Adherence to oxidative balance scores and lower odds of non-alcoholic fatty liver disease: a case–control study
Abstract Evidence has also shown that oxidative stress and systemic inflammation, or in other words, disruption of the oxidant and antioxidant balance, can play an important role in the initiation or progression of NAFLD. The purpose of this study was to investigate the associations between the oxid...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-04-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-33407-5 |
| _version_ | 1797846027341922304 |
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| author | Mohammad Hassan Sohouli Pejman Rohani Mahdieh Hosseinzadeh Azita Hekmatdoost |
| author_facet | Mohammad Hassan Sohouli Pejman Rohani Mahdieh Hosseinzadeh Azita Hekmatdoost |
| author_sort | Mohammad Hassan Sohouli |
| collection | DOAJ |
| description | Abstract Evidence has also shown that oxidative stress and systemic inflammation, or in other words, disruption of the oxidant and antioxidant balance, can play an important role in the initiation or progression of NAFLD. The purpose of this study was to investigate the associations between the oxidative balance scores (OBS) and the risk of NAFLD. 552 healthy and 340 patients adult over the age of 18 with NAFLD participated in this case–control research. A validated 168-item quantitative food frequency questionnaire (FFQ) and indicators of physical activity, obesity, and smoking status were used to assess OBS score. The connection between OBS and NAFLD was discovered using binary logistic regression. The mean (± SD) age and (body mass index) BMI of the study population was 40.22 ± 9.79 years and 29.06 ± 3.92 kg/m2, respectively. The mean ± SD of OBS was 41.48 ± 5.23. After adjustment for potential confounders, higher scores of adherence to the OBS conferred a protection for the presence of NAFLD (odds ratio [OR]: 0.29; 95% confidence interval [CI]: 0.15–0.49; P for trend < 0.001). The findings of the present study indicate an approximately 80% reduction in the odds of developing NAFLD with higher OBS adherence in the overall population. However, prospective studies are needed to further investigate this association. |
| first_indexed | 2024-04-09T17:48:26Z |
| format | Article |
| id | doaj.art-a4f6fb1c77fd4ffe9c140c6d561a2cb9 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-09T17:48:26Z |
| publishDate | 2023-04-01 |
| publisher | Nature Portfolio |
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| spelling | doaj.art-a4f6fb1c77fd4ffe9c140c6d561a2cb92023-04-16T11:10:58ZengNature PortfolioScientific Reports2045-23222023-04-011311810.1038/s41598-023-33407-5Adherence to oxidative balance scores and lower odds of non-alcoholic fatty liver disease: a case–control studyMohammad Hassan Sohouli0Pejman Rohani1Mahdieh Hosseinzadeh2Azita Hekmatdoost3Student Research Committee, Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical SciencesPediatric Gastroenterology and Hepatology Research Center, Pediatrics Centre of Excellence, Children’s Medical Center, Tehran University of Medical SciencesDepartment of Nutrition, School of Public Health, Shahid Sadoughi University of Medical SciencesDepartment of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, National Nutrition and Food Technology Research Institute Shahid Beheshti University of Medical SciencesAbstract Evidence has also shown that oxidative stress and systemic inflammation, or in other words, disruption of the oxidant and antioxidant balance, can play an important role in the initiation or progression of NAFLD. The purpose of this study was to investigate the associations between the oxidative balance scores (OBS) and the risk of NAFLD. 552 healthy and 340 patients adult over the age of 18 with NAFLD participated in this case–control research. A validated 168-item quantitative food frequency questionnaire (FFQ) and indicators of physical activity, obesity, and smoking status were used to assess OBS score. The connection between OBS and NAFLD was discovered using binary logistic regression. The mean (± SD) age and (body mass index) BMI of the study population was 40.22 ± 9.79 years and 29.06 ± 3.92 kg/m2, respectively. The mean ± SD of OBS was 41.48 ± 5.23. After adjustment for potential confounders, higher scores of adherence to the OBS conferred a protection for the presence of NAFLD (odds ratio [OR]: 0.29; 95% confidence interval [CI]: 0.15–0.49; P for trend < 0.001). The findings of the present study indicate an approximately 80% reduction in the odds of developing NAFLD with higher OBS adherence in the overall population. However, prospective studies are needed to further investigate this association.https://doi.org/10.1038/s41598-023-33407-5 |
| spellingShingle | Mohammad Hassan Sohouli Pejman Rohani Mahdieh Hosseinzadeh Azita Hekmatdoost Adherence to oxidative balance scores and lower odds of non-alcoholic fatty liver disease: a case–control study Scientific Reports |
| title | Adherence to oxidative balance scores and lower odds of non-alcoholic fatty liver disease: a case–control study |
| title_full | Adherence to oxidative balance scores and lower odds of non-alcoholic fatty liver disease: a case–control study |
| title_fullStr | Adherence to oxidative balance scores and lower odds of non-alcoholic fatty liver disease: a case–control study |
| title_full_unstemmed | Adherence to oxidative balance scores and lower odds of non-alcoholic fatty liver disease: a case–control study |
| title_short | Adherence to oxidative balance scores and lower odds of non-alcoholic fatty liver disease: a case–control study |
| title_sort | adherence to oxidative balance scores and lower odds of non alcoholic fatty liver disease a case control study |
| url | https://doi.org/10.1038/s41598-023-33407-5 |
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