Krüppel-Like Factor 2 Regulates Degradation of Type II Collagen by Suppressing the Expression of Matrix Metalloproteinase (MMP)-13

Krüppel-Like Factor 2 Regulates Degradation of Type II Collagen by Suppressing the Expression of Matrix Metalloproteinase (MMP)-13

Background/Aims: Krüppel-like factor 2 (KLF2) plays an essential role in the inhibition of endothelial cell and macrophage activation during the inflammatory process. However, the roles of KLF2 in chondrocytes and the pathological progression of osteoarthritis (OA) remain unknown. The aim of this st...

Full description

Bibliographic Details
Main Authors:	Yuan Yuan, Honglue Tan, Pengyi Dai
Format:	Article
Language:	English
Published:	Cell Physiol Biochem Press GmbH & Co KG 2017-08-01
Series:	Cellular Physiology and Biochemistry
Subjects:	Krüppel-like factor 2 (KLF2) Matrix metalloproteinases (MMP)-13 Type II collagen Interleukin-1β Osteoarthritis
Online Access:	http://www.karger.com/Article/FullText/479991

Similar Items

Krüppel-like Factor-9 and Krüppel-like Factor-13: Highly Related, Multi-Functional, Transcriptional Repressors and Activators of Oncogenesis
by: Frank A. Simmen, et al.
Published: (2023-11-01)

Overview of MMP-13 as a Promising Target for the Treatment of Osteoarthritis
by: Qichan Hu, et al.
Published: (2021-02-01)

Kruppel-like factor 13 inhibits cell proliferation of gastric cancer by inducing autophagic degradation of β-catenin
by: Youxiang Ding, et al.
Published: (2022-11-01)

TIPE2 Mediates the Suppressive Effects of Shikonin on MMP13 in Osteosarcoma Cells
by: Biyong Deng, et al.
Published: (2015-12-01)

New insights on the MMP-13 regulatory network in the pathogenesis of early osteoarthritis
by: Heng Li, et al.
Published: (2017-11-01)

Krüppel-like Factor 2 (KLF2) in Immune Cell Migration
by: Jens Wittner, et al.
Published: (2021-10-01)

Rosmarinic acid induces rabbit articular chondrocyte differentiation by decreases matrix metalloproteinase-13 and inflammation by upregulating cyclooxygenase-2 expression
by: Seong-Hui Eo, et al.
Published: (2017-09-01)

Lunasin abrogates the expression of matrix metalloproteinases and reduction of type II collagen
by: Weihua Dai, et al.
Published: (2019-12-01)

Saxagliptin suppresses degradation of type II collagen and aggrecan in primary human chondrocytes: a therapeutic implication in osteoarthritis
by: Ning Hu, et al.
Published: (2019-12-01)

Expression of metalloproteinases MMP-2 and MMP-9 is associated to the presence of androgen receptor in epithelial ovarian tumors
by: Flavia Morales-Vásquez, et al.
Published: (2020-07-01)

Matrix metalloproteinases (MMP-1, -8, -13) in chronic periapical lesions
by: Andonovska Biljana, et al.
Published: (2008-01-01)

Importance of Metalloproteinase 8 (MMP-8) in the Diagnosis of Periodontitis
by: Emilia Anna Zalewska, et al.
Published: (2024-02-01)

Levels of Selected Matrix Metalloproteinases—MMP-1, MMP-2 and Fibronectin in the Saliva of Patients Planned for Endodontic Treatment or Surgical Extraction
by: Ewa Matuszczak, et al.
Published: (2020-12-01)

Trabecular Bone Parameters, TIMP-2, MMP-8, MMP-13, VEGF Expression and Immunolocalization in Bone and Cartilage in Newborn Offspring Prenatally Exposed to Fumonisins
by: Ewa Tomaszewska, et al.
Published: (2021-11-01)

Design and Synthesis of Water-Soluble and Potent MMP-13 Inhibitors with Activity in Human Osteosarcoma Cells
by: Jose Maria Zapico, et al.
Published: (2021-09-01)

The effect of kaempferol on the dentin bonding stability through matrix metalloproteinases inhibition and collagen crosslink in dentin biomodification
by: Jeonghwa Cho, et al.
Published: (2023-07-01)

Proinflammatory cytokines and lipopolysaccharides up regulate MMP-3 and MMP-13 production in Asian elephant (Elephas maximus) chondrocytes: attenuation by anti-arthritic agents
by: Nutnicha Sirikaew, et al.
Published: (2019-11-01)

