Free Thyroxine and Triiodothyronine are Associated with Renal Function in Normoalbuminuric Euthyroid Type 1 Diabetic Patients
Both hypothyroidism and hyperthyroidism affect renal function. The aim of this study was to investigate the relationship between parameters of thyroid function (TSH, free triiodothyronine (FT3), and free thyroxine (FT4)) and parameters of renal function in patients with type 1 diabetes (T1DM). Th...
| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | English |
| Publicado em: |
Sestre Milosrdnice University hospital, Institute of Clinical Medical Research
2021-01-01
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| Colecção: | Acta Clinica Croatica |
| Assuntos: | |
| Acesso em linha: | https://hrcak.srce.hr/file/378573 |
| _version_ | 1827282256212787200 |
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| author | Tomislav Bulum Marijana Vučić Lovrenčić Ingrid Prkačin Lea Duvnjak |
| author_facet | Tomislav Bulum Marijana Vučić Lovrenčić Ingrid Prkačin Lea Duvnjak |
| author_sort | Tomislav Bulum |
| collection | DOAJ |
| description | Both hypothyroidism and hyperthyroidism affect renal function. The aim of this
study was to investigate the relationship between parameters of thyroid function (TSH, free triiodothyronine
(FT3), and free thyroxine (FT4)) and parameters of renal function in patients with type 1
diabetes (T1DM). The study included 272 T1DM with normoalbuminuria and estimated glomerular
filtration rate (eGFR) > 60 ml/min-11.73m-2, normal thyroid function, and without antihypertensive
and antihyperlipidemic therapy. TSH significantly correlated with urinary albumin excretion rate
(UAE) (r=-0.15, p<0.05) and fT3 with serum creatinine (r=0.12, p<0.05). Furthermore, fT4 significantly
correlated with all renal function parameters (serum creatinine, eGFR and UAE (r=-0.12, 0.34
and -0.13, respectively, for all p<0.05)). Patients in the highest quartile of fT4 had significantly higher
eGFR levels compared to those in the lowest quartile (116 vs. 101 ml/min-11.73m-2, p<0.001). In logistic
regression analysis, after adjustment for covariates, fT3 and fT4 were significantly associated
with worsening of renal function parameters with odds ratios of 0.75 to 1.29. This study, conducted in
euthyroid T1DM with normoalbuminuria and eGFR > 60 ml/min-11.73m-2 without therapeutic intervention,
suggests that the thyroid function may be connected with renal function parameters even
in the euthyroid range. |
| first_indexed | 2024-04-24T09:15:05Z |
| format | Article |
| id | doaj.art-a4f582c9eb1e47149926a2e357b47704 |
| institution | Directory Open Access Journal |
| issn | 0353-9466 1333-9451 |
| language | English |
| last_indexed | 2024-04-24T09:15:05Z |
| publishDate | 2021-01-01 |
| publisher | Sestre Milosrdnice University hospital, Institute of Clinical Medical Research |
| record_format | Article |
| series | Acta Clinica Croatica |
| spelling | doaj.art-a4f582c9eb1e47149926a2e357b477042024-04-15T17:04:28ZengSestre Milosrdnice University hospital, Institute of Clinical Medical ResearchActa Clinica Croatica0353-94661333-94512021-01-0160.Supplement 1394510.20471/acc.2021.60.s1.06Free Thyroxine and Triiodothyronine are Associated with Renal Function in Normoalbuminuric Euthyroid Type 1 Diabetic PatientsTomislav Bulum0Marijana Vučić Lovrenčić1Ingrid Prkačin2Lea Duvnjak3Vuk Vrhovac Clinic for Diabetes, Endocrinology and Metabolic Diseases, Merkur University Hospital, Zagreb, Croatia; Medical School, University of Zagreb, Zagreb, CroatiaClinical Department of Medical Biochemistry and Laboratory Medicine, Merkur University Hospital, Zagreb, CroatiaMedical School, University of Zagreb, Zagreb, Croatia; Department of Internal Medicine, Merkur University Hospital, Zagreb, CroatiaVuk Vrhovac Clinic for Diabetes, Endocrinology and Metabolic Diseases, Merkur University Hospital, Zagreb, Croatia; Medical School, University of Zagreb, Zagreb, CroatiaBoth hypothyroidism and hyperthyroidism affect renal function. The aim of this study was to investigate the relationship between parameters of thyroid function (TSH, free triiodothyronine (FT3), and free thyroxine (FT4)) and parameters of renal function in patients with type 1 diabetes (T1DM). The study included 272 T1DM with normoalbuminuria and estimated glomerular filtration rate (eGFR) > 60 ml/min-11.73m-2, normal thyroid function, and without antihypertensive and antihyperlipidemic therapy. TSH significantly correlated with urinary albumin excretion rate (UAE) (r=-0.15, p<0.05) and fT3 with serum creatinine (r=0.12, p<0.05). Furthermore, fT4 significantly correlated with all renal function parameters (serum creatinine, eGFR and UAE (r=-0.12, 0.34 and -0.13, respectively, for all p<0.05)). Patients in the highest quartile of fT4 had significantly higher eGFR levels compared to those in the lowest quartile (116 vs. 101 ml/min-11.73m-2, p<0.001). In logistic regression analysis, after adjustment for covariates, fT3 and fT4 were significantly associated with worsening of renal function parameters with odds ratios of 0.75 to 1.29. This study, conducted in euthyroid T1DM with normoalbuminuria and eGFR > 60 ml/min-11.73m-2 without therapeutic intervention, suggests that the thyroid function may be connected with renal function parameters even in the euthyroid range.https://hrcak.srce.hr/file/378573Thyroid hormonesType 1 diabetesRenal functionAlbuminuria |
| spellingShingle | Tomislav Bulum Marijana Vučić Lovrenčić Ingrid Prkačin Lea Duvnjak Free Thyroxine and Triiodothyronine are Associated with Renal Function in Normoalbuminuric Euthyroid Type 1 Diabetic Patients Acta Clinica Croatica Thyroid hormones Type 1 diabetes Renal function Albuminuria |
| title | Free Thyroxine and Triiodothyronine are Associated with Renal Function in Normoalbuminuric Euthyroid Type 1 Diabetic Patients |
| title_full | Free Thyroxine and Triiodothyronine are Associated with Renal Function in Normoalbuminuric Euthyroid Type 1 Diabetic Patients |
| title_fullStr | Free Thyroxine and Triiodothyronine are Associated with Renal Function in Normoalbuminuric Euthyroid Type 1 Diabetic Patients |
| title_full_unstemmed | Free Thyroxine and Triiodothyronine are Associated with Renal Function in Normoalbuminuric Euthyroid Type 1 Diabetic Patients |
| title_short | Free Thyroxine and Triiodothyronine are Associated with Renal Function in Normoalbuminuric Euthyroid Type 1 Diabetic Patients |
| title_sort | free thyroxine and triiodothyronine are associated with renal function in normoalbuminuric euthyroid type 1 diabetic patients |
| topic | Thyroid hormones Type 1 diabetes Renal function Albuminuria |
| url | https://hrcak.srce.hr/file/378573 |
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