Exploring New Potential Anticancer Activities of the G-Quadruplexes Formed by [(GTG<sub>2</sub>T(G<sub>3</sub>T)<sub>3</sub>] and Its Derivatives with an Abasic Site Replacing Single Thymidine

Exploring New Potential Anticancer Activities of the G-Quadruplexes Formed by [(GTG<sub>2</sub>T(G<sub>3</sub>T)<sub>3</sub>] and Its Derivatives with an Abasic Site Replacing Single Thymidine

In this paper, we report our investigations on five T30175 analogues, prepared by replacing sequence thymidines with abasic sites (S) one at a time, in comparison to their natural counterpart in order to evaluate their antiproliferative potential and the involvement of the residues not belonging to...

Full description

Bibliographic Details
Main Authors:	Antonella Virgilio, Daniela Benigno, Annalisa Pecoraro, Annapina Russo, Giulia Russo, Veronica Esposito, Aldo Galeone
Format:	Article
Language:	English
Published:	MDPI AG 2021-06-01
Series:	International Journal of Molecular Sciences
Subjects:	G-quadruplex abasic site aptamers antiproliferative activity
Online Access:	https://www.mdpi.com/1422-0067/22/13/7040

Similar Items

Antiproliferative Effects of the Aptamer d(GGGT)<sub>4</sub> and Its Analogues with an Abasic-Site Mimic Loop on Different Cancer Cells
by: Antonella Virgilio, et al.
Published: (2022-05-01)

Properties and Potential Antiproliferative Activity of Thrombin-Binding Aptamer (TBA) Derivatives with One or Two Additional G-Tetrads
by: Daniela Benigno, et al.
Published: (2022-11-01)

uL3 Mediated Nucleolar Stress Pathway as a New Mechanism of Action of Antiproliferative G-quadruplex TBA Derivatives in Colon Cancer Cells
by: Annalisa Pecoraro, et al.
Published: (2020-04-01)

Thermally Induced Transitions of d(G<sub>4</sub>T<sub>4</sub>G<sub>3</sub>) Quadruplexes Can Be Described as Kinetically Driven Processes
by: Iztok Prislan, et al.
Published: (2022-06-01)

Effects of Length and Loop Composition on Structural Diversity and Similarity of (G<sub>3</sub>TG<sub>3</sub>N<sub>m</sub>G<sub>3</sub>TG<sub>3</sub>) G-Quadruplexes
by: Jie Li, et al.
Published: (2020-04-01)

Structural and Biological Features of G-Quadruplex Aptamers as Promising Inhibitors of the STAT3 Signaling Pathway
by: Veronica Esposito, et al.
Published: (2023-05-01)

Intensive Distribution of G<sub>2</sub>-Quaduplexes in the Pseudorabies Virus Genome and Their Sensitivity to Cations and G-Quadruplex Ligands
by: Hui Deng, et al.
Published: (2019-02-01)

Analysis of large deletion mutations induced by abasic site analog in human cells
by: Tetsuya Suzuki, et al.
Published: (2018-10-01)

G-Quadruplex Aptamer-Ligand Characterization
by: David Moreira, et al.
Published: (2022-10-01)

Probing the Importance of the G-Quadruplex Grooves for the Activity of the Anti-HIV-Integrase Aptamer T30923
by: Veronica Esposito, et al.
Published: (2020-08-01)

Supramolecular Polymorphism of (G<sub>4</sub>C<sub>2</sub>)<sub>n</sub> Repeats Associated with ALS and FTD
by: Melani Potrč, et al.
Published: (2021-04-01)

Beyond G-Quadruplexes—The Effect of Junction with Additional Structural Motifs on Aptamers Properties
by: Weronika Kotkowiak, et al.
Published: (2021-09-01)

Impact of a Single Nucleotide Change or Non-Nucleoside Modifications in G-Rich Region on the Quadruplex–Duplex Hybrid Formation
by: Dorota Gudanis, et al.
Published: (2021-08-01)

The Interactions of H<sub>2</sub>TMPyP, Analogues and Its Metal Complexes with DNA G-Quadruplexes—An Overview
by: Catarina I. V. Ramos, et al.
Published: (2021-09-01)

G-Quadruplex Forming Oligonucleotides as Anti-HIV Agents
by: Domenica Musumeci, et al.
Published: (2015-09-01)

G-Quadruplexes Formation by the <i>C9orf72</i> Nucleotide Repeat Expansion d(GGGGCC)<sub>n</sub> and Conformation Regulation by Fangchinoline
by: Yun Zhang, et al.
Published: (2023-06-01)

