TRPV3: Structure, Diseases and Modulators

TRPV3: Structure, Diseases and Modulators

Transient receptor potential vanillin 3 (TRPV3) is a member of the transient receptor potential (TRP) superfamily. As a Ca<sup>2+</sup>-permeable nonselective cation channel, TRPV3 can recognize thermal stimulation (31–39 °C), and it plays an important regulatory role in temperature perc...

Full description

Bibliographic Details
Main Authors:	Wuyue Su, Xue Qiao, Wumei Wang, Shengnan He, Ke Liang, Xuechuan Hong
Format:	Article
Language:	English
Published:	MDPI AG 2023-01-01
Series:	Molecules
Subjects:	TRPV3 structure diseases agonists antagonists
Online Access:	https://www.mdpi.com/1420-3049/28/2/774

Similar Items

Impact of TRPV1 on Pathogenesis and Therapy of Neurodegenerative Diseases
by: Wenxin Wang, et al.
Published: (2023-12-01)

Transient Receptor Potential Vanilloid (TRPV4) channel inhibition: A novel promising approach for the treatment of lung diseases
by: Mohit Kumar, et al.
Published: (2023-07-01)

In Silico Drug Repurposing Framework Predicts Repaglinide, Agomelatine and Protokylol as TRPV1 Modulators with Analgesic Activity
by: Corina Andrei, et al.
Published: (2022-11-01)

TRPV1: Structure, Endogenous Agonists, and Mechanisms
by: Miguel Benítez-Angeles, et al.
Published: (2020-05-01)

New capsaicin analogs as molecular rulers to define the permissive conformation of the mouse TRPV1 ligand-binding pocket
by: Simon Vu, et al.
Published: (2020-11-01)

Intracellular Helix-Loop-Helix Domain Modulates Inactivation Kinetics of Mammalian TRPV5 and TRPV6 Channels
by: Lisandra Flores-Aldama, et al.
Published: (2023-02-01)

Expression Profiling of the Transient Receptor Potential Vanilloid (TRPV) Channels 1, 2, 3 and 4 in Mucosal Epithelium of Human Ulcerative Colitis
by: Theodoros Rizopoulos, et al.
Published: (2018-06-01)

Cannabidiol sensitizes TRPV2 channels to activation by 2-APB
by: Aaron Gochman, et al.
Published: (2023-05-01)

Quantitative Predictive Studies of Multiple Biological Activities of TRPV1 Modulators
by: Xinmiao Wei, et al.
Published: (2024-01-01)

Urothelial TRPV1: TRPV1-reporter mice, a way to clarify the debate?
by: Mathieu eBoudes, et al.
Published: (2012-05-01)

Computational Modeling to Explain Why 5,5-Diarylpentadienamides are TRPV1 Antagonists
by: Julio Caballero
Published: (2021-03-01)

TRPV4: A Physio and Pathophysiologically Significant Ion Channel
by: Tamara Rosenbaum, et al.
Published: (2020-05-01)

Mechanical Stretch Activates TRPV4 and Hemichannel Responses in the Nonpigmented Ciliary Epithelium
by: Mohammad Shahidullah, et al.
Published: (2023-01-01)

The Role of C Fibers in Spinal Microglia Induction and Possible Relation with TRPV3 Expression During Chronic Inflammatory Arthritis in Rats
by: Sasan Gazerani, et al.
Published: (2016-07-01)

Receptor modulators associated with the hypothalamus -pituitary-thyroid axis
by: Xianbin Cheng, et al.
Published: (2023-12-01)

TRPV1 Channel in Human Eosinophils: Functional Expression and Inflammatory Modulation
by: Tobias Weihrauch, et al.
Published: (2024-02-01)

TRPM8 Channels: Advances in Structural Studies and Pharmacological Modulation
by: Carolina Izquierdo, et al.
Published: (2021-08-01)

TRPV3 Ion Channel: From Gene to Pharmacology
by: Aleksandr P. Kalinovskii, et al.
Published: (2023-05-01)

