Donor Heart Preservation with Hydrogen Sulfide: A Systematic Review and Meta-Analysis
Preclinical studies have shown that postconditioning with hydrogen sulfide (H<sub>2</sub>S) exerts cardioprotective effects against myocardial ischemia-reperfusion injury (IRI). The aim of this study was to appraise the current evidence of the cardioprotective effects of H<sub>2<...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-05-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/22/11/5737 |
| Summary: | Preclinical studies have shown that postconditioning with hydrogen sulfide (H<sub>2</sub>S) exerts cardioprotective effects against myocardial ischemia-reperfusion injury (IRI). The aim of this study was to appraise the current evidence of the cardioprotective effects of H<sub>2</sub>S against IRI in order to explore the future implementation of H<sub>2</sub>S in clinical cardiac transplantation. The current literature on H<sub>2</sub>S postconditioning in the setting of global myocardial ischemia was systematically reviewed and analyzed, performing meta-analyses. A literature search of the electronic databases Medline, Embase and Cinahl identified 1835 studies that were subjected to our pre-defined inclusion criteria. Sixteen studies were considered eligible for inclusion. Postconditioning with H<sub>2</sub>S showed significant robust effects with regard to limiting infarct size (standardized mean difference (SMD) = −4.12, 95% CI [−5.53–−2.71], <i>p</i> < 0.00001). Furthermore, H<sub>2</sub>S postconditioning consistently resulted in a significantly lower release of cardiac injury markers, lower levels of oxidative stress and improved cardiac function. Postconditioning with slow-releasing H<sub>2</sub>S donors offers a valuable opportunity for novel therapies within cardiac preservation for transplantation. Before clinical implication, studies evaluating the long-term effects of H<sub>2</sub>S treatment and effects of H<sub>2</sub>S treatment in large animal studies are warranted. |
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| ISSN: | 1661-6596 1422-0067 |