The biochemical and metabolic profiles of dairy cows with mycotoxins-contaminated diets
Background Previous studies on the effects of mycotoxins have solely focused on their biochemical profiles or products in dairy ruminants. Changes in metabolism that occur after exposure to mycotoxins, as well as biochemical changes, have not been explored. Methods We measured the biochemical and me...
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PeerJ Inc.
2020-03-01
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| Online Access: | https://peerj.com/articles/8742.pdf |
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| author | Qian Wang Yangdong Zhang Nan Zheng Shengguo Zhao Songli Li Jiaqi Wang |
| author_facet | Qian Wang Yangdong Zhang Nan Zheng Shengguo Zhao Songli Li Jiaqi Wang |
| author_sort | Qian Wang |
| collection | DOAJ |
| description | Background Previous studies on the effects of mycotoxins have solely focused on their biochemical profiles or products in dairy ruminants. Changes in metabolism that occur after exposure to mycotoxins, as well as biochemical changes, have not been explored. Methods We measured the biochemical and metabolic changes in dairy cows after exposure to mycotoxins using biochemical analyses and nuclear magnetic resonance. Twenty-four dairy cows were randomly assigned to three different treatment groups. Control cows received diets with 2 kg uncontaminated cottonseed. Cows in the 50% replacement group received the same diet as the control group, but with 1 kg of uncontaminated cottonseed and 1 kg of cottonseed contaminated with mycotoxins. Cows in the 100% replacement group received the same diet as the control, but with 2 kg contaminated cottonseed. Results The results showed that serum γ-glutamyl transpeptidase and total antioxidant capacities were significantly affected by cottonseed contaminated with mycotoxins. There were also significant differences in isovalerate and NH3-N levels, and significant differences in the eight plasma metabolites among the three groups. These metabolites are mainly involved in amino acid metabolism pathways. Therefore, the results suggest that amino acid metabolism pathways may be affected by mycotoxins exposure. |
| first_indexed | 2024-03-09T07:03:25Z |
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| id | doaj.art-a503fc9df1c747ec89943b7a234c789a |
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| issn | 2167-8359 |
| language | English |
| last_indexed | 2024-03-09T07:03:25Z |
| publishDate | 2020-03-01 |
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| spelling | doaj.art-a503fc9df1c747ec89943b7a234c789a2023-12-03T09:46:19ZengPeerJ Inc.PeerJ2167-83592020-03-018e874210.7717/peerj.8742The biochemical and metabolic profiles of dairy cows with mycotoxins-contaminated dietsQian Wang0Yangdong Zhang1Nan Zheng2Shengguo Zhao3Songli Li4Jiaqi Wang5Chinese Academy of Agricultural Sciences, State Key Laboratory of Animal Nutrition, Institute of Animal Science, Beijing, People’s Republic of ChinaChinese Academy of Agricultural Sciences, State Key Laboratory of Animal Nutrition, Institute of Animal Science, Beijing, People’s Republic of ChinaChinese Academy of Agricultural Sciences, State Key Laboratory of Animal Nutrition, Institute of Animal Science, Beijing, People’s Republic of ChinaChinese Academy of Agricultural Sciences, State Key Laboratory of Animal Nutrition, Institute of Animal Science, Beijing, People’s Republic of ChinaChinese Academy of Agricultural Sciences, State Key Laboratory of Animal Nutrition, Institute of Animal Science, Beijing, People’s Republic of ChinaChinese Academy of Agricultural Sciences, State Key Laboratory of Animal Nutrition, Institute of Animal Science, Beijing, People’s Republic of ChinaBackground Previous studies on the effects of mycotoxins have solely focused on their biochemical profiles or products in dairy ruminants. Changes in metabolism that occur after exposure to mycotoxins, as well as biochemical changes, have not been explored. Methods We measured the biochemical and metabolic changes in dairy cows after exposure to mycotoxins using biochemical analyses and nuclear magnetic resonance. Twenty-four dairy cows were randomly assigned to three different treatment groups. Control cows received diets with 2 kg uncontaminated cottonseed. Cows in the 50% replacement group received the same diet as the control group, but with 1 kg of uncontaminated cottonseed and 1 kg of cottonseed contaminated with mycotoxins. Cows in the 100% replacement group received the same diet as the control, but with 2 kg contaminated cottonseed. Results The results showed that serum γ-glutamyl transpeptidase and total antioxidant capacities were significantly affected by cottonseed contaminated with mycotoxins. There were also significant differences in isovalerate and NH3-N levels, and significant differences in the eight plasma metabolites among the three groups. These metabolites are mainly involved in amino acid metabolism pathways. Therefore, the results suggest that amino acid metabolism pathways may be affected by mycotoxins exposure.https://peerj.com/articles/8742.pdfBiochemicalCottonseedDairy cowMetabolomicMycotoxin |
| spellingShingle | Qian Wang Yangdong Zhang Nan Zheng Shengguo Zhao Songli Li Jiaqi Wang The biochemical and metabolic profiles of dairy cows with mycotoxins-contaminated diets PeerJ Biochemical Cottonseed Dairy cow Metabolomic Mycotoxin |
| title | The biochemical and metabolic profiles of dairy cows with mycotoxins-contaminated diets |
| title_full | The biochemical and metabolic profiles of dairy cows with mycotoxins-contaminated diets |
| title_fullStr | The biochemical and metabolic profiles of dairy cows with mycotoxins-contaminated diets |
| title_full_unstemmed | The biochemical and metabolic profiles of dairy cows with mycotoxins-contaminated diets |
| title_short | The biochemical and metabolic profiles of dairy cows with mycotoxins-contaminated diets |
| title_sort | biochemical and metabolic profiles of dairy cows with mycotoxins contaminated diets |
| topic | Biochemical Cottonseed Dairy cow Metabolomic Mycotoxin |
| url | https://peerj.com/articles/8742.pdf |
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