Enhancement of natural killer cell cytotoxicity by sodium/iodide symporter gene-mediated radioiodine pretreatment in breast cancer cells.
A phase II study of NK cell therapy in treatment of patients with recurrent breast cancer has recently been reported. However, because of the complexities of tumor microenvironments, effective therapeutic effects have not been achieved in NK cell therapy. Radioiodine (I-131) therapy inhibits cancer...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3734030?pdf=render |
| _version_ | 1818300983196778496 |
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| author | Hae Won Kim Jung Eun Kim Mi-Hye Hwang Yong Hyun Jeon Sang-Woo Lee Jaetae Lee Seok Kil Zeon Byeong-Cheol Ahn |
| author_facet | Hae Won Kim Jung Eun Kim Mi-Hye Hwang Yong Hyun Jeon Sang-Woo Lee Jaetae Lee Seok Kil Zeon Byeong-Cheol Ahn |
| author_sort | Hae Won Kim |
| collection | DOAJ |
| description | A phase II study of NK cell therapy in treatment of patients with recurrent breast cancer has recently been reported. However, because of the complexities of tumor microenvironments, effective therapeutic effects have not been achieved in NK cell therapy. Radioiodine (I-131) therapy inhibits cancer growth by inducing the apoptosis and necrosis of cancer cells. Furthermore, it can modify cancer cell phenotypes and enhance the effect of immunotherapy against cancer cells. The present study showed that I-131 therapy can modulate microenvironment of breast cancer and improve the therapeutic effect by enhancing NK cell cytotoxicity to the tumor cells. The susceptibility of breast cancer cells to NK cell was increased by precedent I-131 treatment in vitro. Tumor burden in mice treated with I-131 plus NK cell was significantly lower than that in mice treated with NK cell or I-131 alone. The up-regulation of Fas, DR5 and MIC A/B on irradiated tumor cells could be the explanation for the enhancement of NK cell cytotoxicity to tumor cells. It can be applied to breast cancer patients with iodine avid metastatic lesions that are non-responsive to conventional treatments. |
| first_indexed | 2024-12-13T05:15:47Z |
| format | Article |
| id | doaj.art-a503c7aeac8f454184486485f544008a |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-13T05:15:47Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-a503c7aeac8f454184486485f544008a2022-12-21T23:58:26ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0188e7019410.1371/journal.pone.0070194Enhancement of natural killer cell cytotoxicity by sodium/iodide symporter gene-mediated radioiodine pretreatment in breast cancer cells.Hae Won KimJung Eun KimMi-Hye HwangYong Hyun JeonSang-Woo LeeJaetae LeeSeok Kil ZeonByeong-Cheol AhnA phase II study of NK cell therapy in treatment of patients with recurrent breast cancer has recently been reported. However, because of the complexities of tumor microenvironments, effective therapeutic effects have not been achieved in NK cell therapy. Radioiodine (I-131) therapy inhibits cancer growth by inducing the apoptosis and necrosis of cancer cells. Furthermore, it can modify cancer cell phenotypes and enhance the effect of immunotherapy against cancer cells. The present study showed that I-131 therapy can modulate microenvironment of breast cancer and improve the therapeutic effect by enhancing NK cell cytotoxicity to the tumor cells. The susceptibility of breast cancer cells to NK cell was increased by precedent I-131 treatment in vitro. Tumor burden in mice treated with I-131 plus NK cell was significantly lower than that in mice treated with NK cell or I-131 alone. The up-regulation of Fas, DR5 and MIC A/B on irradiated tumor cells could be the explanation for the enhancement of NK cell cytotoxicity to tumor cells. It can be applied to breast cancer patients with iodine avid metastatic lesions that are non-responsive to conventional treatments.http://europepmc.org/articles/PMC3734030?pdf=render |
| spellingShingle | Hae Won Kim Jung Eun Kim Mi-Hye Hwang Yong Hyun Jeon Sang-Woo Lee Jaetae Lee Seok Kil Zeon Byeong-Cheol Ahn Enhancement of natural killer cell cytotoxicity by sodium/iodide symporter gene-mediated radioiodine pretreatment in breast cancer cells. PLoS ONE |
| title | Enhancement of natural killer cell cytotoxicity by sodium/iodide symporter gene-mediated radioiodine pretreatment in breast cancer cells. |
| title_full | Enhancement of natural killer cell cytotoxicity by sodium/iodide symporter gene-mediated radioiodine pretreatment in breast cancer cells. |
| title_fullStr | Enhancement of natural killer cell cytotoxicity by sodium/iodide symporter gene-mediated radioiodine pretreatment in breast cancer cells. |
| title_full_unstemmed | Enhancement of natural killer cell cytotoxicity by sodium/iodide symporter gene-mediated radioiodine pretreatment in breast cancer cells. |
| title_short | Enhancement of natural killer cell cytotoxicity by sodium/iodide symporter gene-mediated radioiodine pretreatment in breast cancer cells. |
| title_sort | enhancement of natural killer cell cytotoxicity by sodium iodide symporter gene mediated radioiodine pretreatment in breast cancer cells |
| url | http://europepmc.org/articles/PMC3734030?pdf=render |
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