Scalable Synthesis of TRPV1 Antagonist Bipyridinyl Benzimidazole Derivative via the Suzuki–Miyaura Reaction and Selective SeO<sub>2</sub> Oxidation
by: Joon-Hwan Lee, et al.
Published: (2023-01-01)

Anti-Inflammatory and Analgesic Effects of TRPV1 Polypeptide Modulator APHC3 in Models of Osteo- and Rheumatoid Arthritis
by: Yulia A. Logashina, et al.
Published: (2021-01-01)

CRISPR Deletion of a SVA Retrotransposon Demonstrates Function as a <i>cis</i>-Regulatory Element at the <i>TRPV1/TRPV3</i> Intergenic Region
by: Emma Price, et al.
Published: (2021-02-01)

TRPV Protein Family—From Mechanosensing to Cancer Invasion
by: Tytti Kärki, et al.
Published: (2021-07-01)

TRPV1 Antagonist DWP05195 Induces ER Stress-Dependent Apoptosis through the ROS-p38-CHOP Pathway in Human Ovarian Cancer Cells
by: Yi-Yue Wang, et al.
Published: (2020-06-01)

Lipid Nanoparticle Inclusion Prevents Capsaicin-Induced TRPV1 Defunctionalization
by: Carmelo Puglia, et al.
Published: (2020-04-01)

Pathophysiological Roles of the TRPV4 Channel in the Heart
by: Sébastien Chaigne, et al.
Published: (2023-06-01)

Three-Dimensional Structural Insights Have Revealed the Distinct Binding Interactions of Agonists, Partial Agonists, and Antagonists with the µ Opioid Receptor
by: Zoe Li, et al.
Published: (2023-04-01)

Whole genome sequencing analysis of alpaca suggests TRPV3 as a candidate gene for the suri phenotype
by: Stefano Pallotti, et al.
Published: (2024-02-01)

Modulating TRPV4 Channel Activity in Pro-Inflammatory Macrophages within the 3D Tissue Analog
by: Parto Babaniamansour, et al.
Published: (2024-01-01)

Vitexin inhibits pain and itch behavior via modulating TRPV4 activity in mice
by: Zhiqiang Qin, et al.
Published: (2023-09-01)

Role and Modulation of TRPV1 in Mammalian Spermatozoa: An Updated Review
by: Marina Ramal-Sanchez, et al.
Published: (2021-04-01)

Alpha-Mangostin: A Potent Inhibitor of TRPV3 and Pro-Inflammatory Cytokine Secretion in Keratinocytes
by: Thi Huyen Dang, et al.
Published: (2023-08-01)

TRPV1 Gates Tissue Access and Sustains Pathogenicity in Autoimmune Encephalitis
by: Geoffrey Paltser, et al.
Published: (2013-05-01)

Novel Insights into the Role of Keratinocytes-Expressed TRPV3 in the Skin
by: Yaotao Guo, et al.
Published: (2023-03-01)

Radiofrequency Irradiation Modulates TRPV1-Related Burning Sensation in Rosacea
by: Seyeon Oh, et al.
Published: (2021-03-01)

MicroRNA-369 attenuates hypoxia-induced cardiomyocyte apoptosis and inflammation via targeting TRPV3
by: Jinghao Wang, et al.
Published: (2021-01-01)

TRPV1 Contributes to Modulate the Nitric Oxide Pathway and Oxidative Stress in the Isolated and Perfused Rat Heart during Ischemia and Reperfusion
by: Vicente Castrejón-Téllez, et al.
Published: (2022-02-01)

Capsaicin and TRPV1 Channels in the Cardiovascular System: The Role of Inflammation
by: Sreepadaarchana Munjuluri, et al.
Published: (2021-12-01)

TRPC and TRPV Channels’ Role in Vascular Remodeling and Disease
by: Marta Martín-Bórnez, et al.
Published: (2020-08-01)

Structure-based characterization of novel TRPV5 inhibitors
by: Taylor ET Hughes, et al.
Published: (2019-10-01)

Physiological levels of fluid shear stress modulate vascular function through TRPV4 sparklets
by: Geng Li, et al.
Published: (2022-09-01)