Effective asymmetric preparation of (R)-1-[3-(trifluoromethyl)phenyl]ethanol with recombinant E. coli whole cells in an aqueous Tween-20/natural deep eutectic solvent solution

Effective asymmetric preparation of (R)-1-[3-(trifluoromethyl)phenyl]ethanol with recombinant E. coli whole cells in an aqueous Tween-20/natural deep eutectic solvent solution

Abstract (R)-1-[3-(Trifluoromethyl)phenyl]ethanol ((R)-MTF-PEL) is an important chiral building block for the synthesis of a neuroprotective compound, (R)-3-(1-(3-(trifluoromethyl)phenyl)ethoxy)azetidine-1-carboxamide. In this work, an effective whole-cell-catalyzed biotransformation was developed t...

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Bibliographic Details
Main Authors: Wenjin Zhuang, Hanyu Liu, Ying Zhang, Junyao He, Pu Wang
Format: Article
Language:English
Published: SpringerOpen 2021-08-01
Series:AMB Express
Subjects:
Biotransformation
Whole-cell catalysis
Surfactant
Natural deep eutectic solvent
Chiral alcohol
Online Access:https://doi.org/10.1186/s13568-021-01278-6

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