Challenges and Therapeutic Opportunities of Autophagy in Cancer Therapy
Autophagy is a physiological cellular process that is crucial for development and can occurs in response to nutrient deprivation or metabolic disorders. Interestingly, autophagy plays a dual role in cancer cells—while in some situations, it has a cytoprotective effect that causes chemotherapy resist...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-11-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/12/11/3461 |
| _version_ | 1797547288109776896 |
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| author | Valdenizia R. Silva Sara P. Neves Luciano de S. Santos Rosane B. Dias Daniel P. Bezerra |
| author_facet | Valdenizia R. Silva Sara P. Neves Luciano de S. Santos Rosane B. Dias Daniel P. Bezerra |
| author_sort | Valdenizia R. Silva |
| collection | DOAJ |
| description | Autophagy is a physiological cellular process that is crucial for development and can occurs in response to nutrient deprivation or metabolic disorders. Interestingly, autophagy plays a dual role in cancer cells—while in some situations, it has a cytoprotective effect that causes chemotherapy resistance, in others, it has a cytotoxic effect in which some compounds induce autophagy-mediated cell death. In this review, we summarize strategies aimed at autophagy for the treatment of cancer, including studies of drugs that can modulate autophagy-mediated resistance, and/or drugs that cause autophagy-mediated cancer cell death. In addition, the role of autophagy in the biology of cancer stem cells has also been discussed. |
| first_indexed | 2024-03-10T14:42:12Z |
| format | Article |
| id | doaj.art-a4f21473a27645c389b9230b39881eed |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T14:42:12Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-a4f21473a27645c389b9230b39881eed2023-11-20T21:43:08ZengMDPI AGCancers2072-66942020-11-011211346110.3390/cancers12113461Challenges and Therapeutic Opportunities of Autophagy in Cancer TherapyValdenizia R. Silva0Sara P. Neves1Luciano de S. Santos2Rosane B. Dias3Daniel P. Bezerra4Gonçalo Moniz Institute, Oswaldo Cruz Foundation (IGM-FIOCRUZ/BA), Salvador 40296-710, BrazilGonçalo Moniz Institute, Oswaldo Cruz Foundation (IGM-FIOCRUZ/BA), Salvador 40296-710, BrazilGonçalo Moniz Institute, Oswaldo Cruz Foundation (IGM-FIOCRUZ/BA), Salvador 40296-710, BrazilGonçalo Moniz Institute, Oswaldo Cruz Foundation (IGM-FIOCRUZ/BA), Salvador 40296-710, BrazilGonçalo Moniz Institute, Oswaldo Cruz Foundation (IGM-FIOCRUZ/BA), Salvador 40296-710, BrazilAutophagy is a physiological cellular process that is crucial for development and can occurs in response to nutrient deprivation or metabolic disorders. Interestingly, autophagy plays a dual role in cancer cells—while in some situations, it has a cytoprotective effect that causes chemotherapy resistance, in others, it has a cytotoxic effect in which some compounds induce autophagy-mediated cell death. In this review, we summarize strategies aimed at autophagy for the treatment of cancer, including studies of drugs that can modulate autophagy-mediated resistance, and/or drugs that cause autophagy-mediated cancer cell death. In addition, the role of autophagy in the biology of cancer stem cells has also been discussed.https://www.mdpi.com/2072-6694/12/11/3461autophagycancercell deathdrug resistance |
| spellingShingle | Valdenizia R. Silva Sara P. Neves Luciano de S. Santos Rosane B. Dias Daniel P. Bezerra Challenges and Therapeutic Opportunities of Autophagy in Cancer Therapy Cancers autophagy cancer cell death drug resistance |
| title | Challenges and Therapeutic Opportunities of Autophagy in Cancer Therapy |
| title_full | Challenges and Therapeutic Opportunities of Autophagy in Cancer Therapy |
| title_fullStr | Challenges and Therapeutic Opportunities of Autophagy in Cancer Therapy |
| title_full_unstemmed | Challenges and Therapeutic Opportunities of Autophagy in Cancer Therapy |
| title_short | Challenges and Therapeutic Opportunities of Autophagy in Cancer Therapy |
| title_sort | challenges and therapeutic opportunities of autophagy in cancer therapy |
| topic | autophagy cancer cell death drug resistance |
| url | https://www.mdpi.com/2072-6694/12/11/3461 |
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