsiella pneumoniae and the emergence of carbapenem-resistant strains: A retrospective study from a university hospital in Morocco, North Africa African Journal of Urology Urinary Klebsiella pneumoniae Antimicrobial resistance |
| title | Antimicrobial susceptibility of urinary Klebsiella pneumoniae and the emergence of carbapenem-resistant strains: A retrospective study from a university hospital in Morocco, North Africa |
| title_full | Antimicrobial susceptibility of urinary Klebsiella pneumoniae and the emergence of carbapenem-resistant strains: A retrospective study from a university hospital in Morocco, North Africa |
| title_fullStr | Antimicrobial susceptibility of urinary Klebsiella pneumoniae and the emergence of carbapenem-resistant strains: A retrospective study from a university hospital in Morocco, North Africa |
| title_full_unstemmed | Antimicrobial susceptibility of urinary Klebsiella pneumoniae and the emergence of carbapenem-resistant strains: A retrospective study from a university hospital in Morocco, North Africa |
| title_short | Antimicrobial susceptibility of urinary Klebsiella pneumoniae and the emergence of carbapenem-resistant strains: A retrospective study from a university hospital in Morocco, North Africa |
| title_sort | antimicrobial susceptibility of urinary klebsiella pneumoniae and the emergence of carbapenem resistant strains a retrospective study from a university hospital in morocco north africa |
| topic | Urinary Klebsiella pneumoniae Antimicrobial resistance |
| url | http://www.sciencedirect.com/science/article/pii/S111057041500003X |
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