The association between skin auto-fluorescence of palmoplantar sites and microvascular complications in Asian patients with type 2 diabetes mellitus
Abstract Skin auto-fluorescence (SAF) has generated broad interest about the prospects for non-invasive advanced glycation end product assessment and its direct interplay with the development of microvascular complications, but clinical application of the existing SAF measuring of non-palmoplantar s...
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| Format: | Article |
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Nature Portfolio
2018-04-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-018-24707-2 |
| _version_ | 1818998753935228928 |
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| author | Jong Jin Kim Bosu Jeong Yongin Cho Mi-hyang Kwon Yong-ho Lee Uk Kang Eun Seok Kang |
| author_facet | Jong Jin Kim Bosu Jeong Yongin Cho Mi-hyang Kwon Yong-ho Lee Uk Kang Eun Seok Kang |
| author_sort | Jong Jin Kim |
| collection | DOAJ |
| description | Abstract Skin auto-fluorescence (SAF) has generated broad interest about the prospects for non-invasive advanced glycation end product assessment and its direct interplay with the development of microvascular complications, but clinical application of the existing SAF measuring of non-palmoplantar sites in non-Caucasian subjects with dark skin type is still controversial. Here, we tested the diabetic complication screening performance of a novel SAF measuring system in Asian type 2 diabetes mellitus (T2DM) subjects. A total of 166 Korean patients with T2DM were enrolled in this study and palmoplantar SAF was measured by a newly developed transmission-geometry noninvasive optical system. We found that transmitted SAF values of palmoplantar sites, 1st dorsal interossei muscles of the hand, in a complication group were significantly higher than in a non-complication group while no differences were observed between the two groups in reflected SAF of non-palmoplantar sites. The transmitted SAF values of palmoplantar sites were dramatically increased in subjects with multiple complications and were tightly correlated with the duration of microvascular complications. In conclusion, the SAF measurement in the palmoplantar sites with a non-invasive transmission-geometry optical system provided better microvascular complication screening performance compared to the SAF measurement of non-palmoplantar sites specifically in Asian T2DM subjects. |
| first_indexed | 2024-12-20T22:06:33Z |
| format | Article |
| id | doaj.art-a502e173f42040f4aa81c1de1d60b82f |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-20T22:06:33Z |
| publishDate | 2018-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-a502e173f42040f4aa81c1de1d60b82f2022-12-21T19:25:15ZengNature PortfolioScientific Reports2045-23222018-04-01811710.1038/s41598-018-24707-2The association between skin auto-fluorescence of palmoplantar sites and microvascular complications in Asian patients with type 2 diabetes mellitusJong Jin Kim0Bosu Jeong1Yongin Cho2Mi-hyang Kwon3Yong-ho Lee4Uk Kang5Eun Seok Kang6Russia Science Seoul Center, Advanced Medical Device Research Division, Korea Electrotechnology Research InstituteRussia Science Seoul Center, Advanced Medical Device Research Division, Korea Electrotechnology Research InstituteDivision of Endocrinology and Metabolism, Department of Internal Medicine, Yonsei University College of MedicineDivision of Endocrinology and Metabolism, Department of Internal Medicine, Yonsei University College of MedicineDivision of Endocrinology and Metabolism, Department of Internal Medicine, Yonsei University College of MedicineRussia Science Seoul Center, Advanced Medical Device Research Division, Korea Electrotechnology Research InstituteDivision of Endocrinology and Metabolism, Department of Internal Medicine, Yonsei University College of MedicineAbstract Skin auto-fluorescence (SAF) has generated broad interest about the prospects for non-invasive advanced glycation end product assessment and its direct interplay with the development of microvascular complications, but clinical application of the existing SAF measuring of non-palmoplantar sites in non-Caucasian subjects with dark skin type is still controversial. Here, we tested the diabetic complication screening performance of a novel SAF measuring system in Asian type 2 diabetes mellitus (T2DM) subjects. A total of 166 Korean patients with T2DM were enrolled in this study and palmoplantar SAF was measured by a newly developed transmission-geometry noninvasive optical system. We found that transmitted SAF values of palmoplantar sites, 1st dorsal interossei muscles of the hand, in a complication group were significantly higher than in a non-complication group while no differences were observed between the two groups in reflected SAF of non-palmoplantar sites. The transmitted SAF values of palmoplantar sites were dramatically increased in subjects with multiple complications and were tightly correlated with the duration of microvascular complications. In conclusion, the SAF measurement in the palmoplantar sites with a non-invasive transmission-geometry optical system provided better microvascular complication screening performance compared to the SAF measurement of non-palmoplantar sites specifically in Asian T2DM subjects.https://doi.org/10.1038/s41598-018-24707-2 |
| spellingShingle | Jong Jin Kim Bosu Jeong Yongin Cho Mi-hyang Kwon Yong-ho Lee Uk Kang Eun Seok Kang The association between skin auto-fluorescence of palmoplantar sites and microvascular complications in Asian patients with type 2 diabetes mellitus Scientific Reports |
| title | The association between skin auto-fluorescence of palmoplantar sites and microvascular complications in Asian patients with type 2 diabetes mellitus |
| title_full | The association between skin auto-fluorescence of palmoplantar sites and microvascular complications in Asian patients with type 2 diabetes mellitus |
| title_fullStr | The association between skin auto-fluorescence of palmoplantar sites and microvascular complications in Asian patients with type 2 diabetes mellitus |
| title_full_unstemmed | The association between skin auto-fluorescence of palmoplantar sites and microvascular complications in Asian patients with type 2 diabetes mellitus |
| title_short | The association between skin auto-fluorescence of palmoplantar sites and microvascular complications in Asian patients with type 2 diabetes mellitus |
| title_sort | association between skin auto fluorescence of palmoplantar sites and microvascular complications in asian patients with type 2 diabetes mellitus |
| url | https://doi.org/10.1038/s41598-018-24707-2 |
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