LTA4H genotype is associated with susceptibility to bacterial meningitis but is not a critical determinant of outcome.
Adjunctive dexamethasone saves lives in the treatment of tuberculous meningitis but this response is influenced by the patient's LTA4H genotype. Despite less certain benefit, adjunctive dexamethasone is also frequently used in the treatment of pyogenic bacterial meningitis, but the influence of...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2015-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4370666?pdf=render |
| _version_ | 1819078477897269248 |
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| author | Sarah J Dunstan Trinh Thi Bich Tram Guy E Thwaites Tran Thi Hong Chau Nguyen Hoan Phu Tran Tinh Hien Jeremy J Farrar Marcel Wolbers Nguyen Thi Hoang Mai |
| author_facet | Sarah J Dunstan Trinh Thi Bich Tram Guy E Thwaites Tran Thi Hong Chau Nguyen Hoan Phu Tran Tinh Hien Jeremy J Farrar Marcel Wolbers Nguyen Thi Hoang Mai |
| author_sort | Sarah J Dunstan |
| collection | DOAJ |
| description | Adjunctive dexamethasone saves lives in the treatment of tuberculous meningitis but this response is influenced by the patient's LTA4H genotype. Despite less certain benefit, adjunctive dexamethasone is also frequently used in the treatment of pyogenic bacterial meningitis, but the influence of LTA4H genotype on outcomes has not been previously investigated. We genotyped the LTA4H promoter region SNP (rs17525495) in 390 bacterial meningitis patients and 751 population controls. rs17525495 was associated with susceptibility to bacteriologically confirmed bacterial meningitis (P = 0.01, OR 1.27 95% confidence interval [CI] 1.05-1.54) but did not influence clinical presentation, disease severity or survival following dexamethasone treatment. |
| first_indexed | 2024-12-21T19:13:43Z |
| format | Article |
| id | doaj.art-a4f9755ca1d24c39864064b6b1e93dfe |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-21T19:13:43Z |
| publishDate | 2015-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-a4f9755ca1d24c39864064b6b1e93dfe2022-12-21T18:53:08ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-01103e011878910.1371/journal.pone.0118789LTA4H genotype is associated with susceptibility to bacterial meningitis but is not a critical determinant of outcome.Sarah J DunstanTrinh Thi Bich TramGuy E ThwaitesTran Thi Hong ChauNguyen Hoan PhuTran Tinh HienJeremy J FarrarMarcel WolbersNguyen Thi Hoang MaiAdjunctive dexamethasone saves lives in the treatment of tuberculous meningitis but this response is influenced by the patient's LTA4H genotype. Despite less certain benefit, adjunctive dexamethasone is also frequently used in the treatment of pyogenic bacterial meningitis, but the influence of LTA4H genotype on outcomes has not been previously investigated. We genotyped the LTA4H promoter region SNP (rs17525495) in 390 bacterial meningitis patients and 751 population controls. rs17525495 was associated with susceptibility to bacteriologically confirmed bacterial meningitis (P = 0.01, OR 1.27 95% confidence interval [CI] 1.05-1.54) but did not influence clinical presentation, disease severity or survival following dexamethasone treatment.http://europepmc.org/articles/PMC4370666?pdf=render |
| spellingShingle | Sarah J Dunstan Trinh Thi Bich Tram Guy E Thwaites Tran Thi Hong Chau Nguyen Hoan Phu Tran Tinh Hien Jeremy J Farrar Marcel Wolbers Nguyen Thi Hoang Mai LTA4H genotype is associated with susceptibility to bacterial meningitis but is not a critical determinant of outcome. PLoS ONE |
| title | LTA4H genotype is associated with susceptibility to bacterial meningitis but is not a critical determinant of outcome. |
| title_full | LTA4H genotype is associated with susceptibility to bacterial meningitis but is not a critical determinant of outcome. |
| title_fullStr | LTA4H genotype is associated with susceptibility to bacterial meningitis but is not a critical determinant of outcome. |
| title_full_unstemmed | LTA4H genotype is associated with susceptibility to bacterial meningitis but is not a critical determinant of outcome. |
| title_short | LTA4H genotype is associated with susceptibility to bacterial meningitis but is not a critical determinant of outcome. |
| title_sort | lta4h genotype is associated with susceptibility to bacterial meningitis but is not a critical determinant of outcome |
| url | http://europepmc.org/articles/PMC4370666?pdf=render |
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