GENDER-RELATED DIFFERENCE IN AQUEOUS HUMOR MATRIX METALLOPROTEINASES MMP-2 AND TISSUE INHIBITOR OF MATRIX METALLOPROTEINASES IN PATIENTS WITH PSEUDOEXFOLIATION SYNDROME/GLAUCOMA
by: Gordana Zlatanović, et al.
Published: (2010-03-01)

Role of Matrix Metalloproteinases and Their Inhibitors in Locally Invasive Papillary Thyroid Cancer
by: Irena Ivković, et al.
Published: (2022-12-01)

Potential of a Novel Chemical Compound Targeting Matrix Metalloprotease-13 for Early Osteoarthritis: An In Vitro Study
by: Junko Inagaki, et al.
Published: (2022-02-01)

Integrated Multi-Omics Investigations of Metalloproteinases in Colon Cancer: Focus on MMP2 and MMP9
by: Miriam Buttacavoli, et al.
Published: (2021-11-01)

Dynamic Expression of Membrane Type 1-Matrix Metalloproteinase (Mt1-mmp/Mmp14) in the Mouse Embryo
by: Emma Muñoz-Sáez, et al.
Published: (2021-09-01)

Detection and activity of MMP-2 and MMP-9 in Leishmania amazonensis and Leishmania braziliensis promastigotes
by: Brenda Furtado Costa, et al.
Published: (2023-08-01)

Kruppel-like Factors in Skeletal Physiology and Pathologies
by: Makoto Abe, et al.
Published: (2022-12-01)

Matrix Metalloproteinase Genes (<i>MMP1, MMP10, MMP12</i>) on Chromosome 11q22 and the Risk of Non-Contact Anterior Cruciate Ligament Ruptures
by: Ewelina Lulińska, et al.
Published: (2020-07-01)

The Significance of Matrix Metalloproteinase 9 (MMP-9) and Metalloproteinase 2 (MMP-2) in Urinary Bladder Cancer
by: Jacek Kudelski, et al.
Published: (2023-03-01)

Quercetin prevent proteoglycan destruction by inhibits matrix metalloproteinase-9, matrix metalloproteinase-13, a disintegrin and metalloproteinase with thrombospondin motifs-5 expressions on osteoarthritis model rats
by: Dian Agustina Permatasari, et al.
Published: (2019-01-01)

Molecular function of Krüppel-like factor 7 in biology
by: Mao Yi, et al.
Published: (2023-05-01)

Novel Matrix Metalloproteinase-9 (MMP-9) Inhibitors in Cancer Treatment
by: Zainab Ahmed Rashid, et al.
Published: (2023-07-01)

The Effects of Botulinum Toxin A on Collagen Synthesis, Expression of MMP (matrix metalloproteinases)-1,2,9 and TIMP (tissue inhibitors of metalloproteinase)-1 in the Keloid Fibroblasts
by: Tai Suk Roh, et al.
Published: (2013-06-01)

In silico Study of Some Natural Anthraquinones on Matrix Metalloproteinase Inhibition
by: Amir Taherkhani, et al.
Published: (2021-10-01)

Dexamethasone Attenuates the Expression of MMP-13 in Chondrocytes through MKP-1
by: Tiina Lehtola, et al.
Published: (2022-03-01)

Krüppel-like Factor 9 (KLF9) Suppresses Hepatocellular Carcinoma (HCC)-Promoting Oxidative Stress and Inflammation in Mice Fed High-Fat Diet
by: Adam R. Brown, et al.
Published: (2022-03-01)

Monitoring and Inhibiting MT1-MMP during Cancer Initiation and Progression
by: Sonia Pahwa, et al.
Published: (2014-02-01)

Procyanidins attenuate neuropathic pain by suppressing matrix metalloproteinase-9/2
by: Cailong Pan, et al.
Published: (2018-06-01)

Matrix Metalloproteinase 13 Activity is Required for Normal and Hypoxia-Induced Precocious Hatching in Zebrafish Embryos
by: Christopher D. Small, et al.
Published: (2020-01-01)

Potential Value of Matrix Metalloproteinase-13 as a Biomarker for Osteoarthritis
by: Xing Xin, et al.
Published: (2021-10-01)

The Influence of New Silicate Cement Mineral Trioxide Aggregate (MTA Repair HP) on Metalloproteinase MMP-2 and MMP-9 Expression in Cultured THP-1 Macrophages
by: Katarzyna Barczak, et al.
Published: (2020-12-01)

Bi-directional immuno-modulation by Matrix Metalloproteinase-7 (MMP-7) and A Disintegrin And Metalloproteinase-17 (ADAM-17) as transplantation rejection-tolerance spectrum
by: Robert Chen
Published: (2016-05-01)

Matrix Metalloproteinases in Oral Health—Special Attention on MMP-8
by: Tsvetelina Atanasova, et al.
Published: (2023-05-01)