Extracellular Loops of the Treponema pallidum FadL Orthologs TP0856 and TP0858 Elicit IgG Antibodies and IgG+-Specific B-Cells in the Rabbit Model of Experimental Syphilis

Extracellular Loops of the Treponema pallidum FadL Orthologs TP0856 and TP0858 Elicit IgG Antibodies and IgG+-Specific B-Cells in the Rabbit Model of Experimental Syphilis

ABSTRACT The resurgence of syphilis in the new millennium has called attention to the importance of a vaccine for global containment strategies. Studies with immune rabbit serum (IRS) indicate that a syphilis vaccine should elicit antibodies (Abs) that promote opsonophagocytosis of treponemes by act...

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Bibliographic Details
Main Authors: Kristina N. Delgado, Jairo M. Montezuma-Rusca, Isabel C. Orbe, Melissa J. Caimano, Carson J. La Vake, Amit Luthra, Christopher M. Hennelly, Fredrick N. Nindo, Jacob W. Meyer, Letitia D. Jones, Jonathan B. Parr, Juan C. Salazar, M. Anthony Moody, Justin D. Radolf, Kelly L. Hawley
Format: Article
Language:English
Published: American Society for Microbiology 2022-08-01
Series:mBio
Subjects:
Treponema pallidum
syphilis
outer membrane protein
extracellular loop
FadL
B cells
Online Access:https://journals.asm.org/doi/10.1128/mbio.01639-22

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