G-QINDER Tool: Bioinformatically Predicted Formation of Different Four-Stranded DNA Motifs from (GT)<sub>n</sub> and (GA)<sub>n</sub> Repeats
by: Lukáš Trizna, et al.
Published: (2023-04-01)

Spectroscopic Properties of Two 5′-(4-Dimethylamino)Azobenzene Conjugated G-Quadruplex Forming Oligonucleotides
by: Concetta Imperatore, et al.
Published: (2020-09-01)

Aptamers Against the β-Conglutin Allergen: Insights into the Behavior of the Shortest Multimeric(Intra)Molecular DNA G-Quadruplex
by: Ciara K. O’ Sullivan, et al.
Published: (2021-01-01)

G4 Matters—The Influence of G-Quadruplex Structural Elements on the Antiproliferative Properties of G-Rich Oligonucleotides
by: Carolina Roxo, et al.
Published: (2021-05-01)

Development of Mn<sup>2+</sup>-Specific Biosensor Using G-Quadruplex-Based DNA
by: Masataka Mizunuma, et al.
Published: (2023-07-01)

A Fluorescent Aptasensor Based on Assembled G-Quadruplex and Thioflavin T for the Detection of Biomarker VEGF165
by: Xin Zheng, et al.
Published: (2021-11-01)

Bimodular Antiparallel G-Quadruplex Nanoconstruct with Antiproliferative Activity
by: Olga Antipova, et al.
Published: (2019-10-01)

Construction of Aptamer-Based Nanobiosensor for Breast Cancer Biomarkers Detection Utilizing g-C<sub>3</sub>N<sub>4</sub>/Magnetic Nano-Structure
by: Mehrab Pourmadadi, et al.
Published: (2022-10-01)

Non-Modified CpG Oligodeoxynucleotide Forming Guanine-Quadruplex Structure Complexes with ε-Poly-<sub>L</sub>-Lysine Induce Antibody Production as Vaccine Adjuvants
by: Dandan Zhao, et al.
Published: (2022-12-01)

Photocatalytic Duplex-Based DNAzymes Switched by an Abasic Site
by: Longlong Gao, et al.
Published: (2023-06-01)

G-Quadruplex-Based Fluorescent Turn-On Ligands and Aptamers: From Development to Applications
by: Mubarak I. Umar, et al.
Published: (2019-06-01)

Discovering New G-Quadruplex DNA Catalysts in Enantioselective Sulfoxidation Reaction
by: Carmen Festa, et al.
Published: (2022-01-01)

G-Quadruplex-Forming Aptamers—Characteristics, Applications, and Perspectives
by: Carolina Roxo, et al.
Published: (2019-10-01)

Spectroscopic Characterization of Mitochondrial G-Quadruplexes
by: Sara Illodo, et al.
Published: (2022-01-01)

Short Duplex Module Coupled to G-Quadruplexes Increases Fluorescence of Synthetic GFP Chromophore Analogues
by: Snizhana O. Zaitseva, et al.
Published: (2020-02-01)

Data on G-quadruplex topology, and binding ability of G-quadruplex forming sequences found in the promoter region of biomarker proteins and those relations to the presence of nuclear localization signal in the proteins
by: Jinhee Lee, et al.
Published: (2021-06-01)

Synthesis and Characterization of Abasic β-Diol-<i>C</i>-nucleosides
by: Maria Moccia, et al.
Published: (2023-05-01)

An Electrochemical Ti<sub>3</sub>C<sub>2</sub>T<sub>x</sub> Aptasensor for Sensitive and Label-Free Detection of Marine Biological Toxins
by: Najeeb Ullah, et al.
Published: (2021-07-01)

Recent Progress and Development of G-Quadruplex-Based Luminescent Assays for Ochratoxin A Detection
by: Sang-Cuo Nao, et al.
Published: (2020-09-01)

Searching for G-Quadruplex-Binding Proteins in Plants: New Insight into Possible G-Quadruplex Regulation
by: Adriana Volná, et al.
Published: (2021-09-01)

Sensitive Electrochemical Detection of Tryptophan Using a Hemin/G-Quadruplex Aptasensor
by: Ayemeh Bagheri Hashkavayi, et al.
Published: (2020-10-01)

Identification of G-quadruplex anti-Interleukin-2 aptamer with high specificity through SELEX stringency
by: Mohsen Momeni, et al.
Published: (2022-06-01)

G-Quadruplexes in Human Telomere: Structures, Properties, and Applications
by: Yan Xu, et al.
Published: (2023-12-01)

Exploring the Interaction of New Pyridoquinazoline Derivatives with G-Quadruplex in the c-MYC Promoter Region
by: Salvatore Princiotto, et al.
Published: (2023-09-01)