Default mode intranetwork resting-state functional connectivity is correlated with increased symptom severity in common anxiety disorders: A systematic review and meta-analysis
Background: No study has yet to simultaneously compare generalized anxiety disorder (GAD), panic disorder (PD), and social anxiety disorder (SAD) with respect to restingstate functional connectivity (rsFC) and anxiety symptom severity. Methods: We collected articles from PubMed, PsycINFO, and Scienc...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-12-01
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| Series: | Journal of Affective Disorders Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666915323002123 |
| _version_ | 1797526202898972672 |
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| author | Zachary P. Pierce Jessica M. Black |
| author_facet | Zachary P. Pierce Jessica M. Black |
| author_sort | Zachary P. Pierce |
| collection | DOAJ |
| description | Background: No study has yet to simultaneously compare generalized anxiety disorder (GAD), panic disorder (PD), and social anxiety disorder (SAD) with respect to restingstate functional connectivity (rsFC) and anxiety symptom severity. Methods: We collected articles from PubMed, PsycINFO, and ScienceDirect and subjected articles to seven eligibility criteria to be considered for inclusion. Included articles were screened using the QUADAS-2 to assess article quality. Articles were also subjected to a forest plot, activation likelihood estimation (ALE) meta-analysis, and a multiple regression to measure the effect of anxiety symptom severity and rsFC between conditions. We also subjected our sample to a funnel plot with Egger's test to determine publication bias. Results: Our initial search yielded 1022 studies. After eligibility criteria we retained 30 articles. Quality assessment indicated no major issues with bias or applicability. Our forest plot indicated that all conditions showed a robust effect on anxiety symptom severity when compared with controls. Our ALE meta-analysis showed convergent intranetwork rsFC within the default mode network (DMN) across conditions. Our multiple regression indicated that all conditions exhibited very strong correlations between DMN connectivity and anxiety symptom severity. Funnel plot and Egger's test indicated no presence of publication bias. Limitations: Our sample was limited by the following: No longitudinal data, no specific time series neuroimaging data, some biased demographic data, and the possibility that some studies might have been missed during review. Conclusion: GAD, PD, and SAD appear to exhibit increased intranetwork connectivity in the DMN which correlates with increased severity of anxiety symptoms. |
| first_indexed | 2024-03-10T09:25:54Z |
| format | Article |
| id | doaj.art-a4f4ff83de2e46df893a3655201e88b4 |
| institution | Directory Open Access Journal |
| issn | 2666-9153 |
| language | English |
| last_indexed | 2024-03-10T09:25:54Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Affective Disorders Reports |
| spelling | doaj.art-a4f4ff83de2e46df893a3655201e88b42023-11-22T04:49:12ZengElsevierJournal of Affective Disorders Reports2666-91532023-12-0114100674Default mode intranetwork resting-state functional connectivity is correlated with increased symptom severity in common anxiety disorders: A systematic review and meta-analysisZachary P. Pierce0Jessica M. Black1Community Behavioral Health Center, Riverside Community Care, Milford, MA, USA; Cell to Society Lab, Boston College School of Social Work, Chestnut Hill, MA, USA; Corresponding author at: Cell to Society Lab, Boston College School of Social Work, 140 Commonwealth Avenue, Chestnut Hill, MA 02467, USA.Cell to Society Lab, Boston College School of Social Work, Chestnut Hill, MA, USA; Boston College School of Social Work, Chestnut Hill, MA, USABackground: No study has yet to simultaneously compare generalized anxiety disorder (GAD), panic disorder (PD), and social anxiety disorder (SAD) with respect to restingstate functional connectivity (rsFC) and anxiety symptom severity. Methods: We collected articles from PubMed, PsycINFO, and ScienceDirect and subjected articles to seven eligibility criteria to be considered for inclusion. Included articles were screened using the QUADAS-2 to assess article quality. Articles were also subjected to a forest plot, activation likelihood estimation (ALE) meta-analysis, and a multiple regression to measure the effect of anxiety symptom severity and rsFC between conditions. We also subjected our sample to a funnel plot with Egger's test to determine publication bias. Results: Our initial search yielded 1022 studies. After eligibility criteria we retained 30 articles. Quality assessment indicated no major issues with bias or applicability. Our forest plot indicated that all conditions showed a robust effect on anxiety symptom severity when compared with controls. Our ALE meta-analysis showed convergent intranetwork rsFC within the default mode network (DMN) across conditions. Our multiple regression indicated that all conditions exhibited very strong correlations between DMN connectivity and anxiety symptom severity. Funnel plot and Egger's test indicated no presence of publication bias. Limitations: Our sample was limited by the following: No longitudinal data, no specific time series neuroimaging data, some biased demographic data, and the possibility that some studies might have been missed during review. Conclusion: GAD, PD, and SAD appear to exhibit increased intranetwork connectivity in the DMN which correlates with increased severity of anxiety symptoms.http://www.sciencedirect.com/science/article/pii/S2666915323002123Generalized anxietyPanicSocial anxietyrsfMRIrsFCALE meta-analysis |
| spellingShingle | Zachary P. Pierce Jessica M. Black Default mode intranetwork resting-state functional connectivity is correlated with increased symptom severity in common anxiety disorders: A systematic review and meta-analysis Journal of Affective Disorders Reports Generalized anxiety Panic Social anxiety rsfMRI rsFC ALE meta-analysis |
| title | Default mode intranetwork resting-state functional connectivity is correlated with increased symptom severity in common anxiety disorders: A systematic review and meta-analysis |
| title_full | Default mode intranetwork resting-state functional connectivity is correlated with increased symptom severity in common anxiety disorders: A systematic review and meta-analysis |
| title_fullStr | Default mode intranetwork resting-state functional connectivity is correlated with increased symptom severity in common anxiety disorders: A systematic review and meta-analysis |
| title_full_unstemmed | Default mode intranetwork resting-state functional connectivity is correlated with increased symptom severity in common anxiety disorders: A systematic review and meta-analysis |
| title_short | Default mode intranetwork resting-state functional connectivity is correlated with increased symptom severity in common anxiety disorders: A systematic review and meta-analysis |
| title_sort | default mode intranetwork resting state functional connectivity is correlated with increased symptom severity in common anxiety disorders a systematic review and meta analysis |
| topic | Generalized anxiety Panic Social anxiety rsfMRI rsFC ALE meta-analysis |
| url | http://www.sciencedirect.com/science/article/pii/S2666915323002123 |
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