CTAB functionalized multiwalled carbon nanotube composite modified electrode for the determination of 6-mercaptopurine
In this work the electrochemical behavior of 6-mercaptopurine (6-MP) on MWCNT-CTAB modified glassy carbon electrode (GCE) is reported in a phosphate buffer solution, pH 3.0. Cyclic voltammetric studies indicated that the oxidation process is irreversible and diffusion-controlled. The number of elect...
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| Format: | Article |
| Language: | English |
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Elsevier
2017-02-01
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| Series: | Sensing and Bio-Sensing Research |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214180416300964 |
| _version_ | 1831756657003069440 |
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| author | Jayant I. Gowda Mallappa M. Sharanappa T. Nandibewoor |
| author_facet | Jayant I. Gowda Mallappa M. Sharanappa T. Nandibewoor |
| author_sort | Jayant I. Gowda |
| collection | DOAJ |
| description | In this work the electrochemical behavior of 6-mercaptopurine (6-MP) on MWCNT-CTAB modified glassy carbon electrode (GCE) is reported in a phosphate buffer solution, pH 3.0. Cyclic voltammetric studies indicated that the oxidation process is irreversible and diffusion-controlled. The number of electrons exchanged in the electro-oxidation process was obtained, and the data indicated that 6-MP is oxidized via a two-electron step. The results revealed that MWCNT-CTAB modified GCE promotes the rate of oxidation compared to the bare GCE, by increasing the peak current. The electron-transfer coefficients and heterogeneous electron-transfer rate constants for 6-MP were reported using modified GCE. A sensitive, simple, and timesaving linear sweep voltammetric procedure was developed for the analysis of 6-MP, using the MWCNT-CTAB/GC electrode. 6-MP can be determined with a detection limit of 8.41 × 10−9 M in the range of 5.0 × 10−7 M to 3.0 × 10−6 M with the proposed method. The developed method was successfully applied in real sample analysis. Keywords: Electrochemical method, 6-Mercaptopurine, Modified electrode, Detection limit, Calibration |
| first_indexed | 2024-12-22T00:16:47Z |
| format | Article |
| id | doaj.art-a4fd4d77647c49e0a08a5c273a1b67ba |
| institution | Directory Open Access Journal |
| issn | 2214-1804 |
| language | English |
| last_indexed | 2024-12-22T00:16:47Z |
| publishDate | 2017-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Sensing and Bio-Sensing Research |
| spelling | doaj.art-a4fd4d77647c49e0a08a5c273a1b67ba2022-12-21T18:45:16ZengElsevierSensing and Bio-Sensing Research2214-18042017-02-011217CTAB functionalized multiwalled carbon nanotube composite modified electrode for the determination of 6-mercaptopurineJayant I. Gowda0Mallappa M.1Sharanappa T. Nandibewoor2P.G. Department of Chemistry, P.C. Jabin Science College, Hubballi 580 031, India; Corresponding author.Department of Chemistry, Maharani's Science College for Women, Bangalore 560 001, IndiaP.G. Department of Studies in Chemistry, Karnatak University, Dharwad 580 003, IndiaIn this work the electrochemical behavior of 6-mercaptopurine (6-MP) on MWCNT-CTAB modified glassy carbon electrode (GCE) is reported in a phosphate buffer solution, pH 3.0. Cyclic voltammetric studies indicated that the oxidation process is irreversible and diffusion-controlled. The number of electrons exchanged in the electro-oxidation process was obtained, and the data indicated that 6-MP is oxidized via a two-electron step. The results revealed that MWCNT-CTAB modified GCE promotes the rate of oxidation compared to the bare GCE, by increasing the peak current. The electron-transfer coefficients and heterogeneous electron-transfer rate constants for 6-MP were reported using modified GCE. A sensitive, simple, and timesaving linear sweep voltammetric procedure was developed for the analysis of 6-MP, using the MWCNT-CTAB/GC electrode. 6-MP can be determined with a detection limit of 8.41 × 10−9 M in the range of 5.0 × 10−7 M to 3.0 × 10−6 M with the proposed method. The developed method was successfully applied in real sample analysis. Keywords: Electrochemical method, 6-Mercaptopurine, Modified electrode, Detection limit, Calibrationhttp://www.sciencedirect.com/science/article/pii/S2214180416300964 |
| spellingShingle | Jayant I. Gowda Mallappa M. Sharanappa T. Nandibewoor CTAB functionalized multiwalled carbon nanotube composite modified electrode for the determination of 6-mercaptopurine Sensing and Bio-Sensing Research |
| title | CTAB functionalized multiwalled carbon nanotube composite modified electrode for the determination of 6-mercaptopurine |
| title_full | CTAB functionalized multiwalled carbon nanotube composite modified electrode for the determination of 6-mercaptopurine |
| title_fullStr | CTAB functionalized multiwalled carbon nanotube composite modified electrode for the determination of 6-mercaptopurine |
| title_full_unstemmed | CTAB functionalized multiwalled carbon nanotube composite modified electrode for the determination of 6-mercaptopurine |
| title_short | CTAB functionalized multiwalled carbon nanotube composite modified electrode for the determination of 6-mercaptopurine |
| title_sort | ctab functionalized multiwalled carbon nanotube composite modified electrode for the determination of 6 mercaptopurine |
| url | http://www.sciencedirect.com/science/article/pii/S2214180416300964 |
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