A Therapeutically Active Minibody Exhibits an Antiviral Activity in Oseltamivir-Resistant Influenza-Infected Mice via Direct Hydrolysis of Viral RNAs

A Therapeutically Active Minibody Exhibits an Antiviral Activity in Oseltamivir-Resistant Influenza-Infected Mice via Direct Hydrolysis of Viral RNAs

Emerging Oseltamivir-resistant influenza strains pose a critical public health threat due to antigenic shifts and drifts. We report an innovative strategy for controlling influenza A infections by use of a novel minibody of the 3D8 single chain variable fragment (scFv) showing intrinsic viral RNA hy...

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Bibliographic Details
Main Authors: Yongjun Lee, Phuong Thi Hoang, Dongjun Kim, Ramadhani Qurrota Ayun, Quynh Xuan Thi Luong, Kyungho Na, Taehyun Kim, Yeonsu Oh, Won-Keun Kim, Sukchan Lee
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Viruses
Subjects:
H1N1/H275Y
3D8 scFv
antivirus
prophylactic effect
therapeutic effect
Online Access:https://www.mdpi.com/1999-4915/14/5/1105

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